Ryosuke Okamura
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View article: Artificial intelligence-supported system of surgical anatomy recognition may facilitate the understanding of gastrointestinal surgery for medical students
Artificial intelligence-supported system of surgical anatomy recognition may facilitate the understanding of gastrointestinal surgery for medical students Open
View article: Protocol for a study to evaluate the safety and efficacy of prophylactic negative pressure wound therapy after abdominal perineal resection (VACPAC study)
Protocol for a study to evaluate the safety and efficacy of prophylactic negative pressure wound therapy after abdominal perineal resection (VACPAC study) Open
Introduction Abdominal perineal resection (APR) is a surgical procedure for rectal cancer that frequently results in perineal wound surgical site infections (SSI), particularly in high-risk patients undergoing preoperative treatment. SSI a…
View article: Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study
Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study Open
Introduction: This study aimed to evaluate safety and feasibility of perioperative exercise and nutrition therapy and to explore perioperative changes in skeletal muscle mass (SMM) in patients with esophageal cancer. Methods: Patients sche…
View article: Gene- and immune-targeted therapy combinations using dual-matched biomarkers for patient selection
Gene- and immune-targeted therapy combinations using dual-matched biomarkers for patient selection Open
Combinations of gene-targeted therapy and immune checkpoint inhibitors (ICIs) have been conducted, though generally without biomarker-based patient selection for both therapy types. We evaluated outcomes of 17 patients with advanced cancer…
View article: Safety, compliance, and efficacy of prehabilitation in obese patients with gastric cancer undergoing minimally invasive gastrectomy: A pilot prospective study
Safety, compliance, and efficacy of prehabilitation in obese patients with gastric cancer undergoing minimally invasive gastrectomy: A pilot prospective study Open
Background: Excessive visceral fat area is a risk factor for postoperative complications in gastric cancer patients undergoing minimally invasive gastrectomy. This prospective pilot study aimed to evaluate the safety, compliance, and effic…
View article: Subtotal Gastrectomy for Clinical Stage I Remnant Gastric Cancer
Subtotal Gastrectomy for Clinical Stage I Remnant Gastric Cancer Open
Background Subtotal gastrectomy (SG) is a surgical option for early remnant gastric cancer (RGC). However, reports evaluating the feasibility and oncological safety of SG for RGC are limited. Here, we aimed to evaluate the short‐ and long‐…
View article: Initial Clinical Experience of Robot‐Assisted Rectal Surgery by Using <scp>Hugo RAS</scp> System: Horizontal Line Port Placement With Contralateral Reserve Arm Manipulation
Initial Clinical Experience of Robot‐Assisted Rectal Surgery by Using <span>Hugo RAS</span> System: Horizontal Line Port Placement With Contralateral Reserve Arm Manipulation Open
The benefits and advantages of robot‐assisted laparoscopic surgery (RALS) over conventional laparoscopic surgery are reported in many fields. Hugo RAS system is one of the newest surgical robots; it features a modular‐type robot with four …
View article: Robot-Assisted Total Proctocolectomy for Familial Adenomatous Polyposis with Multiple Colorectal Cancers Using the Hugo RAS System
Robot-Assisted Total Proctocolectomy for Familial Adenomatous Polyposis with Multiple Colorectal Cancers Using the Hugo RAS System Open
Robot-assisted TPC using the Hugo RAS system is safe and feasible. The flexibility of Hugo, which is carried by a modular-type surgical robot with multiple independent arms, enables safe and effective advanced procedures.
View article: Mediastinoscopy-Assisted Esophagectomy as an Effective Treatment for IgG4-Related Esophageal Stenosis: A Case Report.
Mediastinoscopy-Assisted Esophagectomy as an Effective Treatment for IgG4-Related Esophageal Stenosis: A Case Report. Open
This case underscores that IgG4-RD should be considered in the differential diagnosis of refractory esophageal stenosis, even with initially inconclusive biopsies. While serum IgG4 measurement has low sensitivity, it is still recommended. …
View article: Risk factors for local recurrence in patients with clinical stage II/III low rectal cancer: A multicenter retrospective cohort study in Japan
Risk factors for local recurrence in patients with clinical stage II/III low rectal cancer: A multicenter retrospective cohort study in Japan Open
Background Identifying risk factors for local recurrence (LR) is pivotal in optimizing rectal cancer treatment. Total mesorectal excision (TME) and lateral lymph node dissection (LLND) are the standard treatment for advanced low rectal can…
View article: Molecular Tumor Board for Unicorns: Outcomes for rare and ultra-rare cancers using an N-of-One personalized treatment strategy
Molecular Tumor Board for Unicorns: Outcomes for rare and ultra-rare cancers using an N-of-One personalized treatment strategy Open
Treatment of rare/ultra-rare tumors is an unmet need due to a lack of standardized therapies and clinical trials. We developed the Molecular Tumor Board (MTB), a multidisciplinary team that integrates molecular profiling to generate person…
View article: Appendiceal neoplasms derived from appendiceal tip remnants following appendectomy: a report of two cases
Appendiceal neoplasms derived from appendiceal tip remnants following appendectomy: a report of two cases Open
View article: Midesophageal diverticulum with elevated intrabolus pressure: a case report
Midesophageal diverticulum with elevated intrabolus pressure: a case report Open
View article: Utility of articulating instruments as an alternative to robotic devices in laparoscopic right hemicolectomy
Utility of articulating instruments as an alternative to robotic devices in laparoscopic right hemicolectomy Open
View article: Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids
Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids Open
Background Liver injury associated with oxaliplatin (L‐OHP)‐based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery. To date, no definiti…
View article: Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage
Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage Open
Osteoprotegerin (OPG) is a secreted cytokine that functions as a decoy receptor for receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL). Anti-RANKL treatment for bone metastasis has been widely accepted for solid tumors. How…
View article: International Poster Session
International Poster Session Open
ESD is accepted as the major treatment for early esophageal neoplasms and Hybridknife as an new endoscopic knife with high pressure needle free injection.To analyze our clinical outcomes of ESD with Hybridknife for esophageal neoplasms, we…
View article: 371. THE FEASIBILITY OF MINIMALLY INVASIVE SALVAGE ESOPHAGECTOMY
371. THE FEASIBILITY OF MINIMALLY INVASIVE SALVAGE ESOPHAGECTOMY Open
Background The mortality of salvage esophagectomy following definitive chemoradiotherapy for esophageal cancer is reported to be high and the feasibility of a minimally invasive approach for salvage esophagectomy remains unknown. The aim o…
View article: Postoperative recurrence in locally advanced rectal cancer: how does neoadjuvant treatment affect recurrence pattern?
Postoperative recurrence in locally advanced rectal cancer: how does neoadjuvant treatment affect recurrence pattern? Open
View article: Supplement Tables and Figures from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness
Supplement Tables and Figures from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness Open
Supplemental Tables 1-3 and Supplemental Figures 1-5
View article: Supplement Tables and Figures from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness
Supplement Tables and Figures from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness Open
Supplemental Tables 1-3 and Supplemental Figures 1-5
View article: Data from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness
Data from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness Open
Advanced and metastatic squamous cell carcinomas (SCC) are common and difficult-to-treat malignancies. We assessed 75 immunotherapy-treated patients with SCC from a clinically annotated database of 2,651 patients, as well as 9,407 patients…
View article: Data from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness
Data from Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness Open
Advanced and metastatic squamous cell carcinomas (SCC) are common and difficult-to-treat malignancies. We assessed 75 immunotherapy-treated patients with SCC from a clinically annotated database of 2,651 patients, as well as 9,407 patients…
View article: Supplementary Figure 5 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers
Supplementary Figure 5 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers Open
Supplementary Figure 5
View article: Supplementary Figure 4 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers
Supplementary Figure 4 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers Open
Supplementary Figure 4
View article: Supplementary Table from Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics
Supplementary Table from Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics Open
Supplementary Table
View article: Supplementary Tables from Survival Implications of the Relationship between Tissue versus Circulating Tumor DNA <i>TP53</i> Mutations—A Perspective from a Real-World Precision Medicine Cohort
Supplementary Tables from Survival Implications of the Relationship between Tissue versus Circulating Tumor DNA <i>TP53</i> Mutations—A Perspective from a Real-World Precision Medicine Cohort Open
Supplementary Tables
View article: Data from Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics
Data from Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics Open
Molecular profiling of circulating tumor DNA (ctDNA) is a promising noninvasive tool. Here, next-generation sequencing (NGS) of blood-derived ctDNA was performed in patients with advanced colorectal cancer. We investigated ctDNA-derived ge…
View article: Supplementary Figure 5 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers
Supplementary Figure 5 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers Open
Supplementary Figure 5
View article: Supplementary Figure 3 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers
Supplementary Figure 3 from High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers Open
Supplementary Figure 3