Explanipedia

Refractory Systemic Sclerosis–Related Digital Ulcer Successfully Treated With Hyperbaric Oxygen Therapy: A Case Report and Literature Review Open

Huda Alfaris, Rita Katznelson, Sindhu R. Johnson · 2025

SLE classification criteria item relationships: implications on SLE as a disease entity Open

Martin Aringer, Franziska Szelinski, Thomas Dörner, Karen H. Costenbader, Sindhu R. Johnson · 2025

This comprehensive analysis of relationships between the domains and items of the EULAR/ACR SLE classification criteria underlines the relevance of the domain structure. Overall, the data are more compatible with chance distribution than w…

Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody–Positive Individuals Open

Carolina Muñoz‐Grajales, Carmen C. Ucciferri, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad , et al. · 2025

Objective The transition from asymptomatic antinuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of proinflammatory factors such as tumor necrosis factor α (TNFα). Her…

Alterations in Innate Immune Populations During Systemic Autoimmune Rheumatic Disease Development Open

Carmen C. Ucciferri, Carol Nassar, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad , et al. · 2025

Objectives Systemic autoimmune rheumatic diseases (SARD) are a group of chronic diseases characterized by the presence of antinuclear antibodies (ANAs).[1] However, ANAs cannot reliably be used as a diagnostic tool because a subset of heal…

Clinically Available Biomarkers Associated with Systemic Autoimmune Rheumatic Disease Progression in Anti-Nuclear Antibody Positive Individuals Open

Nazanin Soghrati, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla , et al. · 2025

Objectives The presence of Anti-Nuclear Antibodies (ANA) are a hallmark of Systemic Autoimmune Rheumatic Disease (SARD) and can be present years before clinical diagnosis. Although this suggests that ANAs could be used as potential biomark…

POS0557 Improving Systemic Sclerosis Quality of Care. An Interrupted Time Series Quality Improvement Study Open

Aos Aboabat, Samar Aboulenain, Hossein E. Jazayeri, Zareen Ahmad, M. Soowamber , et al. · 2025

POS1423 ALTERATIONS IN INNATE IMMUNE POPULATIONS DURING SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE DEVELOPMENT Open

Claudio Ucciferri, Carine M. Nassar, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad , et al. · 2025

POS1224 CONSENSUS-BASED GUIDANCE FOR GLUCOCORTICOID TAPERING IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS FROM A MODIFIED DELPHI CONSENSUS PROJECT Open

Edward M Vital, George Βertsias, Andrea Doria, Sindhu R. Johnson, Sarah Mackie , et al. · 2025

ALTERATIONS IN INNATE IMMUNE POPULATIONS DURING SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE DEVELOPMENT Open

Carmen C. Ucciferri, Carol Nassar, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad , et al. · 2025

O022 / #466 Topic: AS14 - Innate Immunity ABSTRACT CONCURRENT SESSION 03: INNATE AND ADAPTIVE IMMUNITY IN SLE 22-05-2025 1:40 PM - 2:40 PM Background/Purpose Systemic autoimmune rheumatic diseases (SARD) are a group of chronic diseases cha…

P147 Lupus damage index revision: item generation and reduction phase Open

Burak Kundakci, Megan R.W. Barber, Ann E. Clarke, Sindhu R. Johnson, Ian N Bruce · 2025

Background/Aims The Systemic Lupus International Collaborating Clinics (SLICC), the American College of Rheumatology (ACR) and the Lupus Foundation of America (LFA) collaboratively embarked on a project to develop a revised Systemic Lupus …

Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set Open

Wils Nielsen, Fadi Kharouf, Carolina Muñoz‐Grajales, Aarabi Thayaparan, Melanie Anderson , et al. · 2025

The 25 candidate domains cover the important aspects of SLE and the 4 core areas of disease impact according to OMERACT framework. The 25 candidate domains constitute a feasible and manageable number of domains to proceed with to the core …

Treatment Patterns and Outcomes of Scleroderma Renal Crisis in the International Scleroderma Renal Crisis Survey II – An Inception Cohort Study Open

Robert Chan, Melanie Baniña, Claudie Berger, Cybele Ghossein, Sabrina Hoa , et al. · 2025

Alcohol Consumption is Associated with Spinal Radiographic Progression in Axial Spondyloarthritis Open

Evelyne Gendron, Sameer Masood, Sindhu R. Johnson, Robert D. Inman, Nigil Haroon · 2025

Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants Open

Linda Kwakkenbos, Brooke Levis, Richard S. Henry, Gabrielle Virgili-Gervais, Marie‐Eve Carrier , et al. · 2024

Objectives The objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors. Methods Scleroderma Patient-cente…

Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the <span>European Alliance of Associations for Rheumatology</span>/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure Open

Sindhu R. Johnson, Hana Alahmari, Dennisse Bonilla, Zareen Ahmad, Arthur Bookman , et al. · 2024

Objective Our objective was to evaluate the development of a systemic autoimmune rheumatic disease (SARD) in undifferentiated and asymptomatic individuals with antinuclear antibodies (ANAs). We comparatively evaluated those who did and did…

Scleritis in Systemic Sclerosis Treated With Infliximab Biosimilar Open

Huda Alfaris, Marissa Sit, Sindhu R. Johnson · 2024

An 84-year-old woman diagnosed in 2002 with limited cutaneous systemic sclerosis (SSc) that is characterized by sclerodactyly, telangiectasia, Raynaud phenomenon, gastroesophageal reflux, and antinuclear antibodies, but negative for ScL70 …

Assessing Patient Values and Preferences to Inform the 2023 American College of Rheumatology/American College of Chest Physicians Interstitial Lung Disease Guidelines Open

Reza Mirza, Marcy B. Bolster, Sindhu R. Johnson, Aberdeen Allen, Elana J. Bernstein , et al. · 2024

Objective Patient engagement is critical to clinical practice guideline (CPG) development. This work presents our approach to ascertaining patients’ values and preferences to inform the American College of Rheumatology guidelines for scree…

Outcome clusters and their stability over 1 year in patients with SLE: self-reported and performance-based cognitive function, disease activity, mood and health-related quality of life Open

Ambika Gupta, Sindhu R. Johnson, Michelle Barraclough, Jiandong Su, Kathleen Bingham , et al. · 2024

Objective To determine if self-reported fatigue, anxiety, depression, cognitive difficulties, health-related quality of life, disease activity scores and neuropsychological battery (NB) cluster into distinct groups in patients with SLE bas…

Experiences of telehealth during and after the COVID-19 pandemic and preferences for future care of people with systemic sclerosis: a cross-sectional study Open

Elsa‐Lynn Nassar, Gabrielle Virgili-Gervais, Marie‐Eve Carrier, Linda Kwakkenbos, Richard S. Henry , et al. · 2024

Effects of Radiotherapy for Malignancy in Systemic Sclerosis: A Systematic Review Open

Aos Aboabat, Mohammed Aldohan, Patrick Cheung, Ani Orchanian‐Cheff, Sindhu R. Johnson · 2024

Objective Concerns regarding offering radiotherapy to patients with systemic sclerosis (SSc) stem from the potential worsening of SSc manifestations and radiotherapy toxicity. We conducted a systematic review to evaluate the effects of rad…

Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study Open

Tiffany Dal Santo, Danielle B. Rice, Marie‐Eve Carrier, Gabrielle Virgili-Gervais, Brooke Levis , et al. · 2024

Objectives To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors. Methods Scleroderma Patient-centered Intervention Network Cohort participants completed …

Biomarker analysis from the phase 2b randomized placebo-controlled trial of riociguat in early diffuse cutaneous systemic sclerosis Open

Dinesh Khanna, Frank Kramer, Josef Höfler, Mercedeh Ghadessi, Peter Sandner , et al. · 2024

Objective To examine disease and target engagement biomarkers in the RISE-SSc trial of riociguat in early diffuse cutaneous systemic sclerosis and their potential to predict the response to treatment. Methods Patients were randomized to ri…

Defining the key clinician skills and attributes for competency in managing patients with osteoporosis and fragility fractures Open

Lesley E. Jackson, Kenneth G. Saag, Sindhu R. Johnson, Maria I. Danila · 2024

Osteoporosis and fragility fractures are managed by clinicians across many medical specialties. The key competencies of clinicians delivering bone health care have not been systematically established. We aimed to develop a decision rule to…

The Efficacy and Tolerability of Prostaglandin Analogues in Treating Systemic Sclerosis‐Associated Raynaud Phenomenon: A Systematic Review and Meta‐Analysis Open

Hana Alahmari, Hila Jazayeri, Sindhu R. Johnson · 2024

Background: Systemic sclerosis‐associated Raynaud phenomenon (SSc‐RP) confers poor outcomes, including ulceration, gangrene, autoamputation, and hand disability. Prostaglandin analogues (PG) are a group of prostacyclin‐derived drugs with p…

Patterns of patient-reported symptoms and association with sociodemographic and systemic sclerosis disease characteristics: a scleroderma Patient-centered Intervention Network (SPIN) Cohort cross-sectional study Open

Robyn K. Wojeck, Mitchell R. Knisely, Donald E. Bailey, Tamara J. Somers, Linda Kwakkenbos , et al. · 2023

Effects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease Open

Yannick Allanore, Dinesh Khanna, Vanessa Smith, Martin Aringer, Anna‐Maria Hoffmann‐Vold , et al. · 2023

Objectives To investigate the course of interstitial lung disease (ILD) and the effects of nintedanib in patients with limited cutaneous systemic sclerosis (lcSSc). Methods In the SENSCIS trial, patients with SSc-ILD were randomized to rec…

POS1488 LUPUS DAMAGE INDEX REVISION – INITIAL ITEM REDUCTION PHASE Open

Burak Kundakci, Megan R.W. Barber, Ann E. Clarke, Sindhu R. Johnson, Ian N Bruce · 2023

POS0338 DEVELOPMENT AND VALIDATION OF RANKED COMPOSITE IMPORTANT DIFFERENCE (RCID) SCORE IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS Open

F. Del Galdo, L. A. Bissell, S. Huang, Peter Hansen, Sindhu R. Johnson , et al. · 2023

POS0393 DEFINING THE KEY ATTRIBUTES OF A CLINICIAN WITH COMPETENCE IN BONE HEALTH MANAGEMENT Open

Lesley E. Jackson, Sindhu R. Johnson, Ellen McNeeley, Kenneth G. Saag, M. Danila · 2023

Background Osteoporosis and fragility fractures are managed by clinicians across a variety of specialties and there is no specific certification in osteoporosis diagnosis and management. These clinicians are an integral part of interventio…

State-of-the-art evidence in the treatment of systemic sclerosis Open

Janet Pope, Christopher P. Denton, Sindhu R. Johnson, Andreu Fernández‐Codina, Marie Hudson , et al. · 2023

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