Rupert Purchase
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View article: Removal of Toxic Metabolites—Chelation: Manganese Disorders
Removal of Toxic Metabolites—Chelation: Manganese Disorders Open
Manganese (Mn) overload is a characteristic of multiple disease entities, from acquired manganism upon environmental or occupational overexposure, to end‐stage liver disease and certain genetic disorders. The latter include hypermanganesae…
View article: The different names used for trientine and triethylenetetramine
The different names used for trientine and triethylenetetramine Open
Approved, colloquial, trade and code names for the copper chelating agent triethylenetetramine and two of its salts are explained.
View article: The production of pharmaceutical grade trientine dihydrochloride for the treatment of Wilson’s disease: a personal account
The production of pharmaceutical grade trientine dihydrochloride for the treatment of Wilson’s disease: a personal account Open
This article describes the background to the production of trientine dihydrochloride for the treatment of Wilson's disease.
View article: Sir John Cornforth Ac Cbe Frs: His Biosynthetic Work
Sir John Cornforth Ac Cbe Frs: His Biosynthetic Work Open
Sir John Cornforth's work on the stereochemistry of enzyme reactions involved in the biosynthesis of squalene and cholesterol and in the formation and metabolism of a chiral methyl group in acetyl co-enzyme A, is reviewed.
View article: Sir John Cornforth Ac Cbe Frs: His Synthetic Work
Sir John Cornforth Ac Cbe Frs: His Synthetic Work Open
Sir John Cornforth's work on the synthesis of cholesterol and penicillamine, on the chemistry of oxazoles, the stereochemistry of the synthesis of alkenes, the synthesis of abscisic acid and of dibenzophospholes as mimics of enzyme action,…
View article: Sir John and Lady Rita Cornforth: A Distinguished Chemical Partnership
Sir John and Lady Rita Cornforth: A Distinguished Chemical Partnership Open
This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead La…