Jocelyn R. Setter
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View article: Data from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Data from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody–drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy …
View article: Data from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Data from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody–drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy …
View article: Supplementary Figure S1. Plasma stability from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Supplementary Figure S1. Plasma stability from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Plasma stability of quaternary ammonium linker in rodent plasma.
View article: Chemistry Experimental from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Chemistry Experimental from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Experimental details for the chemical synthesis of the drug-linkers.
View article: Supplementary Figure S2. ADC PK profiles from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Supplementary Figure S2. ADC PK profiles from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Pharmacokinetic profile of clearance for three ADCs.
View article: Supplementary Figure S1. Plasma stability from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Supplementary Figure S1. Plasma stability from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Plasma stability of quaternary ammonium linker in rodent plasma.
View article: Supplementary Figure S2. ADC PK profiles from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Supplementary Figure S2. ADC PK profiles from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Pharmacokinetic profile of clearance for three ADCs.
View article: Chemistry Experimental from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Chemistry Experimental from Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
Experimental details for the chemical synthesis of the drug-linkers.
View article: Supplemental Figures and Tables from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Supplemental Figures and Tables from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Supplemental figures include 1)plasma MMAE and ADC measurement. 2) Flow cytometry analysis of CD30 and CD71 of Kapars-299 and Karpas-35R cells, and in vivo ADC activity of these ADCs; and 3)CD30 FACS of Karpas299 and Karpas-35R admixed tum…
View article: Supplemental figure legends from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Supplemental figure legends from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Figure legends for Supplemental Figures S1-S3
View article: Supplemental Figures and Tables from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Supplemental Figures and Tables from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Supplemental figures include 1)plasma MMAE and ADC measurement. 2) Flow cytometry analysis of CD30 and CD71 of Kapars-299 and Karpas-35R cells, and in vivo ADC activity of these ADCs; and 3)CD30 FACS of Karpas299 and Karpas-35R admixed tum…
View article: Data from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Data from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood. In this study, we …
View article: Data from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Data from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood. In this study, we …
View article: Supplemental figure legends from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
Supplemental figure legends from Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models Open
Figure legends for Supplemental Figures S1-S3
View article: Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates
Development of Novel Quaternary Ammonium Linkers for Antibody–Drug Conjugates Open
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody–drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy …