Mohsen Sadatsafavi
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View article: Transportability of Prognostic Markers: Rethinking Common Practices through a Sufficient-Component-Cause Perspective
Transportability of Prognostic Markers: Rethinking Common Practices through a Sufficient-Component-Cause Perspective Open
Transportability, the ability to maintain performance across populations, is a desirable property of markers of clinical outcomes. However, empirical findings indicate that markers often exhibit varying performances across populations. For…
View article: Temporal trends and regional variations in the burden of chronic obstructive pulmonary disease
Temporal trends and regional variations in the burden of chronic obstructive pulmonary disease Open
View article: Evaluating treatment benefit predictors using observational data: contending with identification and confounding bias
Evaluating treatment benefit predictors using observational data: contending with identification and confounding bias Open
A treatment benefit predictor (TBP) is a function that maps patient characteristics to a putative treatment benefit for that patient. Such predictors support optimizing individualized treatment decisions, which are central to precision med…
View article: Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i>
Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i> Open
International audience
View article: Risk prediction for lung cancer screening: a systematic review and meta-regression
Risk prediction for lung cancer screening: a systematic review and meta-regression Open
Background Lung cancer (LC) is the leading cause of cancer mortality, often diagnosed at advanced stages. Screening reduces mortality in high-risk individuals, but its efficiency can improve with pre- and post-screening risk stratification…
View article: Comparison of Quadruple Therapy Sequencing Strategies for Heart Failure With Reduced Ejection Fraction
Comparison of Quadruple Therapy Sequencing Strategies for Heart Failure With Reduced Ejection Fraction Open
Background Guidelines unanimously recommend quadruple therapy for patients with heart failure with reduced ejection fraction (HFrEF), yet direct comparative evidence is lacking to recommend a specific order of initiating and titrating thes…
View article: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach
Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach Open
T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum th…
View article: Optimizing Communication Strategies for COPD Management: Effectiveness of Educational Video and Pamphlet Interventions
Optimizing Communication Strategies for COPD Management: Effectiveness of Educational Video and Pamphlet Interventions Open
Objectives Risk prediction models are increasingly used at point of care to support personalized treatment decisions. This study created and evaluated two Information, Education, and Communication (IEC) resources to improve public understa…
View article: Trends and Regional Differences in the Use of Maintenance Inhaled Medications in COPD: A Population-Based Study
Trends and Regional Differences in the Use of Maintenance Inhaled Medications in COPD: A Population-Based Study Open
View article: High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome
High‐Dimensional Disease Risk Score for Dealing With Residual Confounding Bias in Estimating Treatment Effects With a Survival Outcome Open
Purpose Health administrative databases often contain no information on some important confounders, leading to residual confounding in the effect estimate. We aimed to explore the performance of high‐dimensional disease risk score (hdDRS) …
View article: Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)
Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR) Open
OCS, whether prescribed intermittently or long term, affect BEC distribution potentially leading to heightened risk of phenotype misclassification and influencing subsequent treatment decisions. FeNO appears to be less susceptible to OCS-i…
View article: Mapping EQ-5D-5L Score From SGRQ in Patients with Asthma and/or COPD in NOVELTY
Mapping EQ-5D-5L Score From SGRQ in Patients with Asthma and/or COPD in NOVELTY Open
Including additional covariates and SGRQ domains resulted in similar model performance to Starkie et al, suggesting their covariates are adequate for mapping in asthma and/or COPD. NOVELTY coefficients broaden the population with chronic a…
View article: Prediction Pathway for Severe Asthma Exacerbations
Prediction Pathway for Severe Asthma Exacerbations Open
View article: Guideline-concordant inhaled medication use in COPD: a systematic review of definitions used in administrative health data
Guideline-concordant inhaled medication use in COPD: a systematic review of definitions used in administrative health data Open
Background Assessments of guideline-discordant use of maintenance inhaled therapies for COPD in administrative health data are common but restricted by lack of patient characteristics. We systematically reviewed definitions of guideline-co…
View article: Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data
Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data Open
Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.
View article: Healthcare utilization trends in adults with asthma or COPD during the first year of COVID-19 pandemic in comparison to pre-pandemic: A population-based study
Healthcare utilization trends in adults with asthma or COPD during the first year of COVID-19 pandemic in comparison to pre-pandemic: A population-based study Open
Objectives To assess how changes in outpatient services during the first year of the COVID-19 pandemic were related to acute healthcare use (emergency department or hospitalizations) for individuals with asthma or chronic obstructive pulmo…
View article: Should all patients with COPD be treated with inhaled triple therapy?
Should all patients with COPD be treated with inhaled triple therapy? Open
Triple therapy should be initiated earlier in the course of COPD https://bit.ly/3Nh9W6j.
View article: Expected Value of Sample Information Calculations for Risk Prediction Model Validation
Expected Value of Sample Information Calculations for Risk Prediction Model Validation Open
Background The purpose of external validation of a risk prediction model is to evaluate its performance before recommending it for use in a new population. Sample size calculations for such validation studies are currently based on classic…
View article: Recent Advances, Applications and Open Challenges in Machine Learning for Health: Reflections from Research Roundtables at ML4H 2024 Symposium
Recent Advances, Applications and Open Challenges in Machine Learning for Health: Reflections from Research Roundtables at ML4H 2024 Symposium Open
The fourth Machine Learning for Health (ML4H) symposium was held in person on December 15th and 16th, 2024, in the traditional, ancestral, and unceded territories of the Musqueam, Squamish, and Tsleil-Waututh Nations in Vancouver, British …
View article: A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- Part 2: time-to-event outcomes
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- Part 2: time-to-event outcomes Open
Background: When developing a clinical prediction model using time-to-event data, previous research focuses on the sample size to minimise overfitting and precisely estimate the overall risk. However, instability of individual-level risk e…
View article: Regional Variations in Burden of Chronic Obstructive Pulmonary Disease
Regional Variations in Burden of Chronic Obstructive Pulmonary Disease Open
Background Chronic Obstructive Pulmonary Disease (COPD) imposes a significant burden on individuals and communities. While differences in such burden are often studied across countries and healthcare systems, differences within jurisdictio…
View article: Development&nbsp; and Validation of PRECISE-X, a Risk Prediction Model for the First Severe Exacerbation in Patients with Chronic Obstructive Pulmonary Disease
Development and Validation of PRECISE-X, a Risk Prediction Model for the First Severe Exacerbation in Patients with Chronic Obstructive Pulmonary Disease Open
View article: Impact analysis of infant antibiotic exposure on the burden of asthma: a simulation modeling study
Impact analysis of infant antibiotic exposure on the burden of asthma: a simulation modeling study Open
Background Infant antibiotic use is associated with increased risk of asthma. We examined the population impact of antibiotic exposure in the first year of life on the burden of pediatric asthma in British Columbia, Canada, using simulatio…
View article: mcmapper: Mapping First Moment and C-Statistic to the Parameters of Distributions for Risk
mcmapper: Mapping First Moment and C-Statistic to the Parameters of Distributions for Risk Open
View article: 20-year trends in excess costs of COPD
20-year trends in excess costs of COPD Open
Background Several major risk factors for COPD, such as population ageing, smoking rates and air pollution levels, are rapidly changing, causing inevitable changes in the population burden of COPD. We determined the excess direct costs of …
View article: Pharmacotherapy sequencing strategies for patients with heart failure with reduced ejection fraction: a cost–utility analysis
Pharmacotherapy sequencing strategies for patients with heart failure with reduced ejection fraction: a cost–utility analysis Open
BACKGROUND: Standard pharmacotherapy for patients with heart failure with reduced ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin system inhibitor, a β-blocker, a mineralocorticoid receptor antagonist, and …
View article: Expected value of sample information calculations for risk prediction model development
Expected value of sample information calculations for risk prediction model development Open
Risk prediction models are often advertised as deterministic functions that map covariates to predicted risks. However, they are typically trained using finite samples, and as such, their predictions are inherently uncertain. This uncertai…
View article: Identification of distributions for risks based on the first moment and c-statistic
Identification of distributions for risks based on the first moment and c-statistic Open
We show that for any family of distributions with support on [0,1] with strictly monotonic cumulative distribution function that has no jumps and is quantile-identifiable (i.e., any two distinct quantiles identify the distribution), knowin…
View article: Stakeholder-informed positivity thresholds for disease markers and risk scores: a methodological framework and an application in obstructive lung disease
Stakeholder-informed positivity thresholds for disease markers and risk scores: a methodological framework and an application in obstructive lung disease Open
The proposed methodology can be applied to many contexts where the objective is to devise positivity thresholds that need to incorporate stakeholder preferences. Applying this framework to chronic obstructive pulmonary disease pharmacother…
View article: Socioeconomic burden of cystic fibrosis in Canada
Socioeconomic burden of cystic fibrosis in Canada Open
Background Cost of illness studies are important tools to summarise the burden of disease for individuals, the healthcare system and society. The lack of standardised methods for reporting costs for cystic fibrosis (CF) makes it difficult …