Daniel A. Hunter
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View article: Gene therapy ameliorates neuromuscular pathology in CLN3 disease
Gene therapy ameliorates neuromuscular pathology in CLN3 disease Open
CLN3 disease is a neuronopathic lysosomal storage disorder that severely impacts the central nervous system (CNS) while also inducing notable peripheral neuromuscular symptoms. Although considerable attention has been directed towards the …
View article: Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice
Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice Open
Background and aims Severe gastrointestinal (GI) symptoms occur in people with CLN3 disease, a neurodegenerative disorder. If left untreated these GI symptoms compromise life quality and may contribute to death. We hypothesized GI symptoms…
View article: Limited Nerve Regeneration across Acellular Nerve Allografts (ANAs) Coincides with Changes in Blood Vessel Morphology and the Development of a Pro-Inflammatory Microenvironment
Limited Nerve Regeneration across Acellular Nerve Allografts (ANAs) Coincides with Changes in Blood Vessel Morphology and the Development of a Pro-Inflammatory Microenvironment Open
The use of acellular nerve allografts (ANAs) to reconstruct long nerve gaps (>3 cm) is associated with limited axon regeneration. To understand why ANA length might limit regeneration, we focused on identifying differences in the regenerat…
View article: Lidocaine Nerve Block Diminishes the Effects of Therapeutic Electrical Stimulation to Enhance Nerve Regeneration in Rats
Lidocaine Nerve Block Diminishes the Effects of Therapeutic Electrical Stimulation to Enhance Nerve Regeneration in Rats Open
Background: Although electrical stimulation (ES) can improve nerve regeneration, the impact of nerve block, such as lidocaine (Lido), on the therapeutic benefits of ES remains unclear. We used a rat tibial nerve transection-and-repair mode…
View article: Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model
Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model Open
Background: Treatments to manage painful neuroma are needed. An operative strategy that isolates and controls chaotic axonal growth could prevent neuroma. Using long acellular nerve allograft to “cap” damaged nerve could control axonal reg…
View article: Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery
Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery Open
Background: Acellular nerve allografts have been used successfully and with increasing frequency to reconstruct nerve injuries. As their use has been expanded to treat longer gap, larger diameter nerve injuries, some failed cases have been…
View article: The Effects of Intraoperative Electrical Stimulation on Regeneration and Recovery After Nerve Isograft Repair in a Rat Model
The Effects of Intraoperative Electrical Stimulation on Regeneration and Recovery After Nerve Isograft Repair in a Rat Model Open
Background: Therapeutic electrical stimulation (ES) applied to repaired nerve is a promising treatment option to improve regeneration. However, few studies address the impact of ES following nerve graft reconstruction. The purpose of this …
View article: CCDC 1984333: Experimental Crystal Structure Determination
CCDC 1984333: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1984334: Experimental Crystal Structure Determination
CCDC 1984334: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1984335: Experimental Crystal Structure Determination
CCDC 1984335: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries
Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries Open
Introduction Neuroenhancing therapies are desired because repair of nerve injuries can fail to achieve recovery. We compared two neuroenhancing therapies, electrical stimulation (ES) and systemic tacrolimus (FK506), for their capabilities …
View article: Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic<i>Thy1-Gfp</i>Rat Model
Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic<i>Thy1-Gfp</i>Rat Model Open
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View article: Neuroma Management: Capping Nerve Injuries With an Acellular Nerve Allograft Can Limit Axon Regeneration
Neuroma Management: Capping Nerve Injuries With an Acellular Nerve Allograft Can Limit Axon Regeneration Open
Background: Management of painful neuromas continues to challenge clinicians. Controlling axon growth to prevent neuroma has gained considerable traction. A logical extension of this idea is to therefore develop an approach to control and …
View article: Abstract 1: T Cells Contribute To Peripheral Nerve Regeneration Through Acellular Nerve Allografts Via Regulation Of Il-4
Abstract 1: T Cells Contribute To Peripheral Nerve Regeneration Through Acellular Nerve Allografts Via Regulation Of Il-4 Open
PURPOSE: Peripheral nerve injury remains a significant public health issue. Traumatic nerve injuries often necessitate surgical repair with nerve grafts. While autologous nerve grafts are the clinical standard, acellular nerve allograft (A…
View article: Increasing Nerve Autograft Length Increases Senescence and Reduces Regeneration
Increasing Nerve Autograft Length Increases Senescence and Reduces Regeneration Open
Background: Nerve grafting with an autograft is considered the gold standard. However, the functional outcomes of long (>3 cm) nerve autografting are often poor. The authors hypothesized that a factor contributing to these outcomes is the …
View article: Transgenic SCs expressing GDNF‐IRES‐DsRed impair nerve regeneration within acellular nerve allografts
Transgenic SCs expressing GDNF‐IRES‐DsRed impair nerve regeneration within acellular nerve allografts Open
Providing temporally regulated glial cell line‐derived neurotrophic factor (GDNF) to injured nerve can promote robust axon regeneration. However, it is poorly understood why providing highly elevated levels of GDNF to nerve can lead to axo…
View article: Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts
Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts Open
Introduction: Acellular nerve allografts (ANAs) yield less consistent favorable outcomes compared with autografts for long gap reconstructions. We evaluated whether a hybrid ANA can improve 6‐cm gap reconstruction. Methods: Rat sciatic ner…
View article: Abstract 51: Acellularized Nerve Allografts Guide Axon Regeneration to a Controlled Termination in a Rat Model
Abstract 51: Acellularized Nerve Allografts Guide Axon Regeneration to a Controlled Termination in a Rat Model Open
PURPOSE: The myriad of existing management approaches to neuroma highlight the difficulty in treating this clinical entity, and no satisfactory approach has been developed. Evaluation of “off-the-shelf” acellular nerve allografts (ANAs) as…
View article: Abstract 53: Discrepancies in Senescence and Protein Expression from Cells in Nerve Autografts Compared to Injured Nerve
Abstract 53: Discrepancies in Senescence and Protein Expression from Cells in Nerve Autografts Compared to Injured Nerve Open
PURPOSE: Outcomes of nerve autografting are often merely adequate to poor, especially as the nerve gap increases in length. We hypothesize senescent cells accumulate in longer grafts and resultant changes in protein expression contribute t…
View article: Assessment of the link between in utero exposure to 2-aminoanthracene (2AA) and type-1 diabetes (T1D)
Assessment of the link between in utero exposure to 2-aminoanthracene (2AA) and type-1 diabetes (T1D) Open
It appears that systemic effects of 2AA ingestion were mild in the neonates. Further assessments of pups who lived longer than two weeks could be a useful way to measure the progression and possibly further support our hypothesis that 2AA …
View article: Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts
Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts Open
Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal regeneration across long defects (>3 cm). Causes for this deficiency are poorly understood. In this study, we determined what cells are present …
View article: Robust Axonal Regeneration in a Mouse Vascularized Composite Allotransplant Model Undergoing Delayed Tissue Rejection
Robust Axonal Regeneration in a Mouse Vascularized Composite Allotransplant Model Undergoing Delayed Tissue Rejection Open
Background: Nerve regeneration in vascularized composite allotransplantation (VCA) is not well understood. Allogeneic transplant models experience complete loss of nerve tissue and axonal regeneration without immunosuppressive therapy. The…