Rakesh Sehgal
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View article: Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies
Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies Open
Leishmaniasis remains a significant global health challenge, with over a billion people at risk of infection and limited effective treatment options due to escalating drug resistance. This review explores the underlying mechanisms of drug …
View article: Enterobius vermicularis infection in congenital anorectal malformation
Enterobius vermicularis infection in congenital anorectal malformation Open
Introduction: Enterobius vermicularis (pinworm) infections are prevalent worldwide, particularly among children, and are sometimes associated with surgical conditions such as appendicitis. We present a case of pinworm infection in a child …
View article: Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess
Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess Open
The role of TLRs in association with ALA might provide insights into new therapeutic strategies.
View article: Possibility of re-purposing antifungal drugs posaconazole & isavuconazole against promastigote form of Leishmania major
Possibility of re-purposing antifungal drugs posaconazole & isavuconazole against promastigote form of Leishmania major Open
Background & objectives The emergence of drug resistance in leishmaniasis has remained a concern. Even new drugs have been found to be less effective within a few years of their use. Coupled with their related side effects and cost-effecti…
View article: Metallic nanoparticles in malaria treatment: advances in therapeutics, diagnostics, and future prospects
Metallic nanoparticles in malaria treatment: advances in therapeutics, diagnostics, and future prospects Open
Malaria remains one of the causes of extreme mortality in southern Africa and Southeast Asia. Despite extreme efforts to control and eliminate malaria, the appearance of drug-resistant parasites and their spread is a major concern. In this…
View article: ANTI-PLASMODIAL EFFECT OF NICOTINAMIDE- VITAMIN B3 AGAINST CHLOROQUINE RESISTANT MALARIA IN AN IN VIVO MODEL
ANTI-PLASMODIAL EFFECT OF NICOTINAMIDE- VITAMIN B3 AGAINST CHLOROQUINE RESISTANT MALARIA IN AN IN VIVO MODEL Open
Nicotinamide (NICO), an amide derivative of nicotinic acid, used in high doses for four decades, has shown antimicrobial and potential anti-malarial activity in vitro. However, its antiplasmodial effects in drug-resistant in vivo models we…
View article: Characterization of Antimicrobial Resistance Mechanisms and Virulence Determinants in Colistin- and Carbapenem-Resistant Pseudomonas aeruginosa
Characterization of Antimicrobial Resistance Mechanisms and Virulence Determinants in Colistin- and Carbapenem-Resistant Pseudomonas aeruginosa Open
Antibiotics like colistin can save patients infected with carbapenem-resistant Pseudomonas aeruginosa. However, patients can succumb to such infections even if they undergo colistin therapy. This prompted us to investigate the probable ant…
View article: Free-living amoebic encephalitis – Case series
Free-living amoebic encephalitis – Case series Open
Introduction: Free-living amoeba is ubiquitous in fresh water, mud, and moist soil; although seldom pathogenic to humans, Naegleria fowleri , Acanthamoeba spp., and Balamuthia spp. are known to cause infections of the central nervous syste…
View article: Synthesis and characterization of silver nanoparticle conjugated-chalcones and their evaluation for antimalarial, cytotoxicity and haemolytic potential at in vitro level
Synthesis and characterization of silver nanoparticle conjugated-chalcones and their evaluation for antimalarial, cytotoxicity and haemolytic potential at in vitro level Open
Silver nanoparticles (AgNPs) have shown a wide range of antimicrobial activities over the last 2 decades, but little is known about their antimalarial activity. Therefore, in the present study, AgNPs were surface functionalized by chalcone…
View article: Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study
Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study Open
Objective: We aimed to assess risk of COVID-19 infection & seroprotection status in healthcare workers (HCWs) in both hospital and community settings following an intensive vaccination drive in India. Setting: Tertiary Care Hospital Method…
View article: Updates in molecules associated with pathogenesis of amoebiasis: A mini review
Updates in molecules associated with pathogenesis of amoebiasis: A mini review Open
Amoebiasis caused due to the protozoan parasite Entamoeba histolytica has been ranked as the third major reason of mortality after Malaria and Schistosomiasis. The pathogen adversely impacts the health of the children and hinders their dev…
View article: Real‐time loop‐mediated isothermal amplification (real‐time LAMP) assay for rapid diagnosis of amoebic liver abscess
Real‐time loop‐mediated isothermal amplification (real‐time LAMP) assay for rapid diagnosis of amoebic liver abscess Open
Among the parasitic diseases, amoebic liver abscess (ALA) ranks second to malaria in terms of mortality. Due to the poor sensitivity of conventional diagnostic methods, there is a need for the development of effective and rapid diagnostic …
View article: Comparison of B1 and RE 529 gene targets by real time PCR and LAMP assay for diagnosis of toxoplasmosis in pregnant females
Comparison of B1 and RE 529 gene targets by real time PCR and LAMP assay for diagnosis of toxoplasmosis in pregnant females Open
Molecular methods were more sensitive than serological tests to diagnose congenital toxoplasmosis in antenatal females. Few seronegative patients were reported positive using molecular methods. In addition, LAMP targeting the RE-529 gene i…
View article: Unraveling the Interplay of Parasitaemia, Cytokines, and Pregnancy Outcomes in Plasmodium bergheiInfection: Insights from a Murine Model
Unraveling the Interplay of Parasitaemia, Cytokines, and Pregnancy Outcomes in Plasmodium bergheiInfection: Insights from a Murine Model Open
Malaria infection during pregnancy presents notable risks to both maternal and fetal health. Present study examines the impact of Plasmodium berghei NK-65 strain infection during different stages of pregnancy in mice. The study categorized…
View article: Low Prevalence of Soil-Transmitted Helminth Infections among Children in the States of Chhattisgarh and Himachal Pradesh, India, 2018
Low Prevalence of Soil-Transmitted Helminth Infections among Children in the States of Chhattisgarh and Himachal Pradesh, India, 2018 Open
Large-scale impact assessments of soil-transmitted helminth (STH) programs are essential for determining the frequency of mass drug administration (MDA). In baseline surveys, the prevalence of STHs in the Indian States of Chhattisgarh and …
View article: Comparative efficacy of natural aquatic predators for biological control of mosquito larvae: A neglected tool for vector control
Comparative efficacy of natural aquatic predators for biological control of mosquito larvae: A neglected tool for vector control Open
Mosquitoes are a dominant fraction of dipteran fauna, occupying a variety of niches. The most common method deployed for their control is the use of insecticides. Throughout their life cycle they are exposed to a wide range of predators in…
View article: Sub-Genotyping of Acanthamoeba T4 Complex: Experience from North India
Sub-Genotyping of Acanthamoeba T4 Complex: Experience from North India Open
The Acanthamoeba genus comprises the free-living amoebae that are ubiquitously present as opportunistic pathogens. They cause serious human diseases—for instance, Acanthamoeba keratitis (AK), granulomatous amoebic encephalitis (GAE), cutan…
View article: Hydro-Alcoholic Leaf Extract and Fractions of <i>Codiaeum variegatum</i> (var. Mollucanum) Exhibited an Improved Anti-Amoebic and Moderate Anti-Oxidant Potential
Hydro-Alcoholic Leaf Extract and Fractions of <i>Codiaeum variegatum</i> (var. Mollucanum) Exhibited an Improved Anti-Amoebic and Moderate Anti-Oxidant Potential Open
Amoebiasis, classified as the third intestinal parasitic infection, represents a public health problem in low-income countries where hygiene and sanitation conditions are poor. With the resurgence of resistant pathogenic strains as well as…