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View article: Potential in-host evolution of <i>Klebsiella pneumoniae</i> ST147: convergence and the role of capsular alterations in morphotype diversity
Potential in-host evolution of <i>Klebsiella pneumoniae</i> ST147: convergence and the role of capsular alterations in morphotype diversity Open
Klebsiella pneumoniae , an important opportunistic pathogen, is traditionally classified into classic and hypervirulent pathotypes. Convergent strains combining antimicrobial resistance (AMR) and hypervirulence have emerged globally, posin…
View article: The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions
The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions Open
Introduction Streptococcus pneumoniae is a human pathobiont that asymptomatically colonizes the upper respiratory tract but can cause severe diseases such as pneumonia, sepsis, and meningitis, as well as non-invasive infections like otitis…
View article: The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in <i>Streptococcus pneumoniae</i>
The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in <i>Streptococcus pneumoniae</i> Open
In all living cells, molecular chaperones and ATP-dependent proteases are essential for protein homeostasis. The ClpXP protease is a chaperone-protease complex conserved between bacteria and mitochondria. Proteolytic activity resides in th…
View article: Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection
Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection Open
View article: The olfactory pathway in the peracarid crustacean <i>Parhyale hawaiensis</i> (Malacostraca): new insights into the evolution of olfactory processing in Pancrustacea
The olfactory pathway in the peracarid crustacean <i>Parhyale hawaiensis</i> (Malacostraca): new insights into the evolution of olfactory processing in Pancrustacea Open
Our current understanding of the functional morphology of olfactory systems in arthropods largely relies on information obtained in hexapods. Existing analyses of the olfactory pathway in crustacean representatives have suggested that thes…
View article: Transformation of the drug ibuprofen by Priestia megaterium: reversible glycosylation and generation of hydroxylated metabolites
Transformation of the drug ibuprofen by Priestia megaterium: reversible glycosylation and generation of hydroxylated metabolites Open
View article: Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys
Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys Open
Background/Objective Endoprostheses might fail due to complications such as implant loosening or periprosthetic infections. The surface topography of implant materials is known to influence osseointegration and attachment of pathogenic bac…
View article: Efficient delivery of small RNAs to podocytes<i>in vitro</i>by direct exosome transfection
Efficient delivery of small RNAs to podocytes<i>in vitro</i>by direct exosome transfection Open
Summary Podocytes are a crucial component of the glomerular filtration barrier and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases. Exosomal small RNAs play a key role in cell-cell communication i…
View article: Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain
Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain Open
Background Convergence of Klebsiella pneumoniae (KP) pathotypes has been increasingly reported in recent years. These pathogens combine features of both multidrug-resistant and hypervirulent KP. However, clinically used indicators for hype…
View article: In-vitro biofilm removal from TiUnite® implant surface with an air polishing and two different plasma devices
In-vitro biofilm removal from TiUnite® implant surface with an air polishing and two different plasma devices Open
Background We investigated the efficacy of two different cold atmospheric pressure jet plasma devices (CAP09 and CAPmed) and an air polishing device with glycine powder (AP) either applied as monotherapies or combined therapies (AP + CAP09…
View article: Transformation of the drug ibuprofen by<i>Priestia megaterium</i>: Reversible glycosylation and generation of hydroxylated metabolites
Transformation of the drug ibuprofen by<i>Priestia megaterium</i>: Reversible glycosylation and generation of hydroxylated metabolites Open
As one of the most-consumed drugs worldwide, ibuprofen (IBU) reaches the environment in considerable amounts as environmental pollutant, necessitating studies of its further biotransformation as potential removal mechanism. Therefore, we s…
View article: In-host evolution of classic to convergent<i>Klebsiella pneumoniae</i>sequence type 147 isolates and impact of associated capsular changes on different morphotypes
In-host evolution of classic to convergent<i>Klebsiella pneumoniae</i>sequence type 147 isolates and impact of associated capsular changes on different morphotypes Open
Klebsiella pneumoniae , an important opportunistic pathogen, has long been categorized into two distinct pathotypes: the often multidrug-resistant classic (cKp) and the highly virulent hypervirulent (hvKp). However, a recent global trend h…
View article: Temperatures above 37°C increase virulence of a convergent<i>Klebsiella pneumoniae</i>sequence type 307 strain
Temperatures above 37°C increase virulence of a convergent<i>Klebsiella pneumoniae</i>sequence type 307 strain Open
Hypermucoviscosity in Klebsiella pneumoniae is often related to the overexpression of capsular polysaccharides, regulated by complex biosynthetic mechanisms in response to external cues. However, little is known about the processes involve…
View article: TLR4 sensing of IsdB of <i>Staphylococcus aureus</i> induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade
TLR4 sensing of IsdB of <i>Staphylococcus aureus</i> induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade Open
The iron-regulated surface determinant protein B (IsdB) of Staphylococcus aureus is involved in the acquisition of iron from hemoglobin. Moreover, IsdB elicits an adaptive immune response in mice and humans. Here, we show that IsdB also ha…
View article: Natural phenolic compounds as biofilm inhibitors of multidrug-resistant Escherichia coli – the role of similar biological processes despite structural diversity
Natural phenolic compounds as biofilm inhibitors of multidrug-resistant Escherichia coli – the role of similar biological processes despite structural diversity Open
Multidrug-resistant gram-negative pathogens such as Escherichia coli have become increasingly difficult to treat and therefore alternative treatment options are needed. Targeting virulence factors like biofilm formation could be one such o…
View article: Investigation of TGF‐<i>α</i>‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates
Investigation of TGF‐<i>α</i>‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates Open
The immortalized mouse liver cell line TAMH has been described as a valuable tool for studying hepatotoxic mechanisms, but until now, it has only been reported to grow as a monolayer in culture. However, culturing hepatocytes as three‐dime…
View article: In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants
In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants Open
Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants’ complex geometry and rough surfaces providing niches for microbial biofilms. A modifi…
View article: The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties
The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties Open
View article: Effect of Iron Limitation, Elevated Temperature, and Florfenicol on the Proteome and Vesiculation of the Fish Pathogen Aeromonas salmonicida
Effect of Iron Limitation, Elevated Temperature, and Florfenicol on the Proteome and Vesiculation of the Fish Pathogen Aeromonas salmonicida Open
We analyzed the proteomic response of the Gram-negative fish pathogen A. salmonicida to iron limitation, an elevated incubation temperature, and the antibiotic florfenicol. Proteins from different subcellular fractions (cytosol, inner memb…
View article: Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress Open
C. difficile is an important anaerobe pathogen causing mild to severe infections of the gastrointestinal tract. To avoid relapse of the infection following antibiotic therapy, antibiotics are needed that efficiently eradicate C. difficile …
View article: A Novel Antimicrobial Metabolite Produced by Paenibacillus apiarius Isolated from Brackish Water of Lake Balkhash in Kazakhstan
A Novel Antimicrobial Metabolite Produced by Paenibacillus apiarius Isolated from Brackish Water of Lake Balkhash in Kazakhstan Open
Four aerobic bacteria with bacteriolytic capabilities were isolated from the brackish water site Strait Uzynaral of Lake Balkhash in Kazakhstan. The morphology and physiology of the bacterial isolates have subsequently been analyzed. Using…
View article: The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties
The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties Open
Understanding the nanoparticle-cell interactions in physiological media is vital in determining the biological fate of the nanoparticles (NPs). These interactions depend on the physicochemical properties of the NPs and their colloidal beha…
View article: Efficiency of biofilm removal by combination of water jet and cold plasma: an in-vitro study
Efficiency of biofilm removal by combination of water jet and cold plasma: an in-vitro study Open
View article: Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile
Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile Open
The anaerobic bacterium Clostridioides difficile represents one of the most problematic pathogens, especially in hospitals. Dysbiosis has been proven to largely reduce colonization resistance against this intestinal pathogen. The beneficia…
View article: Proteome analysis of the Gram-positive fish pathogen Renibacterium salmoninarum reveals putative role of membrane vesicles in virulence
Proteome analysis of the Gram-positive fish pathogen Renibacterium salmoninarum reveals putative role of membrane vesicles in virulence Open
Bacterial kidney disease (BKD) is a chronic bacterial disease affecting both wild and farmed salmonids. The causative agent for BKD is the Gram-positive fish pathogen Renibacterium salmoninarum . As treatment and prevention of BKD have pro…
View article: Efficiency of cold atmospheric plasma, cleaning powders and their combination for biofilm removal on two different titanium implant surfaces
Efficiency of cold atmospheric plasma, cleaning powders and their combination for biofilm removal on two different titanium implant surfaces Open
Objectives Biofilm removal is the decisive factor for the control of peri-implantitis. Cold atmospheric pressure plasma (CAP) can become an effective aid due to its ability to destroy and to inactivate bacterial biofilm residues. This stud…
View article: The podocyte-specific knockout of palladin in mice with a 129 genetic background affects podocyte morphology and the expression of palladin interacting proteins
The podocyte-specific knockout of palladin in mice with a 129 genetic background affects podocyte morphology and the expression of palladin interacting proteins Open
Proper and size selective blood filtration in the kidney depends on an intact morphology of podocyte foot processes. Effacement of interdigitating podocyte foot processes in the glomeruli causes a leaky filtration barrier resulting in prot…
View article: Proteome analysis of the Gram-positive fish pathogen Renibacterium salmoninarum reveals putative role of membrane vesicles in virulence
Proteome analysis of the Gram-positive fish pathogen Renibacterium salmoninarum reveals putative role of membrane vesicles in virulence Open
The bacterial kidney disease (BKD) is a chronic bacterial disease affecting both wild and farmed salmonids. The causative agent for BKD is the Gram-positive fish pathogen Renibacterium salmoninarum. As treatment and prevention of BKD has p…
View article: Correction to: Biotransformation of bisphenol a analogues by the biphenyl-degrading bacterium Cupriavidus basilensis - a structure-biotransformation relationship
Correction to: Biotransformation of bisphenol a analogues by the biphenyl-degrading bacterium Cupriavidus basilensis - a structure-biotransformation relationship Open
A Correction to this paper has been published: 10.1007/s00253-021-11421-9
View article: A 20‐kb lineage‐specific genomic region tames virulence in pathogenic amphidiploid <i>Verticillium longisporum</i>
A 20‐kb lineage‐specific genomic region tames virulence in pathogenic amphidiploid <i>Verticillium longisporum</i> Open
Amphidiploid fungal Verticillium longisporum strains Vl43 and Vl32 colonize the plant host Brassica napus but differ in their ability to cause disease symptoms. These strains represent two V . longisporum lineages derived from different hy…