Roberto Andreatini
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View article: Phytotherapy in psychiatry: why psychiatrists should know about it
Phytotherapy in psychiatry: why psychiatrists should know about it Open
There is a substantial use of Complementary and Alternative Medicine (CAM) among both the general population and psychiatric patients, with only a minority of these users disclosing this information to their healthcare providers, including…
View article: Neuroscience-based nomenclature (NbN): the Portuguese version of the new classification for psychopharmacological drugs
Neuroscience-based nomenclature (NbN): the Portuguese version of the new classification for psychopharmacological drugs Open
Neuroscience-based nomenclature (NbN) is a proposal to provide a nomenclature based on neuroscience and pharmacology instead of the old disease-based classification. The NbN is based on the mechanism of action and pharmacological target an…
View article: Antidepressants and memory effects of ketamine under the neuromolecular view: A literature review
Antidepressants and memory effects of ketamine under the neuromolecular view: A literature review Open
Objective: Major Depressive Disorder (MDD) has as diagnostics characteristics chronic deep sadness, anhedonia, sleeping disorder, lower energy, and cognition impairment like memory deficits. Among the pharmacological treatments that have b…
View article: Effect of repeated sodium valproate and topiramate administration on mania‑like behaviors induced by methylphenidate in mice
Effect of repeated sodium valproate and topiramate administration on mania‑like behaviors induced by methylphenidate in mice Open
Novel and effective treatments for mania are needed, and well‑validated animal models are important to reach this goal. The psychostimulant‑induced hyperactivity is the most frequently animal model of mania used. Although this model is val…
View article: Trigeminal neuropathic pain causes changes in affective processing of pain in rats
Trigeminal neuropathic pain causes changes in affective processing of pain in rats Open
Trigeminal neuropathic pain has been modeled in rodents through the constriction of the infraorbital nerve (CCI-ION). Sensory alterations, including spontaneous pain, and thermal and mechanical hyperalgesia are well characterized, but ther…
View article: Diazepam attenuates the effects of cocaine on locomotion, 50‐kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats
Diazepam attenuates the effects of cocaine on locomotion, 50‐kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats Open
Background and Purpose Currently, there is no effective drug to treat cocaine‐use disorder, which affects millions of people worldwide. Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have sho…
View article: Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine release in the nucleus accumbens of rats
Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine release in the nucleus accumbens of rats Open
Background and Purpose Currently, no effective drug exists to treat cocaine use disorders, which affect millions of people worldwide. Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have shown…
View article: The role of prelimbic and anterior cingulate cortices in fear memory reconsolidation and persistence depends on the memory age
The role of prelimbic and anterior cingulate cortices in fear memory reconsolidation and persistence depends on the memory age Open
Reconsolidation is a time-limited process under which reactivated memory content can be modified. Works focused on studying reconsolidation mainly restrict intervention to the moments immediately after reactivation and to recently acquired…
View article: Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation
Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation Open
The persistence of newly acquired memories is supported by the activity of PKMζ, an atypical isoform of protein kinase C (PKC). Whether the activity of conventional and atypical PKC isoforms contributes to reactivated memories to persist i…
View article: SLEEP DEPRIVATION AND NEUROTRANSMISSION IN ANIMAL EXPERIMENTATION: A SCOPING REVIEW
SLEEP DEPRIVATION AND NEUROTRANSMISSION IN ANIMAL EXPERIMENTATION: A SCOPING REVIEW Open
This protocol aims to provide a scoping review about the effects of sleep deprivation on neurotransmission, aiming to produce a ranking of the neurotransmitters and neuromodulators more often researched in association with sleep deprivatio…
View article: Ketamine effects on anxiety and fear-related behaviors: current literature evidence and new findings
Ketamine effects on anxiety and fear-related behaviors: current literature evidence and new findings Open
Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, presents rapid and sustained antidepressant effect in clinical and preclinical studies. Regarding ketamine effects on anxiety, there is a widespread discordance a…
View article: Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials Open
Amantadine is an interesting candidate as new antidepressant drug for the treatment of depression.