Rakesh P. Patel
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View article: 2-chlorofatty acid modification of neutrophil proteins: identification, localization and role in NETosis
2-chlorofatty acid modification of neutrophil proteins: identification, localization and role in NETosis Open
We previously demonstrated neutrophil MPO derived HOCl targets the vinyl ether bond of plasmalogens resulting in the Liberation of 2-chlorofatty aldehydes (2-ClFALDs) and their oxidation products, 2-chlorofatty acids (2-ClFAs), which elici…
View article: Interventional Radiology for Delayed Post-Pancreatectomy Hemorrhage: A Case Report and Review of the Literature
Interventional Radiology for Delayed Post-Pancreatectomy Hemorrhage: A Case Report and Review of the Literature Open
View article: Machine learning insights into vaccine adjuvants and immune outcomes
Machine learning insights into vaccine adjuvants and immune outcomes Open
Adjuvants boost the immune response to vaccine antigens, serving as key components in safe and effective vaccines. However, selecting a suitable adjuvant for a new vaccine can be challenging. This is due to the wide variety of adjuvants an…
View article: Nitrate reduction by salivary bacteria, glucose metabolism, and lifestyle
Nitrate reduction by salivary bacteria, glucose metabolism, and lifestyle Open
Nitrate reduction by salivary bacteria is inversely associated with insulin resistance and can be modulated by lifestyle factors. This knowledge could lead to the development of novel, non-invasive approaches for monitoring and preventing …
View article: Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform
Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform Open
Background: There is an unmet medical need to develop a vaccine targeting endemic coronaviruses. Antigen-specific monoclonal antibodies (mAbs) are crucial for many assays to support vaccine development. Objective: In this study, we used th…
View article: Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study
Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study Open
Introduction Regular use of mouthwash can disrupt nitrate reduction by oral bacteria and may affect systemic nitric oxide (NO) levels, which are important for inflammation and endothelial function. We aim to assess the association between …
View article: Association of Erythrocyte Hemolysis Products and Kidney Injury During Neonatal Cardiac Surgery
Association of Erythrocyte Hemolysis Products and Kidney Injury During Neonatal Cardiac Surgery Open
Background/Objectives: Hemolysis has been associated with acute kidney injury (AKI) in infants and neonates after surgery involving cardiopulmonary bypass (CPB). Erythrocyte hemolysis and subsequent end-organ injury have been shown to be a…
View article: 2-Chloro- and 2-Bromopalmitic acids inhibit mitochondrial function in airway epithelial cells
2-Chloro- and 2-Bromopalmitic acids inhibit mitochondrial function in airway epithelial cells Open
2-Chloropalmitic acid (2-ClPA) and 2-bromopalmitic acid (2-BrPa) increase in inflammatory lung disease associated with formation of hypochlorous or hypobromous acid, and exposure to halogen gases. Moreover, these lipids may elicit cell res…
View article: Biomarkers to Differentiate Acute Chest Syndrome From Vaso‐Occlusive Crisis in Children With Sickle Cell Disease
Biomarkers to Differentiate Acute Chest Syndrome From Vaso‐Occlusive Crisis in Children With Sickle Cell Disease Open
Background Acute Chest Syndrome (ACS) is the leading cause of death in children with sickle cell disease (SCD) in the US—about half of the children who develop ACS present initially with pain. Methods Here, we studied biomarkers to differe…
View article: The Effects of Acute Beetroot Juice Intake on Glycemic and Blood Pressure Responses When Controlling for Medication in Individuals with Type 2 Diabetes: A Pilot Study
The Effects of Acute Beetroot Juice Intake on Glycemic and Blood Pressure Responses When Controlling for Medication in Individuals with Type 2 Diabetes: A Pilot Study Open
Physical inactivity and poor dietary choices contribute to the rise in cardiometabolic diseases in the United States. It remains critical to identify strategies that may mitigate the negative impact of these behaviors. Several studies have…
View article: Migrainous vertigo impairs adaptive learning as a function of uncertainty
Migrainous vertigo impairs adaptive learning as a function of uncertainty Open
Objective In this study, we examined whether vestibular migraine, as a source of increased perceptual uncertainty due to the associated dizziness, interferes with adaptive learning. Methods The IOWA gambling task (IGT) was used to assess a…
View article: Tyrer-Cuzick Lifetime Risk is Not Associated with Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma
Tyrer-Cuzick Lifetime Risk is Not Associated with Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma Open
Purpose: The Tyrer-Cuzick lifetime risk score (TC LR) is used to estimate the probability of an unaffected female patient developing breast cancer as well as their likelihood of carrying a BRCA1/BRCA2 pathogenic variant (PV), considering f…
View article: Differentially co‐expressed myofibre transcripts associated with abnormal myofibre proportion in chronic obstructive pulmonary disease
Differentially co‐expressed myofibre transcripts associated with abnormal myofibre proportion in chronic obstructive pulmonary disease Open
Background Skeletal muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). Alterations in skeletal muscle myosin heavy chain expression, with reduced type I and increased type II myosin…
View article: Navigating the Incidence of Postoperative Arrhythmia and Hospitalization Length: The Role of Amiodarone and Other Antiarrhythmics in Prophylaxis
Navigating the Incidence of Postoperative Arrhythmia and Hospitalization Length: The Role of Amiodarone and Other Antiarrhythmics in Prophylaxis Open
Antiarrhythmic drugs play a pivotal role in managing and preventing arrhythmias. Amiodarone, classified as a class III antiarrhythmic, has been used prophylactically to effectively prevent atrial fibrillation postoperatively in cardiac sur…
View article: Advancing Breast Cancer Research Through Collaborative Computing: Harnessing Google Colab for Innovation
Advancing Breast Cancer Research Through Collaborative Computing: Harnessing Google Colab for Innovation Open
This investigation explores the potential efficacy of machine learning algorithms (MLAs), particularly convolutional neural networks (CNNs), in distinguishing between benign and malignant breast cancer tissue through the analysis of 1000 b…
View article: Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury Open
We established a swine model of chlorine gas-induced acute lung injury that exhibits several features of human acute lung injury and is suitable for screening potential medical countermeasures. We validated chlorinated fatty acids and prot…
View article: Expression of E-cadherin and N-cadherin in Epithelial-to-Mesenchymal Transition of Osteosarcoma: A Systematic Review
Expression of E-cadherin and N-cadherin in Epithelial-to-Mesenchymal Transition of Osteosarcoma: A Systematic Review Open
Osteosarcoma (OS) is a debilitating cancer of the bone that commonly afflicts the young and old. This may be de novo or associated with tumorigenic syndromes. However, many molecular mechanisms are still being uncovered and may offer great…
View article: Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation
Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation Open
View article: Formulation and Evaluation of Microsponge Gel for Topical Delivery of Antifungal Drug
Formulation and Evaluation of Microsponge Gel for Topical Delivery of Antifungal Drug Open
The quasi emulsion solvent diffusion technique was used to create the clotrimazole microsponges, which were eventually recognized as an efficient carrier for the topical delivery of the medicine. The characteristics of the created system w…
View article: Formulation and evaluation of immediate release tablet of Cisapride
Formulation and evaluation of immediate release tablet of Cisapride Open
The term “immediate release” pharmaceutical formulation includes any formulation in which the rate of release of drug from the formulation or the absorption of drug, is neither appreciably, nor intentionally, retarded by galenic manipulati…
View article: Acute beetroot juice reduces blood pressure in young Black and White males but not females
Acute beetroot juice reduces blood pressure in young Black and White males but not females Open
View article: Formulation and evaluation of immediate release tablet of Cisapride
Formulation and evaluation of immediate release tablet of Cisapride Open
The term “immediate release” pharmaceutical formulation includes any formulation in which the rate of release of drug from the formulation or the absorption of drug, is neither appreciably, nor intentionally, retarded by galenic manipulati…
View article: Exploring the Role of External Beam Radiation Therapy in Osteosarcoma Treatment: Impact of Diagnostic Imaging Delays and Innovative Techniques
Exploring the Role of External Beam Radiation Therapy in Osteosarcoma Treatment: Impact of Diagnostic Imaging Delays and Innovative Techniques Open
Osteosarcomas are a type of bone cancer that typically affect young adults, often in the bones of the arms and legs. To treat osteosarcoma, doctors typically use a combination of chemotherapy, radiotherapy, and surgery, with External Beam …
View article: Table S5 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk
Table S5 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk Open
DS Group Classification within Select Clinicopathologic Factors
View article: Figure S4 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk
Figure S4 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk Open
Figure S4. Multivariate Analysis of Clinicopathologic and Molecular Factors Excluding Patients with Positive Margins for 10 Year IBE Risk
View article: Figure S2 from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy
Figure S2 from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy Open
Association of DS and clinicopathologic factors and treatment with ipsilateral breast event risks, forest plot of a multivariate analysis
View article: Table S6 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk
Table S6 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk Open
Analysis of Linear Model at Selected Thresholds
View article: Supplementary Methods from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy
Supplementary Methods from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy Open
Supplementary Methods
View article: Figure S3 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk
Figure S3 from A Biological Signature for Breast Ductal Carcinoma <i>In Situ</i> to Predict Radiotherapy Benefit and Assess Recurrence Risk Open
Figure S3. Baseline Risks as a Function of Year of Diagnosis
View article: Table S3 from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy
Table S3 from Validation of a Ductal Carcinoma <i>In Situ</i> Biomarker Profile for Risk of Recurrence after Breast-Conserving Surgery with and without Radiotherapy Open
10-year total breast event risk for patients treated with radiation therapy and optionally with endocrine therapy compared to those with no endocrine therapy, by DS risk groups