Richard M. Smiley
YOU?
Author Swipe
View article: Defining Predictors of Weight Loss Response to Lorcaserin
Defining Predictors of Weight Loss Response to Lorcaserin Open
Context Individual responses to weight loss (WL) medications vary widely and prediction of response remains elusive. Objective We investigated biomarkers associated with use of lorcaserin (LOR), a 5HT2cR agonist that targets proopiomelanoc…
View article: How to Establish and Maintain a Functional Operating Room in a Low-Resource Environment
How to Establish and Maintain a Functional Operating Room in a Low-Resource Environment Open
Although surgery and anesthesia are sometimes carried out under a tent or open air, notably near conflict zones, where issues such as electricity, running water, sterilization, and postoperative care may be extremely limited and unmanageab…
View article: How to Prepare for Short- or Long-Term Surgical Practice in Low- and Middle-Income Countries
How to Prepare for Short- or Long-Term Surgical Practice in Low- and Middle-Income Countries Open
Interest and participation in global health interactions has increased among surgical and anesthesia residents, medical students, and other fully-trained practitioners from high-income areas. These interactions are primarily in "underserve…
View article: RF24 | PSUN95 Defining Predictors of Weight Loss Response to Lorcaserin
RF24 | PSUN95 Defining Predictors of Weight Loss Response to Lorcaserin Open
The need for personalized medicine in obesity is pressing, but we are currently unable to predict individual responses to weight loss (WL) medications. The melanocortin (MC) system consisting of proopiomelanocortin (POMC) and agouti relate…
View article: Randomized trial of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery with or without intrathecal morphine
Randomized trial of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery with or without intrathecal morphine Open
LB TAP block with or without ITM resulted in statistically noninferior postsurgical opioid consumption through 72 h, reduced pruritus, and favorable safety compared with ITM in women undergoing CD.
View article: Pregnancy-specific Adaptations in Leptin and Melanocortin Neuropeptides in Early Human Gestation
Pregnancy-specific Adaptations in Leptin and Melanocortin Neuropeptides in Early Human Gestation Open
Introduction Pregnancy is characterized by increased appetitive drive beginning early in gestation, yet the central mechanisms underlying this adaptation are poorly understood in humans. To elucidate central mechanisms underlying appetite …
View article: Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle
Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle Open
Subjects maintaining a ≥10% dietary weight loss exhibit decreased circulating concentrations of bioactive thyroid hormones and increased skeletal muscle work efficiency largely due to increased expression of more-efficient myosin heavy cha…
View article: Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans
Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans Open
Opioid antagonism stimulates POMC peptide release into CSF in humans. The increase in the CSF β-EP-to-POMC ratio could indicate selective release of processed peptides or an effect on POMC processing. Furthermore, AgRP and cortisol stimula…
View article: Modern Neuraxial Anesthesia for Labor and Delivery
Modern Neuraxial Anesthesia for Labor and Delivery Open
The availability of safe, effective analgesia during labor has become an expectation for women in most of the developed world over the past two or three decades. More than 60% of women in the United States now receive some kind of neuraxia…
View article: Risk Factors and Risk Stratification for Adverse Obstetrical Outcomes After Appendectomy or Cholecystectomy During Pregnancy
Risk Factors and Risk Stratification for Adverse Obstetrical Outcomes After Appendectomy or Cholecystectomy During Pregnancy Open
Approximately 5% of women experience adverse obstetrical outcomes after appendectomy or cholecystectomy during pregnancy. The major risk factors for such outcomes are cervical incompetence, preterm labor during current pregnancy, vaginitis…
View article: Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans
Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans Open
The melanocortin neuronal system, which consists of hypothalamic proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, is a leptin target that regulates energy balance and metabolism, but studies in humans are limited by a …
View article: Evaluation of pain and stress in healthy volunteers undergoing research lumbar punctures
Evaluation of pain and stress in healthy volunteers undergoing research lumbar punctures Open
The use of lumbar punctures (LPs) in clinical research is increasing as emerging data demonstrate that CSF biomarkers can provide useful information about neurophysiology and the pathogenesis of diseases such as Alzheimer disease, amyotrop…
View article: Chronic Thromboembolic Pulmonary Hypertension, Pregnancy, and a Pulmonary Endarterectomy: A Rare Challenge
Chronic Thromboembolic Pulmonary Hypertension, Pregnancy, and a Pulmonary Endarterectomy: A Rare Challenge Open
It is well described that patients with group 1 forms of pulmonary arterial hypertension have a high risk of mortality during pregnancy and in the early postpartum period. However, to the authors' knowledge, the diagnosis and management of…