Explanipedia

IMG-92. An evidence-based framework for postoperative surveillance of meningioma Open

Bethany C. Berry, M. Marasco, Umika Paul, Rachael W. Sirianni · 2025

Meningiomas frequently recur after surgery. Existing guidelines for postoperative surveillance are based on customary practices or limited data. This may result in excessive or inadequate surveillance. We compared 8 studies involving 1,519…

An evidence-based framework for postoperative surveillance of meningioma Open

Brittany Owusu‐Adjei, Jeewoo Chelsea Lim, Connie Hou, Constance J. Mietus, Rrita Daci , et al. · 2024

Background Meningiomas frequently recur after surgery. Existing guidelines for postoperative surveillance are based on customary practices or limited data. This may result in excessive or inadequate surveillance. Methods We compared 8 stud…

Central nervous system distributional kinetics of selected histone deacetylase inhibitors Open

Wenqiu Zhang, Ju‐Hee Oh, Wenjuan Zhang, Courtney C. Aldrich, Rachael W. Sirianni , et al. · 2024

Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability Open

Wenqiu Zhang, Ju‐Hee Oh, Wenjuan Zhang, Courtney C. Aldrich, Rachael W. Sirianni , et al. · 2024

Acute brain injury and nanomedicine: sex as a biological variable Open

Amberlyn Simmons, Olivia Mihalek, Heather A. Bimonte Nelson, Rachael W. Sirianni, Sarah E. Stabenfeldt · 2024

Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new t…

Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors Open

Wenqiu Zhang, Ju‐Hee Oh, Wenjuan Zhang, Sneha Rathi, Jon D. Larson , et al. · 2023

Surgical Resection Facilitates the Access of Intravenously Administered Nanoparticles to Brain Vasculature in Mice Open

Sara Belko, Oluwatobi Helen Babayemi, Cassandra Baker, Martha Fowler, Milad Pourbaghi‐Masouleh , et al. · 2021

Nanoparticle systems are often used to facilitate drug delivery to the central nervous system (CNS). There are many clinical situations in which CNS tissue might be removed prior to administration of a therapeutic nanoparticle; however, th…

EMBR-28. CNS DISTRIBUTIONAL KINETICS OF PANOBINOSTAT IN THE MOUSE Open

Wenqiu Zhang, Afroz S. Mohammad, Rachael W. Sirianni, William F. Elmquist · 2021

Medulloblastoma (MB) is the most common malignant pediatric brain tumor and has the potential for leptomeningeal spread, often responsible for the preponderance of morbidity and mortality in MB patients. Adverse sequelae following high dos…

β-Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors Open

Sauradip Chaudhuri, Martha J. Fowler, Cassandra Baker, Sylwia A. Stopka, Michael S. Regan , et al. · 2021

Therapeutic development of histone deacetylase inhibitors (HDACi) has been hampered by a number of barriers to drug delivery, including poor solubility and inadequate tissue penetration. Nanoparticle encapsulation could be one approach to …

Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause Open

Alesia V. Prakapenka, Verónica Peña, Isabel M. Strouse, Steven N. Northup-Smith, Ally R. Schrier , et al. · 2020

Exogenously administered 17β-estradiol (E2) can improve spatial learning and memory, although E2 also exerts undesired effects on peripheral organs. Clinically, E2 has been solubilized in cyclodextrin for intranasal administration, which e…

Poly(lactic-co-glycolic Acid) Nanoparticle Encapsulated 17β-Estradiol Improves Spatial Memory and Increases Uterine Stimulation in Middle-Aged Ovariectomized Rats Open

Alesia V. Prakapenka, Alicia M. Quihuis, Catherine G. Carson, Shruti Patel, Heather A. Bimonte‐Nelson , et al. · 2020

Hormone therapy that contains 17β-estradiol (E2) is used commonly for treatment of symptoms associated with menopause. E2 treatment has been shown to improve cognitive function following the decrease in ovarian hormones that is characteris…

DDEL-10. A NANOPARTICLE PLATFORM FOR INTRATHECAL DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR (HDACi) PANOBINOSTAT IN METASTATIC OR RECURRENT MEDULLOBLASTOMA Open

Sauradip Chaudhuri, Afroz S. Mohammad, Wenqui Zhang, Cassandra Baker, Colton W. Broughton , et al. · 2020

INTRODUCTION Panobinostat is a histone deacetylase inhibitor (HDACi) that is a clinical candidate for treatment of pediatric medulloblastoma and diffuse intrinsic pontine glioma. Panobinostat is poorly water-soluble and experiences a numbe…

DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL Open

Rachael W. Sirianni, Natasha Kharas, Bangning Yu, Christopher F. Janssen, Amanda Trimble , et al. · 2020

OBJECTIVE This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS Four rhesus macaque monke…

High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model Open

David I. Sandberg, Natasha Kharas, Bangning Yu, Christopher F. Janssen, Amanda Trimble , et al. · 2020

OBJECTIVE Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (so…

Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS Open

David X. Medina, Eugene P. Chung, Collin D. Teague, Robert Bowser, Rachael W. Sirianni · 2020

Dysregulation of the retinoic acid (RA) signaling pathway is observed in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here, we investigated the therapeutic potential of retinoid activation via the RA receptor …

β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors Open

Sauradip Chaudhuri, Martha Fowler, Afroz S. Mohammad, Wenqui Zhang, Cassandra Baker , et al. · 2020

Here, we describe a simple, efficient formulation of a novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) to achieve this goal. We observed that network architecture was a critical determinant of CDN encapsulation of candi…

β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors Open

Sauradip Chaudhuri, Martha Fowler, Afroz S. Mohammad, Wenqui Zhang, Cassandra Baker , et al. · 2020

Here, we describe a simple, efficient formulation of a novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) to achieve this goal. We observed that network architecture was a critical determinant of CDN encapsulation of cand…

Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles Open

Eugene P. Chung, Jennifer D. Cotter, Alesia V. Prakapenka, Rebecca L. Cook, Danielle M. DiPerna , et al. · 2020

Alternative routes of administration are one approach that could be used to bypass the blood–brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused on intranasal delivery of polymer nanopartic…

Intrathecal drug delivery in the era of nanomedicine Open

Martha J. Fowler, Jennifer D. Cotter, Brittany Knight, Eva M. Sevick‐Muraca, David I. Sandberg , et al. · 2020

Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice Open

Kyle T. Householder, Shruti Dharmaraj, David I. Sandberg, Robert J. Wechsler‐Reya, Rachael W. Sirianni · 2019

pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma Open

Kyle T. Householder, Danielle M. DiPerna, Eugene P. Chung, Anne Rosa Luning, Duong Thanh Nguyen , et al. · 2018

Histone deacetylases (HDACs) are known to be key enzymes in cancer development and progression through their modulation of chromatin structure and the expression and post-translational modification of numerous proteins. Aggressive dediffer…

Modeling Microenvironmental Regulation of Glioblastoma Stem Cells: A Biomaterials Perspective Open

John M. Heffernan, Rachael W. Sirianni · 2018

Following diagnosis of a glioblastoma (GBM) brain tumor, surgical resection, chemotherapy, and radiation together yield a median patient survival of only 15 months. Importantly, standard treatments fail to address the dynamic regulation of…

Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for Controlled Delivery of 17β-Estradiol Open

Alesia V. Prakapenka, Heather A. Bimonte‐Nelson, Rachael W. Sirianni · 2017

PNIPAAm-co-Jeffamine® (PNJ) scaffolds as in vitro models for niche enrichment of glioblastoma stem-like cells Open

John M. Heffernan, James McNamara, Sabine Borwege, Brent L. Vernon, Nader Sanai , et al. · 2017

Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo Open

David X. Medina, Kyle T. Householder, Ricki Ronea Ceton, Tina Kovalik, John M. Heffernan , et al. · 2017

Understanding of the mechanisms by which systemically administered nanoparticles achieve delivery across biological barriers remains incomplete, due in part to the challenge of tracking nanoparticle fate in the body. Here, we develop a new…

IMST-50. DEVELOPMENT AND EXPRESSION OF A T CELL ENGAGER TARGETED TO GLIOBLASTOMA BY CHLOROTOXIN Open

Rebecca L. Cook, Lydia R. Meador, Apisara Ausvasomrit, Thanchanok Boonsompong, Braeden Scott Schaefer , et al. · 2016

Bispecific T cell activating molecules are potent inducers of T cell destruction against target cells of interest and are commonly composed of two single chain variable fragments from distinct antibodies held together by a short peptide li…

TMIC-22. ENRICHMENT OF GLIOBLASTOMA STEM CELLS IN PNIPAAm SCAFFOLDS Open

John M. Heffernan, Sara Bowen, Sabine Borwege, Emily Szeto, James McNamara , et al. · 2016

Glioblastoma (GBM), the most common and lethal classification of primary adult brain tumor, is maintained by a subpopulation of GBM stem-like cells (GSCs) that exhibit a capacity for indefinite self-renewal and are capable of multipotent d…

EXTH-61. NANOPARTICLE DELIVERY TO THE SPINAL CORD VIA DIRECT ADMINISTRATION TO CEREBROSPINAL FLUID Open

Kyle T. Householder, Eugene P. Chung, Justine P. Enns, Rachael W. Sirianni · 2016

Direct delivery of active agents to cerebrospinal fluid (CSF) is one approach used in neuro-oncology for improving drug delivery and activity in the central nervous system; for example, cytarabine-loaded liposomes (DepoCyt©) is a clinicall…

Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1α Open

Caroline P. Addington, S. Dharmawaj, John M. Heffernan, Rachael W. Sirianni, Sarah E. Stabenfeldt · 2016

Enhancing neural stem cell response to SDF-1α gradients through hyaluronic acid-laminin hydrogels Open

Caroline P. Addington, John M. Heffernan, Catherine Susan Millar-Haskell, E W Tucker, Rachael W. Sirianni , et al. · 2015

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