Rudi Steffensen
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View article: Leukocyte Subset Distributions during the Midluteal Phase: Differences between Women with Recurrent Pregnancy Loss after IVF/ICSI and Fertile Controls
Leukocyte Subset Distributions during the Midluteal Phase: Differences between Women with Recurrent Pregnancy Loss after IVF/ICSI and Fertile Controls Open
View article: P-428 Immunological Profiles in Recurrent Pregnancy Loss: A Comparative Study of Immune Cell Subsets and Biomarkers in RPL Patients and Fertile Controls
P-428 Immunological Profiles in Recurrent Pregnancy Loss: A Comparative Study of Immune Cell Subsets and Biomarkers in RPL Patients and Fertile Controls Open
Study question How does leukocyte subset distribution in peripheral blood during the window of implantation (WOI) differ between women with recurrent pregnancy loss (RPL) and fertile women? Summary answer The distribution of leukocyte subs…
View article: Determination of <scp><i>CD177</i></scp> (human neutrophil antigen 2) polymorphisms using nanopore sequencing
Determination of <span><i>CD177</i></span> (human neutrophil antigen 2) polymorphisms using nanopore sequencing Open
Background and Objectives Human neutrophil antigen 2 (HNA‐2), encoded by the CD177 gene, is considered one of the most important neutrophil antigens in human medicine, but molecular testing of CD177 is complicated and therefore not a stand…
View article: Long-term outcomes of LT4/LT3 combination treatment for persistent hypothyroid symptoms
Long-term outcomes of LT4/LT3 combination treatment for persistent hypothyroid symptoms Open
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the …
View article: Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study
Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study Open
This study substantiates the north-south gradient hypothesis, highlighting that new-onset RA patients in Denmark tend to experience an older age of onset and more severe disease activity than their Turkish counterparts. Variations in risk-…
View article: Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial
Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial Open
Recurrent pregnancy loss (RPL), defined as two or more pregnancy losses before the 24th week of gestation, affects 1%–3% of women worldwide. Approximately, 40% of RPL cases are secondary RPL (sRPL), where women have given birth before faci…
View article: Pitfalls When Determining HNA-1 Genotypes and Finding Novel Alleles
Pitfalls When Determining HNA-1 Genotypes and Finding Novel Alleles Open
Genetic variation in the FCGR3B gene is responsible for different variants of human neutrophil antigen 1 (HNA-1). Laboratory techniques currently utilized for routine HNA-1 genotyping, predominantly PCR-sequence-specific primer (PCR-SSP) a…
View article: High resolution <scp>HLA</scp> genotyping with third generation sequencing technology—A multicentre study
High resolution <span>HLA</span> genotyping with third generation sequencing technology—A multicentre study Open
Molecular HLA typing techniques are currently undergoing a rapid evolution. While real‐time PCR is established as the standard method in tissue typing laboratories regarding allocation of solid organs, next generation sequencing (NGS) for …
View article: Genetic polymorphisms in <i>IL‐2</i>, <i>IL‐10</i> and <i>FOXP3</i> are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort
Genetic polymorphisms in <i>IL‐2</i>, <i>IL‐10</i> and <i>FOXP3</i> are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort Open
Autoimmune neutropenia (AIN) in early childhood is characterized by chronic neutropenia and positivity for human neutrophil antibodies (HNA), resulting in the excessive destruction of neutrophils. The association between regulatory T cells…
View article: CD21 deficiency in 2 siblings and frequency of the associated mutation in the Danish population
CD21 deficiency in 2 siblings and frequency of the associated mutation in the Danish population Open
The clinical presentation of CD21 deficiency in 2 siblings caused by a novel mutation in the CD21 gene is reported, and the frequency of this mutation in the Danish population is explored. Successful treatment with IgG replacement in both …
View article: High‐resolution <scp>HLA</scp> genotyping identifies risk alleles in both class I and <scp>II</scp> for primary autoimmune neutropenia in early childhood in a Danish cohort
High‐resolution <span>HLA</span> genotyping identifies risk alleles in both class I and <span>II</span> for primary autoimmune neutropenia in early childhood in a Danish cohort Open
HLA studies in patients with autoimmune neutropenia (AIN) have shown very consistent results for the association with HLA class II alleles at low resolution. This study aimed to examine the association of both HLA class I and class II at h…
View article: Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss
Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss Open
The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-le…
View article: Comparison of real-time quantitative PCR and two digital PCR platforms to detect copy number variation in FCGR3B
Comparison of real-time quantitative PCR and two digital PCR platforms to detect copy number variation in FCGR3B Open
The importance of structural genetic variants, such as copy number variations (CNVs), in modulating human disease is being increasingly recognized. Several clinical conditions require investigation of human neutrophil antigen (HNA-1), whic…
View article: Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis
Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis Open
Background The DNA-binding peptide LL37 is a suspected autoantigen in psoriasis. It can be found in neutrophil extracellular traps (NETs) which have been suggested to play a role in the pathogenesis of the disease. Citrullination, the conv…
View article: HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood
HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood Open
Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte antigens (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1…
View article: Campylobacter concisus from chronic inflammatory bowel diseases stimulates IL-8 production in HT-29 cells
Campylobacter concisus from chronic inflammatory bowel diseases stimulates IL-8 production in HT-29 cells Open
The emerging pathogen Campylobacter concisus has been isolated from patients with gastrointestinal diseases; however, it is also present in the gut of healthy individuals. The aim of this study was to compare IL-8 production in HT-29 cells…
View article: Genetic variations in low‐to‐medium‐affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort
Genetic variations in low‐to‐medium‐affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort Open
Autoimmune neutropenia (AIN) in early childhood is caused by autoantibodies directed against antigens on the neutrophil membrane and is a frequent cause of neutropenia in children. Association of AIN with Fcγ receptor (FCGR) 3B variants is…
View article: A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss
A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss Open
Introduction It is documented that a series of autoantibodies can be detected with increased frequency in women with recurrent pregnancy loss (RPL) and they may impact the pregnancy prognosis negatively. It is unknown whether the autoantib…
View article: Maternal carriage of H-Y restricting HLA class II alleles is a negative prognostic factor for women with recurrent pregnancy loss after birth of a boy
Maternal carriage of H-Y restricting HLA class II alleles is a negative prognostic factor for women with recurrent pregnancy loss after birth of a boy Open
Immune system aberrations are suggested to be an important factor in the pathophysiology of unexplained secondary recurrent pregnancy loss (sRPL). The objective was to investigate if the sex ratio of the firstborn child in sRPL patients di…
View article: Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a protocol for a randomised, double-blind, placebo-controlled trial
Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a protocol for a randomised, double-blind, placebo-controlled trial Open
Introduction Recurrent pregnancy loss (RPL), defined as two or more consecutive pregnancy losses in the first trimester, affects around 5% of fertile women. The underlying causes remain unknown in up to 60% of patients; however, most studi…
View article: <scp>ABO</scp>, secretor, and Lewis carbohydrate histo‐blood groups are associated with autoimmune neutropenia of early childhood in Danish patients
<span>ABO</span>, secretor, and Lewis carbohydrate histo‐blood groups are associated with autoimmune neutropenia of early childhood in Danish patients Open
Background Autoimmune neutropenia of early childhood (AIN) is caused by autoantibodies directed against antigens on the neutrophil membrane. The ABO, secretor, and Lewis histo‐blood group systems control the expression of carbohydrate anti…
View article: Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis
Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis Open
STUDY QUESTION Are low or high plasma mannose-binding lectin (p-MBL) levels associated with recurrent pregnancy loss (RPL) and the reproductive and perinatal outcomes before and after RPL? SUMMARY ANSWER The prevalence of low p-MBL levels …
View article: Polygenic Risk Score Prediction for Endometriosis
Polygenic Risk Score Prediction for Endometriosis Open
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization. Clinical tools to better identify candidates for laparoscopy-guided diag…
View article: Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke
Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke Open
In conclusion, we suggest that LCP PRMs are associated with the risk of developing IS, and may also participate in pathological events leading to post-ischemic brain damage. This study emphasizes the important contribution of alterations o…
View article: Severe antibody‐mediated transfusion‐related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non‐transfused male blood donor
Severe antibody‐mediated transfusion‐related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non‐transfused male blood donor Open
Transfusion‐Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life‐threatening TRALI in an obstetric patient triggered by transfusion from a non‐tran…
View article: HLA-DRB1 polymorphism in recurrent pregnancy loss: New evidence for an association to HLA-DRB1*07
HLA-DRB1 polymorphism in recurrent pregnancy loss: New evidence for an association to HLA-DRB1*07 Open
Many cases of recurrent pregnancy loss (RPL) defined as ≥3 consecutive pregnancy losses are suggested to be caused by an aberrant maternal immune response against the fetus or trophoblast. Human leukocyte antigen (HLA)-DRB1 and -DQB1 polym…
View article: Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study
Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study Open
View article: Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients
Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients Open
Background Autoimmune neutropenia of infancy (AIN) is a frequent cause of neutropenia in children. The disease is caused by antibodies against epitopes on the immunoglobulin G (IgG) Fc receptor type 3b (FcγIIIb). We investigated the possib…
View article: Author response for "Association between human leukocyte antigens (hlas) and human neutrophil antigens (hnas) and autoimmune neutropenia of infancy in danish patients"
Author response for "Association between human leukocyte antigens (hlas) and human neutrophil antigens (hnas) and autoimmune neutropenia of infancy in danish patients" Open
View article: Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing Open