Sunder Mudaliar
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View article: Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study
Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study Open
OBJECTIVE To determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS) participants. RESEARCH DESIGN AND METHODS In th…
View article: <b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b>
<b>Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression during Long-term Follow-up in the Diabetes Prevention Program Outcomes Study</b> Open
OBJECTIVETo determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS) participants.RESEARCH DESIGN AND METHODSThe DPP randomized adults with predi…
View article: Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks
Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks Open
OBJECTIVE Type 2 diabetes (T2D) and its associated complications develop heterogeneously over decades, but few studies span the progression from prediabetes to clinical events. We investigated whether long-term metabolic trajectories begin…
View article: Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Controlled Trial
Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Controlled Trial Open
Objective: Weight gain with glucose-lowering medications may interfere with effective type 2 diabetes (T2D) management. We evaluated weight change and the effect of weight gain on outcomes over 5 years on four diabetes medications.Research…
View article: Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Controlled Trial
Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Controlled Trial Open
Objective: Weight gain with glucose-lowering medications may interfere with effective type 2 diabetes (T2D) management. We evaluated weight change and the effect of weight gain on outcomes over 5 years on four diabetes medications.Research…
View article: Type 2 Diabetes Moderates the Association Between Amyloid and 1-Year Change in Everyday Functioning in Older Veterans
Type 2 Diabetes Moderates the Association Between Amyloid and 1-Year Change in Everyday Functioning in Older Veterans Open
Background: Type 2 diabetes mellitus (T2DM) affects ∼25% of Veterans, a prevalence rate double that of the general population. T2DM is associated with greater dementia risk and has been shown to exacerbate the impact of Alzheimer’s disease…
View article: Impact of type 2 diabetes on the association between amyloid and 1‐year change in everyday functioning in older Veterans
Impact of type 2 diabetes on the association between amyloid and 1‐year change in everyday functioning in older Veterans Open
Background The prevalence of diabetes in Veterans is 25%, which is double that of the civilian population. Type 2 diabetes (T2D) is associated with greater rates of dementia and has been shown to exacerbate the impact of Alzheimer’s diseas…
View article: 3 Type 2 Diabetes Moderates the Association between Amyloid PET and Attention/Executive Functioning in Older Veterans
3 Type 2 Diabetes Moderates the Association between Amyloid PET and Attention/Executive Functioning in Older Veterans Open
Objective: Type 2 diabetes (T2D) is a risk factor for cognitive impairment/dementia and has been shown to modify the impact of Alzheimer’s disease (AD) biomarkers on cognition and everyday functioning. Studies examining amyloid-ß (Aß), one…
View article: Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes
Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes Open
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function. Objective To evaluate kidney outcomes in the Glycemia Reduction …
View article: Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia
Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia Open
Aim To determine the effects of astaxanthin treatment on lipids, cardiovascular disease (CVD) markers, glucose tolerance, insulin action and inflammation in individuals with prediabetes and dyslipidaemia. Materials and Methods Adult partic…
View article: Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9
Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9 Open
Type 2 Diabetes (T2D) is associated with impaired vascularization of adipose tissue (AT) . IL8, GROα and IL15 are pro-angiogenic myokines, secreted at elevated levels by T2D myotubes. We explored the direct impact of these myokines on AT v…
View article: Sodium‐glucose co‐transporter‐2 inhibitors in patients with type 2 diabetes: Barriers and solutions for improving uptake in routine clinical practice
Sodium‐glucose co‐transporter‐2 inhibitors in patients with type 2 diabetes: Barriers and solutions for improving uptake in routine clinical practice Open
Recent advances in type 2 diabetes (T2D) research have highlighted the benefits of sodium‐glucose co‐transporter‐2 (SGLT‐2) inhibitors, including cardiovascular and renal protection. However, uptake rates of these drugs remain low in patie…
View article: Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9
Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9 Open
Type 2 Diabetes (T2D) is associated with impaired vascularization of adipose tissue (AT) . IL8, GROα and IL15 are pro-angiogenic myokines, secreted at elevated levels by T2D myotubes. We explored the direct impact of these myokines on AT v…
View article: Adipose Tissue from Subjects with Type 2 Diabetes Exhibits Impaired Capillary Formation in Response to GROα: Involvement of MMPs-2 and -9
Adipose Tissue from Subjects with Type 2 Diabetes Exhibits Impaired Capillary Formation in Response to GROα: Involvement of MMPs-2 and -9 Open
Type 2 Diabetes (T2D) is associated with impaired vascularization of adipose tissue (AT) and skeletal muscle. IL8, GROα and IL15 are pro-angiogenic myokines; T2D myotubes secrete high levels of all 3 factors. We aimed to explore the direct…
View article: Changing the diabetes treatment paradigm from glucose control to cardiorenal protection
Changing the diabetes treatment paradigm from glucose control to cardiorenal protection Open
Diabetes is an ancient disease and the first description of this disease has been attributed to Hesy Ra, the chief physician to the Egyptian Pharoah Djoser, nearly 5000 years ago1. Through the centuries, various herbs, chemicals and extrem…
View article: Author response for "A Novel Hypothesis Linking Low Grade Ketonemia to Cardio‐Renal Benefits with SGLT2‐Inhibitors"
Author response for "A Novel Hypothesis Linking Low Grade Ketonemia to Cardio‐Renal Benefits with SGLT2‐Inhibitors" Open
View article: Serum urate and cardiovascular events in the DCCT/EDIC study
Serum urate and cardiovascular events in the DCCT/EDIC study Open
View article: SGLT2 Inhibitor–Induced Low-Grade Ketonemia Ameliorates Retinal Hypoxia in Diabetic Retinopathy—A Novel Hypothesis
SGLT2 Inhibitor–Induced Low-Grade Ketonemia Ameliorates Retinal Hypoxia in Diabetic Retinopathy—A Novel Hypothesis Open
Diabetic retinopathy (DR) is a well-recognized microvascular complication of diabetes. Growing evidence suggests that, in addition to retinal vascular damage, there is significant damage to retinal neural tissue in DR. Studies reveal neuro…
View article: Increasing access to clinical research using an innovative mobile recruitment approach: The (MoRe) concept
Increasing access to clinical research using an innovative mobile recruitment approach: The (MoRe) concept Open
Five of the seven sites experienced an increase in enrollment during the intervention and post-intervention periods. The two sites without an increase in enrollment experienced various extenuating factors. Characteristics of sites using Mo…
View article: Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly
Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly Open
Impaired insulin sensitivity (IS) and β-cell dysfunction result in hyperglycaemia in patients of acromegaly. However, alterations in incretins and their impact on glucose-insulin homeostasis in these patients still remain elusive. Twenty p…
View article: Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity
Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity Open
View article: Reduced peripheral activity leading to hepato‐preferential action of basal insulin peglispro compared with insulin glargine in patients with type 1 diabetes
Reduced peripheral activity leading to hepato‐preferential action of basal insulin peglispro compared with insulin glargine in patients with type 1 diabetes Open
Aims Basal insulin peglispro ( BIL ), a novel PEGylated basal insulin with a large hydrodynamic size, has a delayed absorption and reduced clearance that prolongs the duration of action. The current study compared the effects of BIL and in…
View article: Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance
Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance Open
To determine the efficacy of pioglitazone to prevent type 2 diabetes in older compared to younger adults with pre-diabetes. Six hundred two participants with impaired glucose tolerance (IGT) were randomized in double blind fashion to place…
View article: Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes
Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes Open
Skeletal muscle secretes factors, termed myokines. We employed differentiated human skeletal muscle cells (hSMC) cultured from Type 2 diabetic (T2D) and non-diabetic (ND) subjects to investigate the impact of T2D on myokine secretion. Foll…
View article: Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW
Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW Open
1) The protective effect of PIO on incidence of diabetes attenuates after discontinuation of therapy, 2) cumulative incidence of diabetes in individuals exposed to PIO remained significantly (56%) lower than PLAC and a greater number of PI…
View article: A Novel Insulin Resistance Index to Monitor Changes in Insulin Sensitivity and Glucose Tolerance: the ACT NOW Study
A Novel Insulin Resistance Index to Monitor Changes in Insulin Sensitivity and Glucose Tolerance: the ACT NOW Study Open
In IGT subjects, Quantose M(Q) parallels changes in insulin sensitivity and glucose tolerance with pioglitazone therapy. Due to its strong correlation with improved insulin sensitivity and its ease of use, Quantose M(Q) may serve as a usef…