Timothy R. Billiar
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View article: Multi-modal single-cell sequencing reveals new features in peripheral circulating monocytes in trauma patients aligns with fast recovery 2936
Multi-modal single-cell sequencing reveals new features in peripheral circulating monocytes in trauma patients aligns with fast recovery 2936 Open
Description Previous transcriptomic studies revealed a dramatic upregulation of inflammation and simultaneously downregulation of MHCII and IFN signaling pathways after trauma which gradually return to baseline. The magnitude of these chan…
View article: Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis
Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis Open
Sepsis is a life-threatening disease caused by a dysfunctional host response to infection. During sepsis, inflammation-related immunosuppression is the critical factor causing secondary infection and multiple organ dysfunction syndrome. Th…
View article: Caspase-11 regulates systemic inflammation and cell death in a cell-specific manner after trauma with shock
Caspase-11 regulates systemic inflammation and cell death in a cell-specific manner after trauma with shock Open
Severe trauma releases damage-associated molecular patterns (DAMPs), which activate the immune system via pattern recognition receptors. This triggers inflammatory cascades that can lead to systemic inflammatory response syndrome, immunosu…
View article: Correction: Plumbagin protects mice from lethal Sepsis by modulating immunometabolism upstream of PKM2
Correction: Plumbagin protects mice from lethal Sepsis by modulating immunometabolism upstream of PKM2 Open
View article: Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER– breast cancer
Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER– breast cancer Open
Tumor immunosuppression affects survival and treatment efficacy. Tumor NOS2/COX2 coexpression strongly predicts poor outcome in estrogen receptor-negative (ER-) breast cancer by promoting metastasis, drug resistance, cancer stemness, and i…
View article: Author Correction: PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Author Correction: PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation Open
View article: Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis
Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis Open
View article: A neuroimmune pathway drives bacterial infection
A neuroimmune pathway drives bacterial infection Open
Pathogen-induced septic death presents a substantial public health challenge, with its neuroimmune mechanisms largely unexplored. Our study investigates neurotransmitter modulation of ACOD1 expression, a regulator of immunometabolism activ…
View article: Aicardi-Goutières Syndrome Associated <i>ADAR</i> G1007R mutation dominantly induces neuroinflammation in mouse brain
Aicardi-Goutières Syndrome Associated <i>ADAR</i> G1007R mutation dominantly induces neuroinflammation in mouse brain Open
The ADAR G 1007 R mutation is one of the most frequent mutations found in type six Aicardi-Goutières Syndrome (AGS), a severe inflammatory encephalopathy in pediatric patients. We report here a mouse model bearing an human equivalent ADAR …
View article: Value of animal sepsis research in navigating the translational labyrinth
Value of animal sepsis research in navigating the translational labyrinth Open
View article: Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table II summarizes �8+ T cells in designated regions of the tumors.
View article: Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Modulation of EpCAM and CD44v6+.
View article: Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Immune and tumor quantification
View article: Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Fig. 4. Supplementary Fig. 4. Spatial UMAP analysis of CD8+/-NOS2+/-COX2+/- phenotypes in Deceased vs Alive patient tumors. Single cell neighborhood profile summary.
View article: Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor NOS2 and COX2 expression induced by IFNg and TNFa
View article: Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Fig. 4. Supplementary Fig. 4. Spatial UMAP analysis of CD8+/-NOS2+/-COX2+/- phenotypes in Deceased vs Alive patient tumors. Single cell neighborhood profile summary.
View article: Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table II summarizes �8+ T cells in designated regions of the tumors.
View article: Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Spatial dot plot of CD8+/-NOS2+/-COX2+/- phenotypes in tumor from deceased patient.
View article: Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table I summarizes pathological features of tumor immune microenvironment where NOS2+ inflamed regions are significantly higher in tumors from Deceased patients.
View article: Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor NOS2 and COX2 expression induced by IFNg and TNFa
View article: Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor analysis of NOS2 and COX2.
View article: Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table I summarizes pathological features of tumor immune microenvironment where NOS2+ inflamed regions are significantly higher in tumors from Deceased patients.
View article: Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor analysis of NOS2 and COX2.
View article: Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Modulation of EpCAM and CD44v6+.
View article: Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Spatial dot plot of CD8+/-NOS2+/-COX2+/- phenotypes in tumor from deceased patient.
View article: Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Immune and tumor quantification
View article: Roles of TLR4 in macrophage immunity and macrophage-pulmonary vascular/lymphatic endothelial cell interactions in sepsis
Roles of TLR4 in macrophage immunity and macrophage-pulmonary vascular/lymphatic endothelial cell interactions in sepsis Open
In sepsis, acute lung injury (ALI) is a severe complication and a leading cause of death, involving complex mechanisms that include cellular and molecular interactions between immune and lung parenchymal cells. In recent decades, the role …
View article: High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation
High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation Open
Early blood product resuscitation is often essential for optimal trauma care. However, the effects of different products on the underlying trauma-induced coagulopathy and immune dysfunction are not well described. Here, we use high-dimensi…
View article: Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia Open
View article: High-grade liver injury: outcomes with a trauma surgery–liver surgery collaborative approach
High-grade liver injury: outcomes with a trauma surgery–liver surgery collaborative approach Open
Background Operative mortality for high-grade liver injury (HGLI) remains 42% to 66%, with near-universal mortality after retrohepatic caval injury. The objective of this study was to evaluate mortality and complications of operative and n…