Markus R. Meyer
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View article: Synthetic hydroxyapatite: a perfect substitute for dental enamel in biofilm formation studies
Synthetic hydroxyapatite: a perfect substitute for dental enamel in biofilm formation studies Open
View article: Optimizing multiomics sample preparation: comparative evaluation of extraction protocols for HepG2 cells
Optimizing multiomics sample preparation: comparative evaluation of extraction protocols for HepG2 cells Open
Multiomics approaches enable a comprehensive characterization of complex biological systems by simultaneously investigating multiple molecular layers. Generating multiple omics datasets from a single sample is crucial to minimize biologica…
View article: TRPV6 channel function is involved in endometrial epithelial cell Ca2+ signaling and female mouse fecundity
TRPV6 channel function is involved in endometrial epithelial cell Ca2+ signaling and female mouse fecundity Open
The Ca 2+ -selective transient receptor potential vanilloid 6 (TRPV6) channel plays a fundamental role in the female and male murine reproductive system. We have previously shown that TRPV6 is essential for male fertility, and necessary fo…
View article: In vitro toxicokinetics and metabolic profiling of methoxycathinones and methylthiocathinones using human liver systems and hyphenated mass spectrometry
In vitro toxicokinetics and metabolic profiling of methoxycathinones and methylthiocathinones using human liver systems and hyphenated mass spectrometry Open
Ring-substituted synthetic cathinones represent a major subgroup within new psychoactive substances. This study investigated the in vitro toxicokinetics of the three 4-methoxy-substituted representatives 4MeO-NE-BP (4’-methoxy- N -ethylbut…
View article: Comprehensive Conduction System Pacing as Antiarrhythmic Strategy in Atrial Fibrillation
Comprehensive Conduction System Pacing as Antiarrhythmic Strategy in Atrial Fibrillation Open
The current era of pacemaker technology allows for the treatment of cardiac conditions beyond electrical impulse formation or conduction alone. In this report we highlight that comprehensive atrial and ventricular conduction system pacing …
View article: The GAPS programme at TNG LXVIII. Characterization of the outer substellar companion around HD 72659 with a multitechnique approach
The GAPS programme at TNG LXVIII. Characterization of the outer substellar companion around HD 72659 with a multitechnique approach Open
Before discovering the first exoplanets, the radial velocity (RV) method had been used for decades to discover binary stars. Despite significant advancements in this technique, it is limited by the intrinsic mass-inclination degeneracy tha…
View article: A Comparative Study Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography to Investigate the In Vitro and In Vivo Metabolism of Five Selenium-Containing Cathinone Derivatives
A Comparative Study Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography to Investigate the In Vitro and In Vivo Metabolism of Five Selenium-Containing Cathinone Derivatives Open
Background/Objectives: The emergence of cathinone-based psychostimulants necessitates ongoing research and analysis of the characteristics and properties of novel derivatives. The metabolic fate of five novel cathinone-derived substances (…
View article: Polyclonal antibodies towards abrin and ricin—design and potential application for mass spectrometry-based analysis of human biosamples
Polyclonal antibodies towards abrin and ricin—design and potential application for mass spectrometry-based analysis of human biosamples Open
View article: Medication adherence in patients with acutely decompensated heart failure: A cross‐sectional study in the emergency department (<scp>ADHF</scp>‐<scp>ED</scp>)
Medication adherence in patients with acutely decompensated heart failure: A cross‐sectional study in the emergency department (<span>ADHF</span>‐<span>ED</span>) Open
Aims Non‐adherence to guideline‐directed medical therapy may worsen outcomes in chronic heart failure (CHF). Objectively assessed adherence in patients presenting with acutely decompensated heart failure (ADHF) remains largely unexplored. …
View article: Laminar Flow Alters EV Composition in HUVECs: A Study of Culture Medium Optimization and Molecular Profiling of Vesicle Cargo
Laminar Flow Alters EV Composition in HUVECs: A Study of Culture Medium Optimization and Molecular Profiling of Vesicle Cargo Open
Endothelial cells (ECs) experience shear stress associated with blood flow. Such shear stress regulates endothelial function by altering cell physiology. Since most cell culture protocols and media compositions are designed for static cult…
View article: Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing
Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing Open
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP w…
View article: The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities
The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities Open
The proton therapy facility in Dresden, Germany, has one treatment room equipped with a rotating gantry where patients are treated and an experimental room equipped with two horizontal beamlines for translational research. The present work…
View article: Editorial: Current trends in targeted and non-targeted metabolomics in analytical toxicology
Editorial: Current trends in targeted and non-targeted metabolomics in analytical toxicology Open
View article: Overcoming limitations in exhaled breath aerosol analysis – Untargeted breathomics for the identification of endogenous breath biomarkers using LC-HRMS/MS
Overcoming limitations in exhaled breath aerosol analysis – Untargeted breathomics for the identification of endogenous breath biomarkers using LC-HRMS/MS Open
This study represents a step forward in overcoming the current limitation of EB analysis, the lack of standardization in sampling procedure. Nevertheless, further investigation including correlation studies and more diverse populations wil…
View article: Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies
Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies Open
View article: The SPHERE infrared survey for exoplanets (SHINE)
The SPHERE infrared survey for exoplanets (SHINE) Open
Context. Over the past decade, large surveys with state-of-the-art planet-finder instruments such as Spectro-Polarimetric High-contrast Exoplanet REsearch on board Very Large Telescope (SPHERE@VLT), coupled with coronagraphic devices and e…
View article: The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production
The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production Open
Background The syncytiotrophoblast (STB) layer of the placenta is formed by cell fusion of cytotrophoblasts, acts as a feto-maternal barrier, is required for the production of pregnancy hormones such as chorionic gonadotropin, estradiol an…
View article: Toxicokinetics and analytical toxicology of the phenmetrazine-derived new psychoactive substance 3,4-methylenedioxyphenmetrazine studied by means of in vitro systems
Toxicokinetics and analytical toxicology of the phenmetrazine-derived new psychoactive substance 3,4-methylenedioxyphenmetrazine studied by means of in vitro systems Open
Compounds derived from known drugs are usually brought on the new psychoactive substance (NPS) market without any previous toxicological risk assessment. The European Union Drugs Agency issued an EU early notification for 3,4-methylenediox…
View article: The SPHERE infrared survey for exoplanets (SHINE). V. Complete observations, data reduction and analysis, detection performances, and final results
The SPHERE infrared survey for exoplanets (SHINE). V. Complete observations, data reduction and analysis, detection performances, and final results Open
During the past decade, state-of-the-art planet-finder instruments like SPHERE@VLT, coupling coronagraphic devices and extreme adaptive optics systems, unveiled, thanks to large surveys, around 20 planetary mass companions at semi-major ax…
View article: Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MS<sup>n</sup> System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma
Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MS<sup>n</sup> System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma Open
Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of acute intoxications and to monitor their progression and efficacy of detoxificat…
View article: Commissioning of the MIRAC-5 Mid-infrared Instrument on the MMT
Commissioning of the MIRAC-5 Mid-infrared Instrument on the MMT Open
We present results from commissioning observations of the mid-IR instrument, MIRAC-5, on the 6.5 m MMT telescope. MIRAC-5 is a novel ground-based instrument that utilizes a state-of-the-art GeoSnap (2–13 µ m) HgCdTe detector with adaptive …
View article: Commissioning of the MIRAC-5 Mid-Infrared Instrument on the MMT
Commissioning of the MIRAC-5 Mid-Infrared Instrument on the MMT Open
We present results from commissioning observations of the mid-IR instrument,\nMIRAC-5, on the 6.5-m MMT telescope. MIRAC-5 is a novel ground-based instrument\nthat utilizes a state-of-the-art GeoSnap (2 - 13 microns) HgCdTe detector with\n…
View article: Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening
Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening Open
Wastewater (WW)‐based epidemiology (WBE) is a powerful tool for screening and surveillance of drugs (of abuse) or new psychoactive substances (NPSs) in larger population. Since the drug market changes frequently, it is crucial for WBE to d…
View article: Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs Open
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker, which can potentially lead to al…
View article: Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration
Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration Open
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not u…
View article: Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial Open
Background and Aims Patients with heart failure with preserved ejection fraction (HFpEF) tend to have low resting and exercise heart rates. Phosphodiesterase‐3 (PDE‐3) inhibitors improve heart rates, haemodynamics and symptoms in patients …
View article: Large Interferometer For Exoplanets (LIFE). XIV. Finding terrestrial protoplanets in the galactic neighborhood
Large Interferometer For Exoplanets (LIFE). XIV. Finding terrestrial protoplanets in the galactic neighborhood Open
The increased brightness temperature of young rocky protoplanets during their magma ocean epoch makes them potentially amenable to atmospheric characterization to distances from the solar system far greater than thermally equilibrated terr…
View article: Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs
Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs Open
The number of fatal cases involving synthetic cannabinoids (SCs) is increasing. However, interpretation of postmortem (PM) toxicological findings is challenging, due to unknown PM intervals and possible redistribution processes or instabil…
View article: Direct imaging and dynamical mass of a benchmark T-type brown dwarf companion to HD 167665
Direct imaging and dynamical mass of a benchmark T-type brown dwarf companion to HD 167665 Open
Context . A low-mass companion potentially in the brown dwarf mass regime was discovered on a ~12 yr orbit (~5.5 au) around HD 167665 using radial velocity (RV) monitoring. Joint RV–astrometry analyses confirmed that HD 167665B is a brown …
View article: Author Correction: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice
Author Correction: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice Open