Robert K. Poole
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View article: Interpreting the role of antioxidants in vivo: A cautionary tale
Interpreting the role of antioxidants in vivo: A cautionary tale Open
Bacteria have a remarkable ability to sense environmental stresses and to respond to these stressors by adapting their metabolism and physiology. In recent publications, investigators have suggested that multiple stresses that cause cell d…
View article: The manganese carbonyl complex [Mn(CO)3(tqa-κ3N)]Br: A novel antimicrobial agent with the potential to treat avian pathogenic Escherichia coli (APEC) infections
The manganese carbonyl complex [Mn(CO)3(tqa-κ3N)]Br: A novel antimicrobial agent with the potential to treat avian pathogenic Escherichia coli (APEC) infections Open
The development of alternatives to antibiotics is essential for the treatment of animal infections and as a measure to reduce the selective pressure on antibiotics that are critical for human medicine. Metal complexes have been highlighted…
View article: The Evolution of Nitric Oxide Function: From Reactivity in the Prebiotic Earth to Examples of Biological Roles and Therapeutic Applications
The Evolution of Nitric Oxide Function: From Reactivity in the Prebiotic Earth to Examples of Biological Roles and Therapeutic Applications Open
Nitric oxide was once considered to be of marginal interest to the biological sciences and medicine; however, there is now wide recognition, but not yet a comprehensive understanding, of its functions and effects. NO is a reactive, toxic f…
View article: CORM-3 induces DNA damage through Ru(II) binding to DNA
CORM-3 induces DNA damage through Ru(II) binding to DNA Open
When the ‘CO-releasing molecule-3’, CORM-3 (Ru(CO)3Cl(glycinate)), is dissolved in water it forms a range of ruthenium complexes. These are taken up by cells and bind to intracellular ligands, notably thiols such as cysteine and glutathion…
View article: ‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects
‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects Open
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in biological chemistry and biomedicine. CORMs kill bacteria in culture and in animal models, but are reportedly benign towards mammal…
View article: Role of Carbon Monoxide in Host–Gut Microbiome Communication
Role of Carbon Monoxide in Host–Gut Microbiome Communication Open
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system…
View article: Bacterial Oxidases of the Cytochrome<i>bd</i>Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets
Bacterial Oxidases of the Cytochrome<i>bd</i>Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets Open
Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular o…
View article: Antibacterial activity of Mn(<scp>i</scp>) and Re(<scp>i</scp>) tricarbonyl complexes conjugated to a bile acid carrier molecule
Antibacterial activity of Mn(<span>i</span>) and Re(<span>i</span>) tricarbonyl complexes conjugated to a bile acid carrier molecule Open
A bifunctional cholic acid–bis(2-pyridylmethyl)amine (bpa) ligand featuring an amide linker was coordinated to a manganese(i) or rhenium(i) tricarbonyl moiety to give [M(bpacholamide)(CO)3] with M = Mn, Re in good yield and very high purit…
View article: A microbubble-sparged yeast propagation–fermentation process for bioethanol production
A microbubble-sparged yeast propagation–fermentation process for bioethanol production Open
Background Industrial biotechnology will play an increasing role in creating a more sustainable global economy. For conventional aerobic bioprocesses supplying O 2 can account for 15% of total production costs. Microbubbles (MBs) are micro…
View article: CCDC 1909283: Experimental Crystal Structure Determination
CCDC 1909283: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Flavohaemoglobin: the pre-eminent nitric oxide–detoxifying machine of microorganisms
Flavohaemoglobin: the pre-eminent nitric oxide–detoxifying machine of microorganisms Open
Flavohaemoglobins were first described in yeast as early as the 1970s but their functions were unclear. The surge in interest in nitric oxide biology and both serendipitous and hypothesis-driven discoveries in bacterial systems have transf…
View article: Additional file 2 of A microbubble-sparged yeast propagation–fermentation process for bioethanol production
Additional file 2 of A microbubble-sparged yeast propagation–fermentation process for bioethanol production Open
Additional file 2. Microarray fold changes.
View article: Additional file 3 of A microbubble-sparged yeast propagation–fermentation process for bioethanol production
Additional file 3 of A microbubble-sparged yeast propagation–fermentation process for bioethanol production Open
Additional file 3. RNA-seq fold changes.
View article: Faculty Opinions recommendation of An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization.
Faculty Opinions recommendation of An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization. Open
Nitric oxide (NO•) is a ubiquitous molecular mediator in biology. Many signalling actions of NO• generated by mammalian NO• synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environme…
View article: Faculty Opinions recommendation of Salmonella reprograms nucleotide metabolism in its adaptation to nitrosative stress.
Faculty Opinions recommendation of Salmonella reprograms nucleotide metabolism in its adaptation to nitrosative stress. Open
The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric oxide (NO) engendered in the immune response are incompletely understood. We show here that salmonellae experiencing nitrosative stress suffer dramat…
View article: Faculty Opinions recommendation of Nitric Oxide-Mediated Induction of Dispersal in Pseudomonas aeruginosa Biofilms Is Inhibited by Flavohemoglobin Production and Is Enhanced by Imidazole.
Faculty Opinions recommendation of Nitric Oxide-Mediated Induction of Dispersal in Pseudomonas aeruginosa Biofilms Is Inhibited by Flavohemoglobin Production and Is Enhanced by Imidazole. Open
Read the full review for this Faculty Opinions recommended article: Nitric Oxide-Mediated Induction of Dispersal in Pseudomonas aeruginosa Biofilms Is Inhibited by Flavohemoglobin Production and Is Enhanced by Imidazole.
View article: Improvement of Acetaldehyde Production in Zymomonas mobilis by Engineering of Its Aerobic Metabolism
Improvement of Acetaldehyde Production in Zymomonas mobilis by Engineering of Its Aerobic Metabolism Open
Acetaldehyde is a valuable product of microbial biosynthesis, which can be used by the chemical industry as the entry point for production of various commodity chemicals. In ethanologenic microorganisms, like yeast or the bacterium Zymo…
View article: Biological activity of manganese(<scp>i</scp>) tricarbonyl complexes on multidrug-resistant Gram-negative bacteria: From functional studies to <i>in vivo</i> activity in <i>Galleria mellonella</i>
Biological activity of manganese(<span>i</span>) tricarbonyl complexes on multidrug-resistant Gram-negative bacteria: From functional studies to <i>in vivo</i> activity in <i>Galleria mellonella</i> Open
Antibacterial activity of four Mn(CO)3 complexes on multidrug-resistant clinical isolates of A. baumannii and P. aeruginosa correlated with lipophilicity and increase in ATP release. Absence of host toxicity in G. mellonella was…
View article: Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator
Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator Open
Britton Chance, electronics expert when a teenager, became an enthusiastic student of biological oscillations, passing on this enthusiasm to many students and colleagues, including one of us (DL). This historical essay traces BC's influenc…
View article: Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria?
Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria? Open
A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antim…
View article: A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3 Open
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds, are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in mammalian systems. CORMs are also explored as potential novel a…
View article: CCDC 1558934: Experimental Crystal Structure Determination
CCDC 1558934: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1559396: Experimental Crystal Structure Determination
CCDC 1559396: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, isomerisation and biological properties of mononuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand
Synthesis, isomerisation and biological properties of mononuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand Open
The strained complexes cis-β-[Ru(phen′)(bb7)]2+ isomerise to the corresponding cis-α isomers, with cis-α-[Ru(Me4phen)(bb7)]2+ showing good antibacterial activity.
View article: Listeria monocytogenes has both a bd-type and an aa3 -type terminal oxidase which allow growth in different oxygen levels and both are important in infection
Listeria monocytogenes has both a bd-type and an aa3 -type terminal oxidase which allow growth in different oxygen levels and both are important in infection Open
Listeria monocytogenes is a food borne pathogen responsible for a number of life-threatening infections of humans. During an infection it invades epithelial cells before spreading from the intestine to the cells of the liver and spleen. Th…
View article: Antimicrobial activity of carbon monoxide-releasing molecule [Mn(CO)3(tpa-κ3N)]Br versus multidrug-resistant isolates of Avian Pathogenic Escherichia coli and its synergy with colistin
Antimicrobial activity of carbon monoxide-releasing molecule [Mn(CO)3(tpa-κ3N)]Br versus multidrug-resistant isolates of Avian Pathogenic Escherichia coli and its synergy with colistin Open
Antimicrobial resistance is a growing global concern in human and veterinary medicine, with an ever-increasing void in the arsenal of clinicians. Novel classes of compounds including carbon monoxoide-releasing molecules (CORMs), for exampl…
View article: A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3 N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli
A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3 N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli Open
Carbon monoxide-releasing molecules (CORMs) are a promising class of new antimicrobials, with multiple modes of action that are distinct from those of standard antibiotics. The relentless increase in antimicrobial resistance, exacerbated b…
View article: Transcriptome and proteome dynamics in chemostat culture reveal how <i>Campylobacter jejuni</i> modulates metabolism, stress responses and virulence factors upon changes in oxygen availability
Transcriptome and proteome dynamics in chemostat culture reveal how <i>Campylobacter jejuni</i> modulates metabolism, stress responses and virulence factors upon changes in oxygen availability Open
Summary Campylobacter jejuni , the most frequent cause of food‐borne bacterial gastroenteritis worldwide, is a microaerophile that has to survive high environmental oxygen tensions, adapt to oxygen limitation in the intestine and resist ho…
View article: The Broad-Spectrum Antimicrobial Potential of [Mn(CO)<sub>4</sub>(S<sub>2</sub>CNMe(CH<sub>2</sub>CO<sub>2</sub>H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization
The Broad-Spectrum Antimicrobial Potential of [Mn(CO)<sub>4</sub>(S<sub>2</sub>CNMe(CH<sub>2</sub>CO<sub>2</sub>H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization Open
CORM-401, contrary to our expectations of a CO delivery vehicle, does not inhibit respiration. It accumulates in the cytoplasm, acts like an uncoupler in disrupting cytoplasmic ion balance, and triggers multiple effects, including osmotic …
View article: The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection
The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection Open