Rachel A. Botting
YOU?
Author Swipe
View article: Author Correction: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Author Correction: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment Open
View article: Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment Open
View article: A prenatal skin atlas reveals immune regulation of human skin morphogenesis
A prenatal skin atlas reveals immune regulation of human skin morphogenesis Open
Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics reference atlas…
View article: Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironment
Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironment Open
Cutaneous T-cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The most common form of CTCL, mycosis fungoides (MF), can be difficult to diagnose resulting in treatment delay. The pathoge…
View article: A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis
A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis Open
Summary Human prenatal skin is populated by innate immune cells including macrophages, and whether they act solely in immunity or have additional functions in morphogenesis is unclear. We assembled the first comprehensive multi-omic refere…
View article: Yolk sac cell atlas reveals multiorgan functions during human early development
Yolk sac cell atlas reveals multiorgan functions during human early development Open
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconc…
View article: Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates Open
View article: Single-cell roadmap of human gonadal development
Single-cell roadmap of human gonadal development Open
Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries 1 . Historically, limited tissue accessibility, a lack of reliable in vitro models and critical differe…
View article: Mapping the developing human immune system across organs
Mapping the developing human immune system across organs Open
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues c…
View article: Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates Open
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances, especially in regenerative medicine, are currently hampered by the lack of knowledge concerning human …
View article: Mapping the developing human immune system across organs
Mapping the developing human immune system across organs Open
Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in unders…
View article: Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2 Open
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet litt…
View article: MultiMAP: dimensionality reduction and integration of multimodal data
MultiMAP: dimensionality reduction and integration of multimodal data Open
View article: Blood and immune development in human fetal bone marrow and Down syndrome
Blood and immune development in human fetal bone marrow and Down syndrome Open
View article: Development of a physiological model of human middle ear epithelium
Development of a physiological model of human middle ear epithelium Open
Introduction Otitis media is an umbrella term for middle ear inflammation; ranging from acute infection to chronic mucosal disease. It is a leading cause of antimicrobial therapy prescriptions and surgery in children. Despite this, treatme…
View article: Cells of the human intestinal tract mapped across space and time.
Cells of the human intestinal tract mapped across space and time. Open
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single…
View article: Cells of the human intestinal tract mapped across space and time
Cells of the human intestinal tract mapped across space and time Open
View article: Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome
Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome Open
Throughout postnatal life, haematopoiesis in the bone marrow (BM) maintains blood and immune cell production. Haematopoiesis first emerges in human BM at 12 post conception weeks while fetal liver (FL) haematopoiesis is still expanding. Ye…
View article: Single-cell roadmap of human gonadal development
Single-cell roadmap of human gonadal development Open
View article: Single-cell multi-omics analysis of the immune response in COVID-19
Single-cell multi-omics analysis of the immune response in COVID-19 Open
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell tr…
View article: Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells Open
View article: Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2 Open
This is the processed data for the manuscript "Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2", https://www.biorxiv.org/content/10.1101/2021.02.17.431591v1
View article: Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2 Open
This is the processed data for the manuscript "Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2", https://www.biorxiv.org/content/10.1101/2021.02.17.431591v1
View article: Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2 Open
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet litt…
View article: MultiMAP: Dimensionality Reduction and Integration of Multimodal Data
MultiMAP: Dimensionality Reduction and Integration of Multimodal Data Open
Multimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, an approach for dimensionality reduction and integration of multiple datasets. MultiMAP recovers a single m…
View article: Developmental cell programs are co-opted in inflammatory skin disease
Developmental cell programs are co-opted in inflammatory skin disease Open
Cellular beauty is skin deep Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, …
View article: The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres
The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres Open
The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well as economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-seq…
View article: Poised cell circuits in human skin are activated in disease
Poised cell circuits in human skin are activated in disease Open
The human skin confers biophysical and immunological protection through a complex cellular network that is established early in development. We profiled ~500,000 single cells using RNA-sequencing from healthy adult and developing skin, and…
View article: Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues
Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues Open
Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. They are the first cells of the immune system to encounter HIV and play a key role in transmission as they deliver the virus to CD4 T cells…
View article: The developing immune network in human prenatal skin
The developing immune network in human prenatal skin Open
Summary Establishment of a well‐functioning immune network in skin is crucial for its barrier function. This begins in utero alongside the structural differentiation and maturation of skin, and continues to expand and diversify across the …