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View article: Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology
Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology Open
Astaxanthin (ASX) is a xanthophyll carotenoid mainly derived from marine microalgae such as Haematococcus pluvialis and Chlorella zofingiensis, as well as the yeast Phaffia rhodozyma. Its chemical nature structure, rich in conjugated doubl…
View article: Role of Perinatal Stem Cell Secretome as Potential Therapy for Muscular Dystrophies
Role of Perinatal Stem Cell Secretome as Potential Therapy for Muscular Dystrophies Open
Inflammation mechanisms play a critical role in muscle homeostasis, and in Muscular Dystrophies (MDs), the myofiber damage triggers chronic inflammation which significantly controls the disease progression. Immunomodulatory strategies able…
View article: Label-free live characterization of mesenchymal stem cell spheroids by biophysical properties measurement
Label-free live characterization of mesenchymal stem cell spheroids by biophysical properties measurement Open
Three-dimensional (3D) cell culture has become a consolidated method in the stem cell field, where mesenchymal stromal stem cells (MSCs) can be used to generate in vitro spheroid aggregates called MSC-Spheroids (MSph). MSph is a floating c…
View article: Advanced seismic retrofitting with high-mass-ratio Tuned Mass Dampers
Advanced seismic retrofitting with high-mass-ratio Tuned Mass Dampers Open
Tuned Mass Dampers (TMDs) are traditionally employed in tall buildings to control displacements, typically featuring a low mass ratio. This study explores the potential of TMDs with significantly higher mass ratios for seismic retrofitting…
View article: State of the Art and New Trends from the Second International StemNet Meeting
State of the Art and New Trends from the Second International StemNet Meeting Open
The Second International StemNet (Federation of Stem Cell Research Associations) meeting took place on 18–20 October 2023 in Brescia (Italy), with the support of the University of Brescia and the Zooprophylactic Institute of Lombardy and E…
View article: Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization
Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization Open
The field of biomedical engineering highly demands technological improvements to allow the successful engraftment of biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, part…
View article: Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine
Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine Open
Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS) is not balanced by the body’s antioxidant defense system. OS can profoundly affect cellular health and function. ROS can have a profound negative impact on c…
View article: Plumbagin, a Natural Compound with Several Biological Effects and Anti-Inflammatory Properties
Plumbagin, a Natural Compound with Several Biological Effects and Anti-Inflammatory Properties Open
Phytochemicals from various medicinal plants are well known for their antioxidant properties and anti-cancer effects. Many of these bioactive compounds or natural products have demonstrated effects against inflammation, while some showed a…
View article: Non-Permissive Parvovirus B19 Infection: A Reservoir and Questionable Safety Concern in Mesenchymal Stem Cells
Non-Permissive Parvovirus B19 Infection: A Reservoir and Questionable Safety Concern in Mesenchymal Stem Cells Open
Mesenchymal stromal/stem cells (MSCs) are multipotent cells with differentiation, immunoregulatory and regenerative properties. Because of these features, they represent an attractive tool for regenerative medicine and cell-based therapy. …
View article: By-Product Extracts from Castanea sativa Counteract Hallmarks of Neuroinflammation in a Microglial Model
By-Product Extracts from Castanea sativa Counteract Hallmarks of Neuroinflammation in a Microglial Model Open
Castanea sativa is very common in Italy, and the large amount of waste material generated during chestnut processing has a high environmental impact. Several studies demonstrated that chestnut by-products are a good source of bioactive com…
View article: Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy
Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy Open
Type 1 diabetes mellitus (T1DM) is a complex metabolic disease characterized by a massive loss of insulin-producing cells due to an autoimmune reaction. Currently, daily subcutaneous administration of exogenous insulin is the only effectiv…
View article: A GLANCE AT OPTIMAL CONFIGURATIONS OF LARGE MASS TUNED MASS DAMPERS IN SOIL-STRUCTURE SYSTEMS
A GLANCE AT OPTIMAL CONFIGURATIONS OF LARGE MASS TUNED MASS DAMPERS IN SOIL-STRUCTURE SYSTEMS Open
The use of Tuned Mass Dampers featured by a Large Mass ratio (LM-TMDs) can represent an efficient solution for the seismic risk mitigation of structures, especially for seismic retrofitting of existing buildings in which a LM-TMD is concei…
View article: Perinatal Stem Cell Therapy to Treat Type 1 Diabetes Mellitus: A Never-Say-Die Story of Differentiation and Immunomodulation
Perinatal Stem Cell Therapy to Treat Type 1 Diabetes Mellitus: A Never-Say-Die Story of Differentiation and Immunomodulation Open
Human term placenta and other postpartum-derived biological tissues are promising sources of perinatal cells with unique stem cell properties. Among the massive current research on stem cells, one medical focus on easily available stem cel…
View article: Celector®: An Innovative Technology for Quality Control of Living Cells
Celector®: An Innovative Technology for Quality Control of Living Cells Open
Among the in vitro and ex vivo models used to study human cancer biology, cancer cell lines are widely utilized. The standardization of a correct tumor model including the stage of in vitro testing would allow for the development of new hi…
View article: Host–Pathogen Interactions: Organotypic Cultures to Unravel the Mysteries of the Primordial Hostility among Organisms
Host–Pathogen Interactions: Organotypic Cultures to Unravel the Mysteries of the Primordial Hostility among Organisms Open
The interaction of humans with microorganisms represents a subtle balance between harm and good [...]
View article: A Tailored Lipid Supplement Restored Membrane Fatty Acid Composition and Ameliorates In Vitro Biological Features of Human Amniotic Epithelial Cells
A Tailored Lipid Supplement Restored Membrane Fatty Acid Composition and Ameliorates In Vitro Biological Features of Human Amniotic Epithelial Cells Open
Cell culture conditions influence several biological and biochemical features of stem cells (SCs), including the membrane lipid profile, thus limiting the use of SCs for cell therapy approaches. The present study aims to investigate whethe…
View article: Effective Label-Free Sorting of Multipotent Mesenchymal Stem Cells from Clinical Bone Marrow Samples
Effective Label-Free Sorting of Multipotent Mesenchymal Stem Cells from Clinical Bone Marrow Samples Open
Mesenchymal stem cells (MSC) make up less than 1% of the bone marrow (BM). Several methods are used for their isolation such as gradient separation or centrifugation, but these methodologies are not direct and, thus, plastic adherence outg…
View article: Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype
Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype Open
Skeletal muscle regeneration is a complex process involving crosstalk between immune cells and myogenic precursor cells, i.e., satellite cells. In this scenario, macrophage recruitment in damaged muscles is a mandatory step for tissue repa…
View article: Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?
Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research? Open
In order to prevent new pathogen outbreaks and avoid possible new global health threats, it is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents and test new vaccines using the best methods. In the la…
View article: Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome
Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome Open
Antibiotic resistance is creating enormous attention on the development of new antibiotic-free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are the most promising candidates in current clinical trials an…
View article: Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin
Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin Open
Bioinspired organ-level in vitro platforms that recapitulate human organ physiology and organ-specific responses have emerged as effective technologies for infectious disease research, drug discovery, and personalized medicine. A major cha…
View article: The Potential of Honeybee Products for Biomaterial Applications
The Potential of Honeybee Products for Biomaterial Applications Open
The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; mo…
View article: Antioxidant and Anti‐Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration
Antioxidant and Anti‐Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration Open
Spent coffee grounds (SCGs), waste products of coffee beverage production, are rich in organic compounds such as phenols. Different studies have demonstrated phenol beneficial effects in counteracting neurodegenerative diseases. These dise…
View article: Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System
Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System Open
The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of this work was to st…
View article: Leaves and Spiny Burs of Castanea Sativa from an Experimental Chestnut Grove: Metabolomic Analysis and Anti-Neuroinflammatory Activity
Leaves and Spiny Burs of Castanea Sativa from an Experimental Chestnut Grove: Metabolomic Analysis and Anti-Neuroinflammatory Activity Open
Castanea sativa cultivation has been present in Mediterranean regions since ancient times. In order to promote a circular economy, it is of great importance to valorize chestnut groves’ by-products. In this study, leaves and spiny burs fro…
View article: Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering
Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering Open
Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or ce…
View article: Combined Treatment with Three Natural Antioxidants Enhances Neuroprotection in a SH-SY5Y 3D Culture Model
Combined Treatment with Three Natural Antioxidants Enhances Neuroprotection in a SH-SY5Y 3D Culture Model Open
Currently, the majority of cell-based studies on neurodegeneration are carried out on two-dimensional cultured cells that do not represent the cells residing in the complex microenvironment of the brain. Recent evidence has suggested that …