Cléverton Roberto de Andrade
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View article: Sexual dimorphism of the ventral premammillary nucleus of the rat: stereological evaluation
Sexual dimorphism of the ventral premammillary nucleus of the rat: stereological evaluation Open
Background The ventral premammillary nucleus (PMv), situated within the ventrobasal hypothalamus, is sensitive to steroid hormones and is involved in pheromone-responsive circuits. It maintains robust connections with sexually dimorphic nu…
View article: Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo (Adv. Therap. 1/2025)
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo (Adv. Therap. 1/2025) Open
This image represents a hybrid nanoparticle, dispersed in a thermos-responsive hydrogel, composed of mesoporous silica nanoparticles and liposome-like structure dual-loaded with curcumin and benzydamine hydrochloride for the treatment of v…
View article: Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo Open
Vulvovaginal candidiasis represents a public health challenge due to its reports of high incidence and recurrence. These are caused by host‐related factors like compromised immune system, or pathogen‐related factors, such as resistance to …
View article: Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model
Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model Open
Colorectal cancer (CRC) is one of the top 10 most common cancers worldwide and caused approximately 10 million deaths in 2022. CRC mortality has increased by 10% since 2020 and 52.000 deaths will occur in 2024, highlighting the limitations…
View article: Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice
Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice Open
The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the presen…
View article: Candida albicans and Staphylococcus sp identify the presence of invasive and deep invasive squamous cell carcinoma induced by 4-nitroquiloline oxide
Candida albicans and Staphylococcus sp identify the presence of invasive and deep invasive squamous cell carcinoma induced by 4-nitroquiloline oxide Open
Purpose: Oral squamous cell carcinoma (OSCC) sum 90 to 95 percent of oral cancers and the incidence described men aged 40 to 60 years old. The greater risk factor is the use of tobacco and alcohol, and they are described in independent or …
View article: COMPARATIVE STUDY OF THE LIVER STRUCTURE BETWEEN YOUNG, ADULT AND ELDERLY RATS
COMPARATIVE STUDY OF THE LIVER STRUCTURE BETWEEN YOUNG, ADULT AND ELDERLY RATS Open
The aim of this study was to analyze the morphological aspects of the liver parenchyma components in three stages of age in Holtzman rats.The livers of 33 female rats (Rattus norvegicus albinus, Holtzman) aged 120 days (G1 -young), 180 day…
View article: Epidemiological profile and survival analysis of oral and oropharyngeal squamous cell carcinomas: a 10-year retrospective study
Epidemiological profile and survival analysis of oral and oropharyngeal squamous cell carcinomas: a 10-year retrospective study Open
The aim of this study is to identify the epidemiology profile of oral squamous cell carcinoma in a population of patients treated at the Bom Pastor FHOMUV Hospital of Varginha, in the state of Minas Gerais, Brazil. To this end, the medical…
View article: Negative Terpinen-4-ol Modulate Potentially Malignant and Malignant Lingual Lesions Induced by 4-Nitroquinoline-1-Oxide in Rat Model
Negative Terpinen-4-ol Modulate Potentially Malignant and Malignant Lingual Lesions Induced by 4-Nitroquinoline-1-Oxide in Rat Model Open
Purpose Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. Methods The stereoisomers of TP-4-ol were used against the human tongue squamous cell line and the negative stereoisomer sho…
View article: Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice
Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice Open
The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the presen…
View article: The preventive effect of Taurine in early stage of colon chemical carcinogenesis
The preventive effect of Taurine in early stage of colon chemical carcinogenesis Open
Colorectal cancer is one of the most common types of cancer in the world.The aberrant crypts foci are the first dysplastic alterations observed in colons in animal models and in human beings.Taurine is the most abundant semi-essential β-am…
View article: Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue
Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue Open
View article: The correlation of different methods for the assessment of bone quality in vivo: an observational study
The correlation of different methods for the assessment of bone quality in vivo: an observational study Open
View article: Evaluation of Alveolar Bone Quality: Correlation Between Histomorphometric Analysis and Lekholm and Zarb Classification
Evaluation of Alveolar Bone Quality: Correlation Between Histomorphometric Analysis and Lekholm and Zarb Classification Open
Objectives: This study evaluated the bone quality of the maxilla and mandible by using the classification proposed by Lekholm and Zarb (L & Z) and histomorphometry. Methods: Sixty edentulous areas were evaluated. The classification by L & …
View article: Effect of systemic ozone therapy as a biomodulator of tissue regeneration and inflammatory response in rats
Effect of systemic ozone therapy as a biomodulator of tissue regeneration and inflammatory response in rats Open
Introduction Among the therapeutic effects of ozone therapy, improvement in cell metabolism and peripheral tissue oxygenation have been highlighted. Objective to evaluate the systemic effect of bio-oxidative therapy with ozone gas on wound…
View article: Aqueous extract of<i>Paullinia cupana</i>attenuates renal and hematological effects associated with ketoprofen
Aqueous extract of<i>Paullinia cupana</i>attenuates renal and hematological effects associated with ketoprofen Open
This study aimed to evaluate the effect of aqueous extract of Paullinia cupana (AEG) against ketoprofen side effects, through biochemical, hematological, and histological parameters. AEG showed antioxidant activity in the DPPH• …
View article: Biomonitoring of workers occupationally exposed to hazardous condition: the importance of genotoxicity studies
Biomonitoring of workers occupationally exposed to hazardous condition: the importance of genotoxicity studies Open
View article: Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii Open
View article: Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review
Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review Open
Background: Periodontitis has been associated with several systemic diseases and medical conditions, including oral cancer (OC). However, most studies reporting an association between OC and periodontal disease have used different c…
View article: Cytotoxic and mutagenic capacity of TTO and terpinen-4-ol in oral squamous cell carcinoma
Cytotoxic and mutagenic capacity of TTO and terpinen-4-ol in oral squamous cell carcinoma Open
The essential oil of Melaleuca Alternifolia (tea tree oil - TTO) consists of about 100 components, and the highest concentration are terpinen-4-ol. Studies of their cytotoxic capacity have shown effect on malignant neoplastic lineages. The…
View article: Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review
Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review Open
Background: Periodontitis has been associated with several systemic diseases and medical conditions, including oral cancer (OC). However, most studies reporting an association between OC and periodontal disease have used different c…
View article: Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives
Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives Open
View article: Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis
Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis Open
View article: Lycopene Modulates Pathophysiological Processes of Non-Alcoholic Fatty Liver Disease in Obese Rats
Lycopene Modulates Pathophysiological Processes of Non-Alcoholic Fatty Liver Disease in Obese Rats Open
Background: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver de…
View article: ESTUDO COMPARATIVO DA ESTRUTURA DO FÍGADO ENTRE RATAS JOVENS, ADULTAS E IDOSAS
ESTUDO COMPARATIVO DA ESTRUTURA DO FÍGADO ENTRE RATAS JOVENS, ADULTAS E IDOSAS Open
View article: Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model Open
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the format…
View article: Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study
Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation—A histopathological study Open
Summary Hydroxymethylnitrofurazone ( NFOH ) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole ( BZN ) which has been used during short‐ and long‐…
View article: Sporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in mice
Sporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in mice Open
View article: In vitro and in vivo efficacy and toxicity of nonyl 3,4-dihydroxybenzoate, a potent compound against dermatophytes biofilms
In vitro and in vivo efficacy and toxicity of nonyl 3,4-dihydroxybenzoate, a potent compound against dermatophytes biofilms Open
View article: Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway
Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway Open
We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-…