Fernando C. Fervenza
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View article: Mass Spectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis
Mass Spectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis Open
View article: #1075 Cancer incidence and risk factors in PLA2R-associated membranous nephropathy
#1075 Cancer incidence and risk factors in PLA2R-associated membranous nephropathy Open
Background and Aims Malignancy is commonly seen in patients with membranous Nephropathy (MN) with a prevalence up to 22%. M-type phospholipase A2 receptor (PLA2R) antigen and its associated antibody account for up to 80% of the cases but i…
View article: Antiproteinuric effect of SGLT2 inhibitors in non-diabetic glomerulopathies is dependent on body mass index
Antiproteinuric effect of SGLT2 inhibitors in non-diabetic glomerulopathies is dependent on body mass index Open
Background Sodium–glucose co-transporter 2 inhibitors (SGLT2is) are emerging as an essential part of the standard of care for proteinuria in patients with chronic kidney disease. To date, no study has specifically evaluated the effects of …
View article: Acute Interstitial Nephritis Induced by Monoclonal Antibodies Targeting Calcitonin Gene-Related Peptide (CGRP)—Unveiling a New Association: A Case Report
Acute Interstitial Nephritis Induced by Monoclonal Antibodies Targeting Calcitonin Gene-Related Peptide (CGRP)—Unveiling a New Association: A Case Report Open
View article: Monoclonal Gammopathy in ANCA-Negative Pauci-immune Crescentic Glomerulonephritis: Is There an Association?
Monoclonal Gammopathy in ANCA-Negative Pauci-immune Crescentic Glomerulonephritis: Is There an Association? Open
Background: In a small subset of patients with pauci-immune crescentic glomerulonephritis (PICGN), antinuclear cytoplasmic antibodies (ANCA) are not identified, and patients are referred to as having ‘ANCA-negative’ vasculitis. The cause o…
View article: Laser Microdissection and Mass Spectrometry Reveals Diverse Membranous Nephropathy Antigens
Laser Microdissection and Mass Spectrometry Reveals Diverse Membranous Nephropathy Antigens Open
View article: Clinicopathological Characteristics and Long-Term Kidney Outcomes in Biopsy-Proven Renal Sarcoidosis
Clinicopathological Characteristics and Long-Term Kidney Outcomes in Biopsy-Proven Renal Sarcoidosis Open
Key Points Preexisting CKD, elevated serum creatinine, and severe interstitial fibrosis and tubular atrophy were linked to poor renal prognosis in renal sarcoidosis. Steroid therapy was strongly associated with renal recovery and improved …
View article: Long-term Outcome of Adult Patients With Membranous Nephropathy Treated With Rituximab
Long-term Outcome of Adult Patients With Membranous Nephropathy Treated With Rituximab Open
RTX treatment is associated with excellent long-term renal survival that compares favorably with historical survival rates using the cyclic corticosteroids/cyclophosphamide regimen.
View article: FOCAL, DIFFUSE, AND MEMBRANOUS LESIONS IN LUPUS NEPHRITIS: PROGNOSTIC IMPLICATIONS FOR RENAL OUTCOMES
FOCAL, DIFFUSE, AND MEMBRANOUS LESIONS IN LUPUS NEPHRITIS: PROGNOSTIC IMPLICATIONS FOR RENAL OUTCOMES Open
O038 / #692 Topic: AS15 - Lupus Nephritis-Clinical ABSTRACT CONCURRENT SESSION 06: LUPUS NEPHRITIS – CLINICAL OUTCOMES, PREDICTION AND THERAPY 23-05-2025 1:40 PM - 2:40 PM Background/Purpose Lupus nephritis (LN) is major cause of morbidity…
View article: PREDICTIVE VALUE OF CHRONIC HISTOLOGIC CHANGES IN LUPUS NEPHRITIS
PREDICTIVE VALUE OF CHRONIC HISTOLOGIC CHANGES IN LUPUS NEPHRITIS Open
O041 / #709 Topic: AS15 - Lupus Nephritis-Clinical ABSTRACT CONCURRENT SESSION 06: LUPUS NEPHRITIS – CLINICAL OUTCOMES, PREDICTION AND THERAPY 23-05-2025 1:40 PM - 2:40 PM Background/Purpose The Mayo Clinic Chronicity Score (MCCS) is a too…
View article: The importance of identifying new and putative target antigens associated with membranous nephropathy: evidence from a Sardinian cohort
The importance of identifying new and putative target antigens associated with membranous nephropathy: evidence from a Sardinian cohort Open
Background Membranous nephropathy (MN) is a leading cause of nephrotic syndrome (NS). Since the identification of anti–phospholipase A2 receptor (anti-PLA2R) antibodies in 2009, the use of laser microdissection and tandem mass spectrometry…
View article: The Clinicopathologic Characteristics of Recurrent Lupus Nephritis Post-Transplant Using Surveillance and Indication Biopsies
The Clinicopathologic Characteristics of Recurrent Lupus Nephritis Post-Transplant Using Surveillance and Indication Biopsies Open
View article: High Temperature Requirement Protein A1–Positive Membranous Nephropathy in a Patient With Chronic Lymphocytic Leukemia
High Temperature Requirement Protein A1–Positive Membranous Nephropathy in a Patient With Chronic Lymphocytic Leukemia Open
View article: “Normal” Glomerular Score Correlates With Outcomes in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis With Glomerulonephritis
“Normal” Glomerular Score Correlates With Outcomes in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis With Glomerulonephritis Open
View article: Lupus nephritis: redefining the treatment goals
Lupus nephritis: redefining the treatment goals Open
The course of proliferative lupus nephritis is characterized by flares of activity alternating with periods of quiescence against a background of chronic immune dysregulation. An accurate assessment of disease activity is of unassailable i…
View article: Hydroxychloroquine for all patients with lupus nephritis?: no
Hydroxychloroquine for all patients with lupus nephritis?: no Open
View article: Antimalarials in Lupus Nephritis
Antimalarials in Lupus Nephritis Open
SLE is a chronic multisystem autoimmune disease that affects the kidneys in approximately 50% of patients, with the prevalence rising to as high as 70% in certain populations, such as African American and Asian people. Antimalarials—and pa…
View article: Why laser microdissection and mass spectrometry is the method of choice for detection of membranous nephropathy antigens
Why laser microdissection and mass spectrometry is the method of choice for detection of membranous nephropathy antigens Open
View article: Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis With Diffuse Alveolar Hemorrhage With Avacopan
Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis With Diffuse Alveolar Hemorrhage With Avacopan Open
Objective Avacopan, an activated complement factor 5 receptor antagonist, has been approved as adjunct therapy for severe active antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Current evidence supports the management of A…
View article: Diagnostic yield of exome and genome sequencing after non-diagnostic multi-gene panels in patients with single-system diseases
Diagnostic yield of exome and genome sequencing after non-diagnostic multi-gene panels in patients with single-system diseases Open
Background Though next-generation sequencing (NGS) tests like exome sequencing (ES), genome sequencing (GS), and panels derived from exome and genome data (EGBP) are effective for rare diseases, the ideal diagnostic approach is debated. Li…
View article: Correction: Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)
Correction: Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD) Open
View article: Rituximab or cyclosporine A for the treatment of membranous nephropathy: economic evaluation of the MENTOR trial
Rituximab or cyclosporine A for the treatment of membranous nephropathy: economic evaluation of the MENTOR trial Open
Background and hypothesis The MENTOR trial (MEmbranous Nephropathy Trial Of Rituximab) showed that rituximab was noninferior to cyclosporine in inducing complete or partial remission of proteinuria and was superior in maintaining proteinur…
View article: WCN24-391 Predictive Factors of Renal Recovery and Progression to End-Stage Kidney Disease in Patients with ANCA-Associated Vasculitis with Severe Kidney Disease
WCN24-391 Predictive Factors of Renal Recovery and Progression to End-Stage Kidney Disease in Patients with ANCA-Associated Vasculitis with Severe Kidney Disease Open
A significant number of patients with anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) with glomerulonephritis (AAV-GN) still progress to end-stage kidney disease (ESKD, eGFR<15mL/min/1.73m2) despite advances in re…
View article: WCN24-389 Impact of Sex in Clinical Presentation and Outcomes of Patients with ANCAAssociated Vasculitis with Severe Kidney Disease
WCN24-389 Impact of Sex in Clinical Presentation and Outcomes of Patients with ANCAAssociated Vasculitis with Severe Kidney Disease Open
The impact of sex in the clinical presentation and outcomes of patients with anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) with glomerulonephritis (AAV-GN) has not been studied, particularly in patients with sev…
View article: WCN24-390 Combined Activity, Recovery, and Chronicity Kidney Biopsy Grading for Prognostic Assessment in ANCA-associated Vasculitis with Glomerulonephritis (AAV-GN)
WCN24-390 Combined Activity, Recovery, and Chronicity Kidney Biopsy Grading for Prognostic Assessment in ANCA-associated Vasculitis with Glomerulonephritis (AAV-GN) Open
Previous studies have shown that chronic changes on kidney biopsy are useful for stratifying the risk of kidney failure in patients with AAV-GN. We aimed to evaluate the impact of inflammatory activity for the prediction of renal outcomes.
View article: Predictive Factors of Renal Recovery and Progression to End-Stage Kidney Disease in Patients With Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis With Severe Kidney Disease
Predictive Factors of Renal Recovery and Progression to End-Stage Kidney Disease in Patients With Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis With Severe Kidney Disease Open
View article: Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy
Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy Open
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which are characterized by bright glomerula…
View article: O40 Impact of glucocorticoid dose on complete response, serious infections, and mortality during the initial therapy of lupus nephritis: a systematic review and meta-analysis of the standard of care arms of randomized controlled trials
O40 Impact of glucocorticoid dose on complete response, serious infections, and mortality during the initial therapy of lupus nephritis: a systematic review and meta-analysis of the standard of care arms of randomized controlled trials Open
Objective The recent EULAR SLE guidelines recommend the use of reduced GC regimens (0.3–0.5 mg/kg) in the treatment of LN. However, as they acknowledged, this is not evidence-based. Our objective was to evaluate the effect of different GC …
View article: Longitudinal analysis of blood pressure and lipids in childhood nephrotic syndrome
Longitudinal analysis of blood pressure and lipids in childhood nephrotic syndrome Open
View article: Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis
Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis Open
Background Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephrit…