Nitin Gupta
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View article: Culture-negative bacteria: a blind spot in bacterial pathogen prioritization
Culture-negative bacteria: a blind spot in bacterial pathogen prioritization Open
Culture-negative bacteria (CNB), including Bartonella spp., Coxiella burnetii, Rickettsia spp., Orientia tsutsugamushi, and Leptospira spp., are frequent yet underrecognized causes of febrile illness in low- and middle-income countries (LM…
View article: Temporal Dynamics of the Immune Response in Severe Cases of Human Kyasanur Forest Disease Virus (KFDV) Infection
Temporal Dynamics of the Immune Response in Severe Cases of Human Kyasanur Forest Disease Virus (KFDV) Infection Open
The immunopathogenesis of KFDV is not well understood. The study's primary objective was to investigate the magnitude and dynamics of cytokine and cellular immune responses during the acute and convalescent phases of KFDV infection in huma…
View article: Role of biomarkers in predicting mortality in patients with flaviviral disease endemic to South India: a retrospective observational study
Role of biomarkers in predicting mortality in patients with flaviviral disease endemic to South India: a retrospective observational study Open
Background Flaviviral infections such as dengue and Kyasanur Forest Disease (KFD) are endemic causes of acute febrile illness in South India, with some cases progressing to severe disease and death. Methods We conducted a retrospective obs…
View article: <i>Coxiella burnetii</i> and <i>Bartonella</i> species serology of febrile patients with an established infectious or inflammatory diagnosis in Sudan, Nepal, and Cambodia
<i>Coxiella burnetii</i> and <i>Bartonella</i> species serology of febrile patients with an established infectious or inflammatory diagnosis in Sudan, Nepal, and Cambodia Open
Coxiella burnetii and Bartonella species cause febrile illness and infective endocarditis in low- and middle-income countries (LMICs). This study investigated whether seropositivity to C. burnetii or Bartonella could be detected among pati…
View article: Tunnel sign on magnetic resonance imaging in neuromelioidosis: A systematic literature review
Tunnel sign on magnetic resonance imaging in neuromelioidosis: A systematic literature review Open
Background: Neuromelioidosis can present with abscesses, meningitis, or encephalomyelitis, but can be missed on blood culture. Linear enhancement of the corticospinal tract (white matter motor pathway) on magnetic resonance imaging (MRI) i…
View article: Study of association between valproic acid levels, biotinidase activity and hair loss in Indian population: A cross-sectional comparative study
Study of association between valproic acid levels, biotinidase activity and hair loss in Indian population: A cross-sectional comparative study Open
Background: Valproic acid (VPA) is the medication prescribed for the treatment of bipolar disorder, epilepsy, and migraine. It is reported that the VPA treatment leads to biotin deficiency due to the low serum biotinidase activity. Alopeci…
View article: Graft Arteritis Due to <i>Candida</i> Spp. After Kidney Transplant: A Systematic Review of Individual Cases
Graft Arteritis Due to <i>Candida</i> Spp. After Kidney Transplant: A Systematic Review of Individual Cases Open
Background Graft arteritis due to Candida species (GAC) is a rare but life-threatening complication in kidney transplant recipients. This systematic review examines its clinical profile and outcomes. Methods A PRISMA-compliant systematic r…
View article: BimABm positivity in melioidosis and its impact on clinical profile, and outcomes: a retrospective cohort study
BimABm positivity in melioidosis and its impact on clinical profile, and outcomes: a retrospective cohort study Open
Although uncommon, the BimABm allele is strongly associated with neurological melioidosis in southern India.
View article: Candida graft arteritis after kidney transplantation: two cases and literature review
Candida graft arteritis after kidney transplantation: two cases and literature review Open
Background: Candida arteritis of a kidney allograft represents a severe yet rare complication in transplant recipients. Its nonspecific presentation and diagnostic difficulties necessitate a high level of clinical suspicion and a multidisc…
View article: Clinical scoring system to differentiate melioidosis from other documented causes of community-acquired bacterial pneumonia: a retrospective cohort study
Clinical scoring system to differentiate melioidosis from other documented causes of community-acquired bacterial pneumonia: a retrospective cohort study Open
Background Melioidosis, caused by Burkholderia pseudomallei , is an underdiagnosed cause of community-acquired pneumonia (CAP) in India. Due to overlapping features with other bacterial pneumonias and limited access to culture facilities, …
View article: Role of cycle threshold values in predicting poor outcomes in patients with Kyasanur Forest disease: a retrospective cohort study
Role of cycle threshold values in predicting poor outcomes in patients with Kyasanur Forest disease: a retrospective cohort study Open
Lower Ct values are independently associated with increased mortality in KFD and may serve as a pragmatic tool for early risk stratification, especially in resource-limited settings.
View article: Neurological involvement in two phases of Kyasanur Forest Disease
Neurological involvement in two phases of Kyasanur Forest Disease Open
Kyasanur Forest Disease (KFD) is a tick-borne viral illness endemic to Southern India, often categorized as viral haemorrhagic fever, though its biphasic neurological involvement is less frequently discussed. We present the case of an elde…
View article: Clinical profile and outcomes of pulmonary nocardiosis in India: a systematic review of individual cases
Clinical profile and outcomes of pulmonary nocardiosis in India: a systematic review of individual cases Open
Pulmonary nocardiosis presents diagnostic and therapeutic challenges in India, with high resistance rates and significant mortality. Improved diagnostic methods and region-specific treatment strategies are essential.
View article: Prevalence, Risk Factors, and Clinical Outcomes of Hypervirulent Klebsiella pneumoniae Strains among Klebsiella pneumoniae Infections: A Systematic Review and Meta-analysis
Prevalence, Risk Factors, and Clinical Outcomes of Hypervirulent Klebsiella pneumoniae Strains among Klebsiella pneumoniae Infections: A Systematic Review and Meta-analysis Open
Nagendra D, Chaudhuri S, Gupta N, Shanbhag V, Eshwara VK, Rao S, et al. Prevalence, Risk Factors, and Clinical Outcomes of Hypervirulent Klebsiella pneumoniae Strains among Klebsiella pneumoniae Infections: A Systematic Review and Meta-ana…
View article: Severe bone marrow aplasia following azathioprine therapy in patients with NUDT15 deficiency: A case series
Severe bone marrow aplasia following azathioprine therapy in patients with NUDT15 deficiency: A case series Open
Azathioprine is widely used in various autoimmune disorders, hematological malignancies, inflammatory bowel disease, skin disorders, and in post renal transplants as an immunosuppressant. Myelosuppression is a well-known adverse drug react…
View article: FIB-4 score is correlated with liver fibrosis but not with liver steatosis : A Cross-Sectional Study in T2DM patients
FIB-4 score is correlated with liver fibrosis but not with liver steatosis : A Cross-Sectional Study in T2DM patients Open
Aim: The present study was conducted to evaluate the corelation between Fibrosis-4 score (FIB-4) in cases of Liver fibrosis as well as Liver steatosis in comparison to other liver fibrosis assessment scores. Methodology: Cross-sectional st…
View article: Effect of intraoperative fluid volume on postoperative pulmonary complications in thoracic surgeries: A systematic review and meta-analysis
Effect of intraoperative fluid volume on postoperative pulmonary complications in thoracic surgeries: A systematic review and meta-analysis Open
Background and Aims: There is a lack of clear recommendations on fluid strategies in patients undergoing thoracic surgeries. The primary objective of this study was to compare the amount of intraoperative intravenous fluid (IVF) infused be…
View article: Ralstonia pickettii bacteremia: A retrospective review of records
Ralstonia pickettii bacteremia: A retrospective review of records Open
We report this to highlight the possibility of infection with this rare pathogen and to increase awareness of the importance of appropriate infection control measures.
View article: Bartonella quintana Infection in Canada: A Retrospective Laboratory Study and Systematic Review of the Literature
Bartonella quintana Infection in Canada: A Retrospective Laboratory Study and Systematic Review of the Literature Open
Background:Bartonella quintana is a body-louse-borne bacterium. Canadian B. quintana disease has been reported primarily in populations experiencing homelessness and in Indigenous communities with limited access to water. We sought to unde…
View article: The Internet of Bio-Nano Things with Insulin-Glucose, Security and Research Challenges: A Survey
The Internet of Bio-Nano Things with Insulin-Glucose, Security and Research Challenges: A Survey Open
The Internet of Bio-Nano Things (IoBNT) is collaborative cell biology and nanodevice technology interacting through Molecular Communication (MC). The IoBNT can be accomplished by using the Information and Communication Theory (ICT) study o…
View article: Abscesses due to Melioidosis: A case-based review
Abscesses due to Melioidosis: A case-based review Open
Melioidosis is caused by percutaneous inoculation or inhalation of Burkholderia pseudomallei, predominantly among individuals with risk factors (diabetes mellitus, immunosuppression, etc.) from endemic areas of South Asia, Southeast Asia a…