Rachel Blake
YOU?
Author Swipe
Increased Diabetes Complications in a Mouse Model of Oxidative Stress Due to ‘Mismatched’ Mitochondrial DNA Open
Associations between chronic diabetes complications and mitochondrial dysfunction represent a subject of major importance, given the diabetes pandemic and high personal and socioeconomic costs of diabetes and its complications. Modelling d…
View article: The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases Open
Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of i…