Rong Yin
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View article: Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer
Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer Open
Drug-tolerant persister (DTP) cells drive therapeutic resistance in EGFR-mutant lung adenocarcinoma. Using single-cell RNA sequencing, we identified a clinically significant RGS5+MYL9+ cancer-associated fibroblast (CAF) population that was…
View article: A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models Open
Timely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory i…
View article: Human intestinal fungus Clavispora lusitaniae attenuates colitis through Pyruvate decarboxylase-derived Indole-3-ethanol
Human intestinal fungus Clavispora lusitaniae attenuates colitis through Pyruvate decarboxylase-derived Indole-3-ethanol Open
Gut mycobiome dysbiosis has been implicated in inflammatory bowel disease (IBD). However, it remains unknown whether specific fungal species identified by sequencing directly contribute to IBD pathogenesis. Here, based on analysis of three…
View article: Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors
Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors Open
Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B ce…
View article: Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations
Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations Open
Summary Background Capillary malformation (CM) is a congenital vascular anomaly affecting the skin, mucosa, and brain, yet the understanding of its vascular pathogenesis remains limited. Methods We applied spatial whole-transcriptome profi…
View article: Supplementary Fig.S11 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S11 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Consensus clustering analysis of expression data.
View article: Supplementary Fig.S22 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S22 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
The proportion of different mutational signatures that underlie the multi-base substitutions (MBS) over different mutation periods.
View article: Supplementary Fig.S18 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S18 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
The association between frequent mutations in coding driver genes and noncoding driver elements.
View article: Supplementary Fig.S1 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S1 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
The number of somatic mutations over different mutation periods.
View article: Supplementary Fig.S24 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S24 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
The proportion of different mutational signatures that underlie the non-clustered, Omikli, and other mutations over different mutation periods.
View article: Supplementary Fig.S14 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S14 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the mutational rates of the detected drivers in three clusters of patients.
View article: Supplementary Fig.S12 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S12 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Sex differences and genomic distribution of EGFR clonal mutations.
View article: Supplementary Fig.S5 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S5 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Linear regression analysis of the tumor mutational burden (TMB) and smoking pack years in the Nanjing-Huaxi Lung Cancer Cohort.
View article: Supplementary Fig.S19 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S19 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Linear regression of smoking pack years with the number of smoking-related mutations and smoking-related early clonal mutations.
View article: Supplementary Fig.S17 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S17 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the mutational rates of the detected noncoding drivers in three clusters of patients.
View article: Supplementary Fig.S3 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S3 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Multi-region sampling analysis of shared and private mutations along with different mutations periods.
View article: Supplementary Table S4 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Table S4 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Relative timing of mutations in the non-coding regulatory regions of genes in the pathway.
View article: Supplementary Table S5 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Table S5 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Demographic characteristics of study participants with multi-region LUAD tissues samples.
View article: Supplementary Fig.S2 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S2 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
The mutational burden of somatic mutations over different mutation periods across different genomic regions.
View article: Supplementary Table S2 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Table S2 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Clinical characteristics of NHLCC participants.
View article: Supplementary Fig.S15 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S15 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the mutation frequencies of driver genes between Asian cohorts (NHLCC and East Asian) and TCGA cohorts among smokers and non-smokers.
View article: Supplementary Fig.S8 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S8 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Negative binomial mixed-effect model to test the non-linearity between tumor mutational burden (TMB) and smoking pack years in both East Asian and TCGA European populations.
View article: Supplementary Fig.S10 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S10 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Kaplan–Meier survival curves comparing the clinical outcome of patients with a high level of early clonal mutations (among the top 10% of the proportion of early clonal mutations) versus others in the TCGA and NHLCC cohort.
View article: Supplementary Table S6 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Table S6 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Enrichment of shared and private mutations in mutations with different periods.
View article: Data from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Data from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Lung adenocarcinoma (LUAD) is a heterogeneous disease with substantial genomic differences between individuals of Chinese and European ancestries. Deciphering the timing of driver mutations may lead to insights into tumor evolution that ca…
View article: Supplementary Fig.S9 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S9 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the ratio of early clonal mutations between females and males among populations with different smoking statuses.
View article: Supplementary Fig.S13 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S13 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the frequency of early clonal mutations in driver genes among patients with different smoking status or gender.
View article: Supplementary Fig.S20 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S20 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Fold changes between relative proportions of early and late clonal mutations attributed to specific combined mutational signature types.
View article: Supplementary Fig.S4 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Supplementary Fig.S4 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients Open
Comparison of the ratio of early clonal mutations between smokers and non-smokers among males and females respectively.