Bing Bai
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View article: Treatment patterns and survival outcomes after immunotherapy failure in patients with NK/T cell lymphoma: A multicenter retrospective study
Treatment patterns and survival outcomes after immunotherapy failure in patients with NK/T cell lymphoma: A multicenter retrospective study Open
Background: Natural killer/T cell lymphoma (NKTCL) is a distinct subtype of non-Hodgkin lymphoma, with a higher incidence in East Asia and South America. Immunotherapy-based regimens have been widely used in NKTCL as both first-line and sa…
View article: Combination anti-PD1 antibody and rituximab followed by R-CHOP for newly diagnosed DLBCL in elderly patients: Updated results of the phase II TREND trial
Combination anti-PD1 antibody and rituximab followed by R-CHOP for newly diagnosed DLBCL in elderly patients: Updated results of the phase II TREND trial Open
Background: Patients with diffuse large B-cell lymphoma (DLBCL) in the elderly face challenges in treatment due to comorbidities and tolerance of chemotherapy. Age >60 years is an unfavorable risk factor of outcome in DLBCL in the Inter…
View article: Production of human cathepsins using <scp>Expi293™</scp> mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening
Production of human cathepsins using <span>Expi293™</span> mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening Open
Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of ant…
View article: Characteristics of Japanese encephalitis virus infection in NCG-hSTAT2+/+ mice: a novel model for studying neurological symptoms and immune response
Characteristics of Japanese encephalitis virus infection in NCG-hSTAT2+/+ mice: a novel model for studying neurological symptoms and immune response Open
Japanese encephalitis virus (JEV), a leading cause of viral encephalitis in Asia and the Western Pacific, is regulated by type I interferon (IFN) signaling pathway, in which STAT2 is critical. However, the exact role of STAT2 in JEV-mediat…
View article: Hepatic Follicular Dendritic Cell Sarcoma with a History of Cervical Cancer: A Rare Case Report of Multiple Primary Malignant Neoplasms
Hepatic Follicular Dendritic Cell Sarcoma with a History of Cervical Cancer: A Rare Case Report of Multiple Primary Malignant Neoplasms Open
The follicular dendritic cell sarcoma (FDCS) is a rare entity, accounting for only 0.4% of all soft tissue sarcomas. Hepatic FDCS, which represents approximately 30% of extranodal FDCS cases, has been reported in only 30 cases in the Engli…
View article: Identification of potential anti aging drugs and targets in chronic kidney disease
Identification of potential anti aging drugs and targets in chronic kidney disease Open
Chronic kidney disease (CKD) is highly prevalent, incurable, and lacks effective treatments. Aging is closely linked to various kidney diseases. In this study, we combined CKD and aging using bioinformatics approaches to identify potential…
View article: Endoscopic removal of a large gastric trichobezoar using a snare modified from a lithotripter to facilitate argon plasma coagulation
Endoscopic removal of a large gastric trichobezoar using a snare modified from a lithotripter to facilitate argon plasma coagulation Open
View article: Simultaneous Determination of Six Acidic Herbicides and Metabolites in Plant Origin Matrices by QuEChERS-UPLC-MS/MS
Simultaneous Determination of Six Acidic Herbicides and Metabolites in Plant Origin Matrices by QuEChERS-UPLC-MS/MS Open
This study presents a method for the simultaneous determination of six acidic herbicides and their metabolites in various matrices, including fruits, vegetables, grains, and edible oils. The method employs acidified acetonitrile extraction…
View article: The Maturity Phase is Crucial for the Removal of Antibiotic Resistance Genes During Composting: Novel Insights into The Dom-Microbial Symbiosis System
The Maturity Phase is Crucial for the Removal of Antibiotic Resistance Genes During Composting: Novel Insights into The Dom-Microbial Symbiosis System Open
View article: Discovery of Novel Pyrido[2,3‐<i>b</i>]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition
Discovery of Novel Pyrido[2,3‐<i>b</i>]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition Open
The development of non‐nucleoside inhibitors targeting human cytomegalovirus (HCMV) polymerase presents a promising approach for enhancing therapeutic treatment for patients with sustained HCMV viremia. A series of non‐nucleoside HCMV DNA …
View article: Anion-driven enabled functional nanomaterials from metal and metal oxide nanoparticles
Anion-driven enabled functional nanomaterials from metal and metal oxide nanoparticles Open
View article: Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study Open
View article: Dynamics of The Γδtcr Repertoires During The Dedifferentiation Process and Pilot Implications for Immunotherapy of Thyroid Cancer
Dynamics of The Γδtcr Repertoires During The Dedifferentiation Process and Pilot Implications for Immunotherapy of Thyroid Cancer Open
γδ T cells are evolutionarily conserved T lymphocytes that manifest unique antitumor efficacy independent of tumor mutation burden (TMB) and conventional human leukocyte antigen (HLA) recognition. However, the dynamic changes in their T ce…
View article: Enhancing Long-Distance Optical Link Performance with Multi-Stage Amplification and Systematic Design
Enhancing Long-Distance Optical Link Performance with Multi-Stage Amplification and Systematic Design Open
View article: Construction of Polyaniline Three-Dimensional Nano-Networks on Carbon Cloth Fibers for Supercapacitors
Construction of Polyaniline Three-Dimensional Nano-Networks on Carbon Cloth Fibers for Supercapacitors Open
View article: The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism Open
This study explores the relationship between structural alterations of nirmatrelvir, such as homologation and deuteration, and metabolic stability of newly synthesized derivatives. We developed a reliable synthetic protocol toward dideuter…
View article: PB1733: LONG-TERM FOLLOW-UP FOR PATIENTS WITH T CELL LYMPHOBLASTIC LYMPHOMA/ ACUTE LYMPHOBLASTIC LEUKEMIA WHO RECEIVED MODIFIED BFM PROTOCOLS
PB1733: LONG-TERM FOLLOW-UP FOR PATIENTS WITH T CELL LYMPHOBLASTIC LYMPHOMA/ ACUTE LYMPHOBLASTIC LEUKEMIA WHO RECEIVED MODIFIED BFM PROTOCOLS Open
Topic: 2. Acute lymphoblastic leukemia - Clinical Background: Although the prognosis of lymphoblastic lymphoma (LBL) has significantly improved with the application of intensive acute lymphoblastic leukemia (ALL)-type chemotherapy regimens…
View article: Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential Open
View article: SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals Open
The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in Mpro may…
View article: SARS-CoV-2 M<sup>pro</sup>protease variants of concern display altered viral and host target processing but retain potency towards antivirals
SARS-CoV-2 M<sup>pro</sup>protease variants of concern display altered viral and host target processing but retain potency towards antivirals Open
Main protease of SARS-CoV-2 (M pro ) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in M pro may alter structural and f…
View article: Correction: Atomically flat semiconductor nanoplatelets for light-emitting applications
Correction: Atomically flat semiconductor nanoplatelets for light-emitting applications Open
Correction for ‘Atomically flat semiconductor nanoplatelets for light-emitting applications’ by Bing Bai et al. , Chem. Soc. Rev. , 2023, 52 , 318–360, https://doi.org/10.1039/D2CS00130F.
View article: Inhibition of the HERG Potassium Ion Channel by Different Non-Nucleoside Human Cytomegalovirus Polymerase Antiviral Templates and the Exploration of Variations of a Pyrroloquinoline Series to Reduce Cardiotoxicity Potential
Inhibition of the HERG Potassium Ion Channel by Different Non-Nucleoside Human Cytomegalovirus Polymerase Antiviral Templates and the Exploration of Variations of a Pyrroloquinoline Series to Reduce Cardiotoxicity Potential Open
View article: Effect of gasless endoscopic thyroidectomy through an axillary approach on the recurrent laryngeal nerve injury in patients with thyroid cancer
Effect of gasless endoscopic thyroidectomy through an axillary approach on the recurrent laryngeal nerve injury in patients with thyroid cancer Open
Objective: To observe the effect of gasless endoscopic thyroidectomy through an axillary approach (GETAN) on the recurrent laryngeal nerve in patients with thyroid cancer. Methods: One hundred and ten patients with thyroid cancer admitted …
View article: Effect of Hospital-Family Rehabilitation Intervention on Walking Function and Lower Limb Surface Electromyography in Children with Cerebral Palsy
Effect of Hospital-Family Rehabilitation Intervention on Walking Function and Lower Limb Surface Electromyography in Children with Cerebral Palsy Open
Objective. To explore the effect of hospital-family rehabilitation intervention on walking function and lower limb surface electromyography in children with cerebral palsy (CP). Methods. About 100 children with CP treated in our hospital f…
View article: Influence of Wallach’s Rule on Chiral AIE Systems and Its Application in Cryptographic Information Storage
Influence of Wallach’s Rule on Chiral AIE Systems and Its Application in Cryptographic Information Storage Open
Open AccessCCS ChemistryCOMMUNICATION7 Dec 2022Influence of Wallach's Rule on Chiral AIE Systems and Its Application in Cryptographic Information Storage Qiu Chen Peng, Xi Ming Luo, Yu Jing Qin, Ting Wang, Bing Bai, Xi Long Wei, Kai Li and…
View article: Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii
Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii Open
This is the accepted manuscript version of the work published in its final form as Shen, K., Bai, B., Liu, Y., & Lowary, T. L. (2021). Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobact…
View article: Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability Open
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this …
View article: Chronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China
Chronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China Open
Background Chinese population has a high prevalence of chronic hepatitis B virus (HBV) infection, the impact of which on pregnancy outcome remains controversial. A single-center retrospective cohort study was performed in Kunming, a multi-…
View article: Linezolid Resistance in Enterococcus faecalis Associated With Urinary Tract Infections of Patients in a Tertiary Hospitals in China: Resistance Mechanisms, Virulence, and Risk Factors
Linezolid Resistance in Enterococcus faecalis Associated With Urinary Tract Infections of Patients in a Tertiary Hospitals in China: Resistance Mechanisms, Virulence, and Risk Factors Open
Background: Enterococcus faecalis has been commonly considered as one of the major pathogens of the urinary tract infection (UTI) in human host worldwide, whereas the molecular characteristics of E. faecalis clinical isolates from the pati…
View article: Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors Open
This article describes peptidomimetic SARS-CoV-2 3CL pro inhibitors with a nitrile warhead with in vitro antiviral inhibition. Superior selectivity was observed for the nitrile warhead compared to the aldehyde against 3 human cathepsins (B…