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View article: Draft genome sequence of the HP60 serovar of <i>Avibacterium paragallinarum</i>
Draft genome sequence of the HP60 serovar of <i>Avibacterium paragallinarum</i> Open
Infectious coryza, caused by Avibacterium paragallinarum , poses a challenge for poultry farms due to the inefficacy of vaccines. The genome of A. paragallinarum serovar HP60, which belongs to the C-serogroup, was sequenced to enable compa…
View article: Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease
Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease Open
While progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington's disease (HD), the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-s…
View article: Avibacterium paragallinarum, the Causative Agent of Infectious Coryza: A Comprehensive Review
Avibacterium paragallinarum, the Causative Agent of Infectious Coryza: A Comprehensive Review Open
Infectious coryza (IC) caused by Avibacterium paragallinarum (AP) has risen in importance as a poultry disease over the past several years because of its increased incidence in commercial poultry in both Europe and the United States…
View article: Impact of the Stress Response on Quaternary Ammonium Compound Disinfectant Susceptibility in Serratia Species
Impact of the Stress Response on Quaternary Ammonium Compound Disinfectant Susceptibility in Serratia Species Open
The well-known problem of antibiotic resistance foreshadows a similar threat posed by microbial resistance to biocides such as disinfectants and antiseptics. These products are vital for infection control, yet their overuse during the COVI…
View article: Hereditary spastic paraplegia with thin corpus callosum and <scp><i>SPG11</i></scp> mutation: A neuropathological evaluation
Hereditary spastic paraplegia with thin corpus callosum and <span><i>SPG11</i></span> mutation: A neuropathological evaluation Open
Hereditary spastic paraplegia (HSP) with thin corpus callosum can be due to a variety of genetic causes, the most common of which are biallelic variants in SPG11 (HSP11). Only six cases of neuropathologic examination of HSP11 have been rep…
View article: Differential Expression Analysis Reveals Possible New Quaternary Ammonium Compound Resistance Gene in Highly Resistant Serratia sp. HRI
Differential Expression Analysis Reveals Possible New Quaternary Ammonium Compound Resistance Gene in Highly Resistant Serratia sp. HRI Open
During the COVID-19 pandemic, the surge in disinfectant use emphasised their pivotal role in infection control. While the majority of antimicrobial resistance research focuses on antibiotics, resistance to biocides, which are present in di…
View article: Microscopy Techniques Unveil the Effect of Qac-Disinfectants on Biofilm Formation, Cell Morphology, and Localisation of Qac Compounds
Microscopy Techniques Unveil the Effect of Qac-Disinfectants on Biofilm Formation, Cell Morphology, and Localisation of Qac Compounds Open
View article: The Hormetic Effect Observed for Benzalkonium Chloride and Didecyldimethylammonium Chloride in Serratia sp. HRI
The Hormetic Effect Observed for Benzalkonium Chloride and Didecyldimethylammonium Chloride in Serratia sp. HRI Open
Hormesis, or the hormetic effect, is a dose- or concentration-dependent response characterised by growth stimulation at low concentrations and inhibition at high concentrations. The impact of sub-lethal levels of disinfectants on the growt…
View article: Genomic Islands Identified in Highly Resistant Serratia sp. HRI: A Pathway to Discover New Disinfectant Resistance Elements
Genomic Islands Identified in Highly Resistant Serratia sp. HRI: A Pathway to Discover New Disinfectant Resistance Elements Open
Molecular insights into the mechanisms of resistance to disinfectants are severely limited, together with the roles of various mobile genetic elements. Genomic islands are a well-characterised molecular resistance element in antibiotic res…
View article: Susceptibility Tests and Predictions of Transporter Profile in Serratia Species
Susceptibility Tests and Predictions of Transporter Profile in Serratia Species Open
Disinfectants and biosecurity are critically important to control microbial diseases. Resistance to disinfectants compromises sectors such as agriculture and healthcare systems. Currently, efflux pumps are the most common mechanism of anti…
View article: Corrigendum to “Molecular basis of bacterial disinfectant resistance” [Drug Resist. Updates 48 (2020) 100672]
Corrigendum to “Molecular basis of bacterial disinfectant resistance” [Drug Resist. Updates 48 (2020) 100672] Open
View article: Molecular Tools for the Study of Resistance to Disinfectants
Molecular Tools for the Study of Resistance to Disinfectants Open
Disinfectants, antiseptics, and sanitizers are crucial for hygiene standards and disease control, as recently emphasized by the SARS-CoV-2 (COVID-19) pandemic. With the foreshadowing of antibiotic resistance, new cutting-edge technologies …
View article: Huntingtin lowering reduces somatic instability at CAG-expanded loci
Huntingtin lowering reduces somatic instability at CAG-expanded loci Open
Expanded trinucleotide repeats cause many human diseases, including Huntington’s disease (HD). Recent studies indicate that somatic instability of these repeats contributes to pathogenesis in several expansion disorders. We find that lower…
View article: Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse Models
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse Models Open
Progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington’s disease (HD), but the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-seq…
View article: Genome Sequence of Resistant <i>Serratia</i> sp. Strain HRI, Isolated from a Bottle of Didecyldimethylammonium Chloride-Based Disinfectant
Genome Sequence of Resistant <i>Serratia</i> sp. Strain HRI, Isolated from a Bottle of Didecyldimethylammonium Chloride-Based Disinfectant Open
Antimicrobial resistance is a significant issue, and it threatens the prevention and effective treatment of a range of bacterial infections. Here, we report the whole-genome sequence of the multidrug-resistant isolate Serratia sp. strain H…
View article: Molecular basis of bacterial disinfectant resistance
Molecular basis of bacterial disinfectant resistance Open
Antibiotic resistance could accelerate humanity towards an already fast-approaching post-antibiotic era, where disinfectants and effective biosecurity measures will be critically important to control microbial diseases. Disinfectant resist…
View article: Regulation of outer-membrane proteins (OMPs) A and F, during hlyF-induced outer-membrane vesicle (OMV) biosynthesis
Regulation of outer-membrane proteins (OMPs) A and F, during hlyF-induced outer-membrane vesicle (OMV) biosynthesis Open
View article: Detection of virulence factors of South African Lactococcus garvieae isolated from rainbow trout, Oncorhynchus mykiss (Walbaum)
Detection of virulence factors of South African Lactococcus garvieae isolated from rainbow trout, Oncorhynchus mykiss (Walbaum) Open
Lactococcus garvieae is a Gram-positive bacterium that causes mortalities in freshwater and marine fish worldwide and therefore results in severe economic losses in the aquaculture industry. Apart from the apparent integral role of the exo…
View article: The Use of Phage Display and Yeast Based Expression System for the Development of a Von Willebrand Factor Propeptide Assay: Development of a Von Willebrand Factor Propeptide Assay
The Use of Phage Display and Yeast Based Expression System for the Development of a Von Willebrand Factor Propeptide Assay: Development of a Von Willebrand Factor Propeptide Assay Open
Background. The diagnosis of von Willebrand disease is complex due to the heterogeneity of the disease. About eighty percent of von Willebrand disease patients are diagnosed with a quantitative defect of von Willebrand factor (VWF) where f…
View article: Modified Robucket Design
Modified Robucket Design Open
Instructions and associated files for modified ROBucket housing (mROBucket), as well as instructions for running a mouse through a progressive-ratio motivation task. "ROBucket Modification.pdf" is the instruction sheet for creating the mod…
View article: Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease
Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease Open
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neuropathological signature is the selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant pro…
View article: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease Open
We investigated the appearance and progression of disease-relevant signs in the B6. Htt Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (HD). We find that B6. Htt Q111/+ mice are healthy, show no …
View article: CCDC 1515629: Experimental Crystal Structure Determination
CCDC 1515629: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Peripheral<i>Htt</i>silencing does not ameliorate central signs of disease in the B6.<i>Htt<sup>Q111/+</sup></i>mouse model of Huntington’s Disease
Peripheral<i>Htt</i>silencing does not ameliorate central signs of disease in the B6.<i>Htt<sup>Q111/+</sup></i>mouse model of Huntington’s Disease Open
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease whose neuropathological signature is a selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (huntingt…
View article: Evaluation of the ERIC-PCR as a probable method to differentiate <i>Avibacterium paragallinarum</i> serovars
Evaluation of the ERIC-PCR as a probable method to differentiate <i>Avibacterium paragallinarum</i> serovars Open
Infectious coryza, an upper respiratory tract disease in chickens, caused by Avibacterium paragallinarum, leads to huge economic losses. The disease is controlled through vaccination; but vaccination efficacy is dependent on correct identi…
View article: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.<i>Htt</i><sup><i>Q111/+</i></sup>model of Huntington’s disease
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.<i>Htt</i><sup><i>Q111/+</i></sup>model of Huntington’s disease Open
We investigated the appearance and progression of disease-relevant signs in the B6. Htt Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (HD). We find that B6. Htt Q111/+ mice are healthy, show no …
View article: Isolation And Identification Of InfectiousPancreatic Necrosis Virus From Rainbow Trout (salmo Gairdneri Richardson) In South Africa
Isolation And Identification Of InfectiousPancreatic Necrosis Virus From Rainbow Trout (salmo Gairdneri Richardson) In South Africa Open