R. Rajendran
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View article: MAB Optimizer for Estimating Math Question Difficulty via Inverse CV without NLP
MAB Optimizer for Estimating Math Question Difficulty via Inverse CV without NLP Open
The evolution of technology and education is driving the emergence of Intelligent & Autonomous Tutoring Systems (IATS), where objective and domain-agnostic methods for determining question difficulty are essential. Traditional human labeli…
View article: Anti‐inflammatory and remyelinating effects of fexagratinib in experimental multiple sclerosis
Anti‐inflammatory and remyelinating effects of fexagratinib in experimental multiple sclerosis Open
Background and Purpose FGF, VEGFR‐2 and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG 35‐55 ‐induced experimental autoimmune encephalomyelitis …
View article: Anti-inflammatory and remyelinating effects of AZD4547 in experimental multiple sclerosis
Anti-inflammatory and remyelinating effects of AZD4547 in experimental multiple sclerosis Open
Background and Purpose: Fibroblast Growth Factor (FGF), VEGFR2, and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG35-55-induced EAE prevented se…
View article: Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy
Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy Open
Barth Syndrome (BTHS) is a rare X-linked disease, characterized clinically by cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the phospholipid acyltransferase tafazzin (Gene: TAFAZZIN,…
View article: The small molecule fibroblast growth factor receptor inhibitor infigratinib exerts anti‐inflammatory effects and remyelination in a model of multiple sclerosis
The small molecule fibroblast growth factor receptor inhibitor infigratinib exerts anti‐inflammatory effects and remyelination in a model of multiple sclerosis Open
Background and Purpose Fibroblast growth factors and receptors (FGFR) have been shown to modulate inflammation and neurodegeneration in multiple sclerosis (MS). The selective FGFR inhibitor infigratinib has been shown to be effective in ca…
View article: Interferon Beta-1a versus Combined Interferon Beta-1a and Oligodendrocyte-Specific FGFR1 Deletion in Experimental Autoimmune Encephalomyelitis
Interferon Beta-1a versus Combined Interferon Beta-1a and Oligodendrocyte-Specific FGFR1 Deletion in Experimental Autoimmune Encephalomyelitis Open
Recombinant beta interferons-1 (IFNβ-1) are used as first line therapies in patients with relapsing multiple sclerosis (MS), a chronic inflammatory and neurodegenerative disease of the CNS. IFNβ-1a/b has moderate effects on the prevention …
View article: Quantitative Lipidomic Analysis of Takotsubo Syndrome Patients' Serum
Quantitative Lipidomic Analysis of Takotsubo Syndrome Patients' Serum Open
Takotsubo syndrome (TTS), also known as the transient left ventricular apical ballooning syndrome, is in contemporary times known as novel acute cardiac syndrome. It is characterized by transient left ventricular apical akinesis and hyperk…
View article: Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE
Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE Open
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS). MS commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs significantly contribute to clinical di…
View article: Evidence of a Muscle–Brain Axis by Quantification of the Neurotrophic Myokine METRNL (Meteorin-Like Protein) in Human Cerebrospinal Fluid and Serum
Evidence of a Muscle–Brain Axis by Quantification of the Neurotrophic Myokine METRNL (Meteorin-Like Protein) in Human Cerebrospinal Fluid and Serum Open
Data on the quantification of the potentially neurotrophic adipo-myokine METRNL (Meteorin-like protein) in human cerebrospinal fluid (CSF) are lacking and migration of this secreted protein across the blood–brain barrier (BBB) is uncertain…
View article: Effects of FGFR Tyrosine Kinase Inhibition in OLN-93 Oligodendrocytes
Effects of FGFR Tyrosine Kinase Inhibition in OLN-93 Oligodendrocytes Open
Fibroblast growth factor (FGF) signaling is involved in the pathogenesis of multiple sclerosis (MS). Data from neuropathology studies suggest that FGF signaling contributes to the failure of remyelination in MS. In MOG35–55-induced EAE, ol…
View article: FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models
FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models Open
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) affecting more than two million people worldwide. In MS, oligodendrocytes and myelin sheaths are destroyed by autoimmune-me…
View article: Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG<sub>35‐55</sub>‐induced EAE through ERK and Akt signalling
Oligodendrocyte‐specific deletion of FGFR2 ameliorates MOG<sub>35‐55</sub>‐induced EAE through ERK and Akt signalling Open
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in demyelinating pathologies including multiple sclerosis (MS). In our recent study, oligodendrocyte‐specific deletion of FGFR1 resulted in a milder disease course, …
View article: Experimental Investigation on Hybrid Propulsion Technology to Increase Fuel Efficiency and Reduce Carbon Emission
Experimental Investigation on Hybrid Propulsion Technology to Increase Fuel Efficiency and Reduce Carbon Emission Open
Experimental Investigation on Hybrid Propulsion Technology to Increase Fuel Efficiency and Reduce Carbon Emission - written by Dr. R. Rajendran , Priya Darshini. S , Sanjay. N published on 2020/04/23 download full article with reference da…
View article: Frictional property evaluation of aluminium alloy based metal matrix composites under dry braking condition in pin—on—disc system
Frictional property evaluation of aluminium alloy based metal matrix composites under dry braking condition in pin—on—disc system Open
Aluminum alloy based metal matrix composites are widely used in aerospace, military and automotive industry. The aluminium grades used in present research work are Aluminium alloy 6061, Aluminium alloy 2024, LM6. In this research, composit…
View article: STUDY ON MECHANICAL BEHAVIOUR OF BANANA FIBER REINFORCED EPOXY COMPOSITES
STUDY ON MECHANICAL BEHAVIOUR OF BANANA FIBER REINFORCED EPOXY COMPOSITES Open
Field experiments were conducted to study the effect of orthosilicic acid formulations on leaf folder incidence in lowland rice at Experimental Farm, Annamalai University, Tamil Nadu, India, during Navarai and Samba seasons of 2017.The tre…
View article: Oligodendroglial fibroblast growth factor receptor 1 gene targeting protects mice from experimental autoimmune encephalomyelitis through <scp>ERK/AKT</scp> phosphorylation
Oligodendroglial fibroblast growth factor receptor 1 gene targeting protects mice from experimental autoimmune encephalomyelitis through <span>ERK/AKT</span> phosphorylation Open
Fibroblast growth factors (FGFs) exert diverse biological effects by binding and activation of specific fibroblast growth factor receptors (FGFRs). FGFs and FGFRs have been implicated in demyelinating pathologies including multiple scleros…
View article: Effective Optimization and Evaluation of Air Plasma Treatment on the Surface of 100% Bleached Cotton Fabric for Better Dabbing of Antibacterial Finishes
Effective Optimization and Evaluation of Air Plasma Treatment on the Surface of 100% Bleached Cotton Fabric for Better Dabbing of Antibacterial Finishes Open
The vital biological systems are sensitive and may react to the environmental factors with adverse effects. And so are the microorganisms, which invade in textile fabrics with conducive contaminations and have challenged the healthy life s…