Roberto Romero
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View article: Risk factors for spontaneous preterm birth are mediated through changes in cervical length
Risk factors for spontaneous preterm birth are mediated through changes in cervical length Open
This study provides an account of the intermediary role of cervical dynamics in associations between known maternal risk factors and gestational age at delivery. Although these findings may not be generalizable to all populations, they hav…
View article: In Vitro Evaluation of Tooth Enamel Abrasion and Roughness Using Toothpaste with and Without Activated Charcoal: An SEM Analysis
In Vitro Evaluation of Tooth Enamel Abrasion and Roughness Using Toothpaste with and Without Activated Charcoal: An SEM Analysis Open
Background/Objectives: Dental enamel constitutes the first barrier of defense against external factors that constantly generate wear and damage. This study aimed to evaluate in vitro the abrasion and roughness of dental enamel using toothp…
View article: Amniotic Fluid PROK1 Profiling and Its Association with Infectious Preterm Birth
Amniotic Fluid PROK1 Profiling and Its Association with Infectious Preterm Birth Open
Prokineticin 1 (PROK1), known as EG-VEGF, is a key regulator of pregnancy, playing a crucial role from implantation to birth. Our studies have shown that circulating concentrations of PROK1 are highest during the first trimester and are el…
View article: The genetic architecture of cervical length is shared with spontaneous preterm birth risk
The genetic architecture of cervical length is shared with spontaneous preterm birth risk Open
These results suggest that a large proportion of genetic loci for preterm birth exert their influence through the process of cervical remodeling. Polygenic profiling of maternal genetic liability to cervical shortening could aid in the dev…
View article: Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics
Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics Open
Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models. Herein, we curated 1,842 public placental methylomes and…
View article: Molecular evidence in support of hematogenous dissemination of intraamniotic infection caused by <i>Listeria monocytogenes</i> in spontaneous preterm labor
Molecular evidence in support of hematogenous dissemination of intraamniotic infection caused by <i>Listeria monocytogenes</i> in spontaneous preterm labor Open
Objectives Intraamniotic infection is a major cause of preterm labor. While ascending infection from the urogenital tract is well recognized, hematogenous transmission in which pathogens travel from the maternal circulation to the intraamn…
View article: Benchmarking Large Language Models for Predictive Modeling in Biomedical Research With a Focus on Reproductive Health
Benchmarking Large Language Models for Predictive Modeling in Biomedical Research With a Focus on Reproductive Health Open
Generative AI, particularly large language models (LLMs), is increasingly being used in computational biology to support code generation for data analysis. In this study, we evaluated the ability of LLMs to generate functional R and Python…
View article: Neutrophil to Lymphocyte Ratio as a Biomarker for the Prediction of Cancer Outcomes and Immune-Related Adverse Events in a CTLA-4-Treated Population
Neutrophil to Lymphocyte Ratio as a Biomarker for the Prediction of Cancer Outcomes and Immune-Related Adverse Events in a CTLA-4-Treated Population Open
Background/Objectives: Immune-related adverse events (irAEs) triggered by immune checkpoint inhibitor therapy (ICI) have been paradoxically associated with both significant morbidity and improved cancer outcomes. While predictive markers f…
View article: Evaluation of Tooth Enamel Abrasion and Roughness Using Toothpastes with and Without Activated Charcoal: In Vitro Study and SEM Analysis
Evaluation of Tooth Enamel Abrasion and Roughness Using Toothpastes with and Without Activated Charcoal: In Vitro Study and SEM Analysis Open
Background/ObjectivesDental enamel constitutes the first barrier of defense against external factors that constantly generate wear and damage. The objective of the study was to evaluate the abrasion and roughness of tooth enamel using toot…
View article: The rapid diagnosis of intraamniotic infection with nanopore sequencing
The rapid diagnosis of intraamniotic infection with nanopore sequencing Open
The 16S nanopore sequencing has high diagnostic indices, predictive values, likelihood ratios, and accuracy in the diagnosis of intraamniotic infection.
View article: From Traditional to Cutting-Edge: A Review of Fetal Well-Being Assessment Techniques
From Traditional to Cutting-Edge: A Review of Fetal Well-Being Assessment Techniques Open
The birth of a new life, which should be a blessing to everyone, is regrettably not always the case. According to the latest data, the worldwide rate of stillbirths in 2022 stood at 13.9 stillbirths per 1,000 total births. This translates …
View article: Cultivation and molecular characterization of foley catheterized urine, clean catch urine, and vaginal swabs from pregnant women prior to delivery
Cultivation and molecular characterization of foley catheterized urine, clean catch urine, and vaginal swabs from pregnant women prior to delivery Open
The bladder and urine have historically been considered sterile, especially in the context of clinical assessment. Yet, enhanced culture techniques and advances in DNA sequencing surveys have revealed a low microbial biomass microbiota in …
View article: Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice
Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice Open
Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammatio…
View article: Molecular evidence that GBS early neonatal sepsis results from ascending infection: comparative hybrid genomics analyses show that microorganisms in the vaginal ecosystem, amniotic fluid, chorioamniotic membranes, and neonatal blood are the same
Molecular evidence that GBS early neonatal sepsis results from ascending infection: comparative hybrid genomics analyses show that microorganisms in the vaginal ecosystem, amniotic fluid, chorioamniotic membranes, and neonatal blood are the same Open
Objectives Streptococcus agalactiae , or Group B Streptococcus (GBS), is a leading cause of neonatal sepsis. Materno-fetal transmission of the microorganisms present in the lower genital tract/perineum is considered to be the most frequent…
View article: A Wireless and Wearable Multimodal Sensor to Non-Invasively Monitor Transabdominal Placental Oxygen Saturation and Maternal Physiological Signals
A Wireless and Wearable Multimodal Sensor to Non-Invasively Monitor Transabdominal Placental Oxygen Saturation and Maternal Physiological Signals Open
Poor placental development and placental defects can lead to adverse pregnancy outcomes such as pre-eclampsia, fetal growth restriction, and stillbirth. This study introduces two sensors, which use a near-infrared spectroscopy (NIRS) techn…
View article: Tackling the Giants: Applying Smart Labs Principles to Constant Air Volume Lab Buildings
Tackling the Giants: Applying Smart Labs Principles to Constant Air Volume Lab Buildings Open
Laboratories typically consume 3 to 10 times more energy than similarly sized commercial buildings, and as much as 50% of that energy is wasted by inefficient and poorly operating fume hoods and ventilation systems. One challenge faced by …
View article: 7065 Eradication Of Metastatic ER-Positive Breast, Ovarian, Endometrial And Lung Cancer In Mouse Xenografts And Patient Derived Organoids
7065 Eradication Of Metastatic ER-Positive Breast, Ovarian, Endometrial And Lung Cancer In Mouse Xenografts And Patient Derived Organoids Open
Disclosure: D.J. Shapiro: None. D. Duraki: None. S. Ghosh: None. J. Zhu: None. C. Mao: None. J. Kim: None. M. Jabeen: None. M.W. Boudreau: None. M.P. Mulligan: None. R. Romero: None. Y. Han: None. J. Zhang: None. E.R. Nelson: None. O. Olop…
View article: 7065 Eradication of Metastatic ER-positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids
7065 Eradication of Metastatic ER-positive Breast, Ovarian, Endometrial and Lung Cancer in Mouse Xenografts and Patient Derived Organoids Open
Disclosure: D.J. Shapiro: None. D. Duraki: None. S. Ghosh: None. J. Zhu: None. C. Mao: None. J. Kim: None. M. Jabeen: None. M.W. Boudreau: None. M.P. Mulligan: None. R. Romero: None. Y. Han: None. J. Zhang: None. E.R. Nelson: None. O. Olop…
View article: Proteomic Profiles of Maternal Plasma Extracellular Vesicles for Prediction of Preeclampsia
Proteomic Profiles of Maternal Plasma Extracellular Vesicles for Prediction of Preeclampsia Open
Problem Preeclampsia is a heterogeneous syndrome of diverse etiologies and molecular pathways leading to distinct clinical subtypes. Herein, we aimed to characterize the extracellular vesicle (EV)‐associated and soluble fractions of the ma…
View article: Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus Open
Background Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces fu…
View article: Quantitative cervicovaginal fluid fetal fibronectin: A liquid biopsy for intra‐amniotic inflammation
Quantitative cervicovaginal fluid fetal fibronectin: A liquid biopsy for intra‐amniotic inflammation Open
Introduction Intra‐amniotic inflammation is causally linked to spontaneous preterm labor. The gold standard for the diagnosis of intra‐amniotic inflammation is the determination of an amniotic fluid profile obtained from transabdominal amn…
View article: VMAP: Vaginal Microbiome Atlas during Pregnancy
VMAP: Vaginal Microbiome Atlas during Pregnancy Open
Objectives To enable interactive visualization of the vaginal microbiome across the pregnancy and facilitate discovery of novel insights and generation of new hypotheses. Material and Methods Vaginal Microbiome Atlas during Pregnancy (VMAP…
View article: The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study
The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study Open
Background: Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Most cases of preterm birth occur spontaneously and result from preterm labor with intact (spontaneous preterm labor [sPTL]) or ruptured (preterm…
View article: The Genetic Architecture of Cervical Length is Shared with Spontaneous Preterm Birth Risk
The Genetic Architecture of Cervical Length is Shared with Spontaneous Preterm Birth Risk Open
Study Question Is there a genetic contribution to the change in cervical length during pregnancy and, if so, how is this related to the known genetic contribution to pregnancy duration? Summary Answer Genomic analyses suggest that cervical…