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View article: Metabolomic profiles of depression in Parkinson’s disease patients
Metabolomic profiles of depression in Parkinson’s disease patients Open
Depression is a common non-motor symptom of Parkinson’s disease (PD), with poorly understood mechanisms. To explore whether there are dysregulated metabolic pathways among PD patients with depression, we analyzed serum samples of PD patien…
View article: Air toxics and late-life dementia and cognitive impairment in Mexican Americans
Air toxics and late-life dementia and cognitive impairment in Mexican Americans Open
Our findings indicate that air toxics are adversely associated with cognition in older Mexican Americans, providing critical evidence that traffic- and industry-related air toxics contribute to cognitive impairment. Future studies explorin…
View article: Investigating the Aliso Canyon gas blowout disaster and adverse birth outcomes: A quasiexperimental approach
Investigating the Aliso Canyon gas blowout disaster and adverse birth outcomes: A quasiexperimental approach Open
On 23 October 2015, operators at the Aliso Canyon Natural Gas Storage field in Northern Los Angeles reported an uncontrolled natural gas leak. The blowout persisted for 112 days, releasing ~109,000 metric tons of methane into the atmospher…
View article: Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study
Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study Open
Background Pregnancy complications have been associated with offspring autism spectrum disorders (ASD). There has also been increasing evidence for multigenerational risk factors of ASD. Methods In a multigenerational California birth coho…
View article: Identification of Pesticides Associated with an Increased Risk of Parkinson’s Disease using a Multi-Screen Approach
Identification of Pesticides Associated with an Increased Risk of Parkinson’s Disease using a Multi-Screen Approach Open
Parkinson’s Disease (PD) is a progressive neurodegenerative disease characterized by aggregation and transmission of alpha-synuclein (α-syn) protein and loss of dopaminergic neurons. The etiology of PD is multifactorial involving both gene…
View article: Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study
Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study Open
We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,6…
View article: Air Pollution and Autism Spectrum Disorder: Unveiling Multipollutant Risks and Sociodemographic Influences in California
Air Pollution and Autism Spectrum Disorder: Unveiling Multipollutant Risks and Sociodemographic Influences in California Open
Exposure to specific air pollutants during pregnancy and in the postnatal periods is associated with an increased risk of ASD, with sociodemographic differences potentially highlighting exposure hot spots and sources as well as subpopulati…
View article: Challenges in studying air pollution to neurodegenerative diseases
Challenges in studying air pollution to neurodegenerative diseases Open
Exposure to ambient air pollution is ubiquitous and unavoidable. While associations between air pollution and cardiometabolic diseases are well-established, its role in neurodegenerative diseases, such as Alzheimer's disease and related de…
View article: Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score
Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score Open
Importance Genetic and environmental factors are linked to Parkinson disease (PD), but the role of genetic susceptibility in the association between traffic-related air pollution (TRAP) and PD remains unclear. Objective To assess the gene-…
View article: The Pesticide Chlorpyrifos Increases the Risk of Parkinson’s Disease
The Pesticide Chlorpyrifos Increases the Risk of Parkinson’s Disease Open
Background and Purpose Pesticides have been associated with an increased risk of Parkinson’s disease (PD), but it is unclear which specific pesticides contribute to this association and whether it is causal. Since chlorpyrifos (CPF) exposu…
View article: The Cost of Adrenal Insufficiency in England—Analysis of NHS HES Data
The Cost of Adrenal Insufficiency in England—Analysis of NHS HES Data Open
Background Despite steroid replacement therapy, patients with adrenal insufficiency (AI) experience excessive infections and related hospital admissions. However, data examining the evolution of admissions, healthcare resources utilisation…
View article: Changes in traffic-related air pollution exposures and associations with adverse birth outcomes over 20 years in Texas
Changes in traffic-related air pollution exposures and associations with adverse birth outcomes over 20 years in Texas Open
Background Billions of dollars have been spent implementing regulations to reduce traffic-related air pollution (TRAP) from exhaust pipe emissions. However, few health studies have evaluated the change in TRAP emissions and associations wi…
View article: DNA methylation biomarkers for cumulative lead exposures and cognitive impairment
DNA methylation biomarkers for cumulative lead exposures and cognitive impairment Open
These findings strengthen the evidence that cumulative long-term lead exposure levels are associated with decreased cognitive function in the elderly, especially among women and carriers of one or two APOE4 alleles. These findings based on…
View article: The Role of Inflammation and Psycho-Behavioral Factors as Mediators Between Acculturation and Time to Incident Dementia Among Older Mexican Americans
The Role of Inflammation and Psycho-Behavioral Factors as Mediators Between Acculturation and Time to Incident Dementia Among Older Mexican Americans Open
Background: The mechanisms through which acculturation influences the onset of cognitive impairment and dementia are not well understood, especially among older Hispanics. Objective: To investigate whether inflammation and psycho-behaviora…
View article: Urinary polycyclic aromatic hydrocarbon metabolites and their association with oxidative stress among pregnant women in Los Angeles
Urinary polycyclic aromatic hydrocarbon metabolites and their association with oxidative stress among pregnant women in Los Angeles Open
Background Polycyclic aromatic hydrocarbons (PAHs) have been linked to adverse birth outcomes that have been reported to be induced by oxidative stress, but few epidemiological studies to date have evaluated associations between urinary PA…
View article: Preconception and first trimester exposure to pesticides and associations with stillbirth
Preconception and first trimester exposure to pesticides and associations with stillbirth Open
Associations of pesticide exposures during preconception with stillbirth have not been well explored. We linked Arizona pesticide use records with birth certificates from 2006 to 2020 and estimated associations of living within 500 m of an…
View article: Contributions of neighborhood physical and social environments to racial and ethnic disparities in birth outcomes in California: A mediation analysis
Contributions of neighborhood physical and social environments to racial and ethnic disparities in birth outcomes in California: A mediation analysis Open
Racially minoritized populations experience higher rates of adverse birth outcomes than White populations in the U.S. We estimated the mediating effect of neighborhood social and physical environments on disparities in adverse birth outcom…
View article: High traffic roads and adverse birth outcomes: comparing births upwind and downwind of the same road
High traffic roads and adverse birth outcomes: comparing births upwind and downwind of the same road Open
Traffic-related air pollution is a major concern for perinatal health. Determining causal associations, however, is difficult because high-traffic areas tend to correspond with lower socioeconomic neighborhoods and other environmental expo…