Explanipedia

Cannabis Use Motives Associated with Mental Health Screening Among Older Adults Open

Rachel E. Thayer, Juliamaria Coromac-Medrano, Adrianna C. Neiderman · 2025

Cannabis use (CU) motives among older adults (OA) could be an important indicator of broader mental health. OA ages 60+ (N = 78) reported on CU, alcohol consumption, and mood and anxiety. Coping, enhancement, social, conformity, expansion,…

IDENTIFYING GENDER-BASED DIFFERENCES IN CHARACTERISTICS OF OLDER ADULT CANNABIS USERS Open

Juliamaria Coromac-Medrano, Elizabeth Anquillare, Adrianna C. Neiderman, Rachel E. Thayer · 2024

As cannabis use continues to rise among older adults, understanding different patterns of cannabis use is essential for interpreting health outcomes and treatment expectations for this population. This study explored gender differences in …

DOMAIN-SPECIFIC SUBJECTIVE COMPLAINTS AND OBJECTIVE COGNITIVE SCORES IN OLDER ADULT CANNABIS USE Open

Elizabeth Anquillare, Juliamaria Coromac-Medrano, Adrianna Neiderman, Rachel E. Thayer · 2024

Research on the cognitive effects of cannabis among older adults remains sparse and equivocal. Subjective cognitive complaints are predictive of future objective cognitive decline; however, few studies have explored this relationship in ol…

PATTERNS OF USE, RISK FACTORS, AND ATTITUDES OF OLDER ADULT CANNABIS USERS Open

Elizabeth Anquillare, Adrianna Gallegos, Rachel E. Thayer · 2023

While cannabis use continues to increase among older adults (OA), research within this population is limited. This study aimed to describe OA patterns of use, risk factors, and subjective effects of cannabis use. OA cannabis users ages 60-…

84 Preferred Compensatory Cognitive Training Strategies Among Older Adults with Mild Cognitive Difficulties Open

Katie Stypulkowski, Rachel E. Thayer, Elizabeth Anquillare · 2023

Objective: Older adults experiencing mild cognitive difficulties (MCD) may benefit from compensatory cognitive training (CCT) to address cognitive changes. CCT can be delivered over various lengths of time and can focus on a specific cogni…

15 Associations Among Subjective Cognitive Function and Cannabis Use in Older Adults Open

Elizabeth Anquillare, Adrianna C Gallegos, Rachel E. Thayer · 2023

Objective: Cannabis use in older adults is becoming increasingly common as cannabis becomes both more socially acceptable and legally permissible, whether for medical or recreational purposes. While previous research has found harmful effe…

A-109 Perceived Stress and Executive Function in Aging in The Irish Longitudinal Study on Ageing Open

Bailey A Steele, Emily D. Richardson, Rachel E. Thayer, Mark A. Whisman · 2022

Objective: The study was conducted to examine (a) the cross-sectional association between perceived stress (PS) and executive function (EF), accounting for demographic characteristics and depressive symptoms; and (b) age as a moderator of …

A-114 Feasibility of Telehealth Compensatory Cognitive Training for Older Adults with Mild Cognitive Difficulties Open

Katie Stypulkowski, Elizabeth Anquillare, Rachel E. Thayer · 2022

Objective: Older adults (OA) experiencing mild cognitive difficulties (MCD) may benefit from compensatory cognitive training (CCT) to address cognitive changes. CCT is typically delivered in person, which was not possible during the COVID-…

A-100 A Mini-Meta Analysis on Alzheimer’s Disease and Aggression/Agitation Behaviors Open

Adrianna C Gallegos, M D Shields, Gage Singer, Rachel E. Thayer · 2022

Objective: This meta-analysis used primary studies that examined gender differences and behavior disturbances observed in Alzheimer’s disease (ad). Aggression/agitation behaviors become prevalent in advanced cases, with anxiety and problem…

Cannabis Use and Resting State Functional Connectivity in the Aging Brain Open

Karli Watson, Angela D. Bryan, Rachel E. Thayer, Jarrod M. Ellingson, Carillon J. Skrzynski , et al. · 2022

Several lines of evidence suggest that older adults (aged 65+) sharply increased their cannabis use over the last decade, highlighting a need to understand the effects of cannabis in this age group. Pre-clinical models suggest that cannabi…

Long-Term Recreational Cannabis Use Is Associated With Lower Executive Function and Processing Speed in a Pilot Sample of Older Adults Open

Katie Stypulkowski, Rachel E. Thayer · 2021

More older adults are using cannabis for recreational and/or medical purposes, but most studies examining cognitive function and cannabis use do not include older adults. The current small pilot study sought to compare cognitive function a…

A-14 Factors Impacting Long-Term Proactive and Reactive Healthcare Utilization in Cognitively Healthy Older Adults Open

Katie Stypulkowski, Jamie Hansel, Rachel E. Thayer · 2021

Objective Ongoing preventive healthcare is critical to support physical and cognitive health with aging. Several demographic factors have been identified as impacting older adult’s healthcare utilization (HCU), and cognitive training (CT) …

A-25 Factors Predicting Trajectory in Daily Functioning Five Years Post Cognitive Training Open

Jamie Hansel, Rachel E. Thayer · 2021

Objective There is a bidirectional relationship between cognitive functioning and daily functioning. The current study aims to determine factors that are nonmodifiable and modifiable that predict trajectory of daily functioning. Method The…

A-022 Brief Test of Adult Cognition by Telephone to Examine Changes in Cognitive Functioning Open

Jamie Hansel, Jennifer Roberts, Katie Stypulkowski, Rachel E. Thayer · 2020

Objective The purpose of this study was to examine changes in cognitive function over time as measured by a telephone-delivered cognitive assessment. Method Cognitive and biomarker data from the Midlife in the United States (MIDUS) study w…

Recent tobacco use has widespread associations with adolescent white matter microstructure Open

Rachel E. Thayer, Natasha Hansen, Shikha Prashad, Hollis C. Karoly, Francesca M. Filbey , et al. · 2019

P3‐476: REDUCED LOCUS COERULEUS INTEGRITY IS ASSOCIATED WITH POOR ATTENTIONAL CONTROL IN OLDER ADULTS WITHOUT DEMENTIA Open

Alexandra J. Weigand, Rachel E. Thayer, Seraphina K. Solders, Jeremy A. Elman, Tanya Mikhael , et al. · 2019

Stroop test performance declines in pathologic aging, and reaction time intraindividual variability (RT-IIV) on this task may be a sensitive marker of preclinical Alzheimer's disease (AD) as higher IIV connotes a subtle breakdown in attent…

Sexual risk-taking and subcortical brain volume in adolescence Open

Sarah W. Feldstein Ewing, Karen A. Hudson, Justin D. Caouette, Andrew R. Mayer, Rachel E. Thayer , et al. · 2018

These data highlight the potential relevance of subcortical socioemotional processing structures in adolescents' sexual decision-making.

<i>DRD2</i>promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity Open

L. Cinnamon Bidwell, Hollis C. Karoly, Rachel E. Thayer, Eric D. Claus, Angela D. Bryan , et al. · 2018

Studies have identified strong associations between D2 receptor binding potential and neural responses to rewarding stimuli and substance use. Thus, D2 receptor perturbations are central to theoretical models of the pathophysiology of subs…

Neural Correlates of Risky Sex and Response Inhibition in High‐Risk Adolescents Open

Natasha Hansen, Rachel E. Thayer, Sarah W. Feldstein Ewing, Amithrupa Sabbineni, Angela D. Bryan · 2018

Adolescence is a neurodevelopmental period of heightened sexual risk taking. Neuroimaging can help elucidate crucial neurocognitive mechanisms underlying adolescent sexual risk behavior, yet few empirical studies have investigated this neu…

Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents Open

Casey K. Gardiner, Hollis C. Karoly, Rachel E. Thayer, Arielle S. Gillman, Amithrupa Sabbineni , et al. · 2018

Neural activation during delay discounting is cross-sectionally and prospectively associated with risky sexual behavior in adolescence, highlighting a neural basis of risky decision-making as well as opportunities for early identification …

Marijuana Use in an Aging Population: Global Brain Structure and Cognitive Function Open

Rachel E. Thayer · 2018

Scientific literature delineating potential negative impacts or neuroprotective benefits of marijuana consumption has not kept pace with societal changes in acceptance of its recreational use. Further exploration of marijuana use among old…

TLR4 Methylation Moderates the Relationship Between Alcohol Use Severity and Gray Matter Loss Open

Hollis C. Karoly, Rachel E. Thayer, Sarah L. Hagerty, Kent E. Hutchison · 2017

These findings suggest that TLR4 methylation may be protective against the damage conferred by alcohol on precuneus and inferior parietal gray matter, thereby implicating TLR4 for further investigation as a possible AUD treatment target.

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults Open

Rachel E. Thayer, Sophie L. YorkWilliams, Hollis C. Karoly, Amithrupa Sabbineni, Sarah Feldstein Ewing , et al. · 2017

Background and Aims Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study …

Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry Open

Rachel E. Thayer, Sarah L. Hagerty, Amithrupa Sabbineni, Eric D. Claus, Kent E. Hutchison , et al. · 2016

Chronic alcohol use is associated with declines in gray matter (GM) volume, as is the normal aging process. Less apparent, however, is how the interaction between aging and heavy alcohol use affects changes in GM across the lifespan. There…

Developmental Cognitive Neuroscience of Adolescent Sexual Risk and Alcohol Use Open

Sarah W. Feldstein Ewing, Sephira G. Ryman, Arielle S. Gillman, Barbara J. Weiland, Rachel E. Thayer , et al. · 2015

Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults Open

Barbara J. Weiland, Rachel E. Thayer, Brendan E. Depue, Amithrupa Sabbineni, Angela D. Bryan , et al. · 2015

Recent research has suggested that marijuana use is associated with volumetric and shape differences in subcortical structures, including the nucleus accumbens and amygdala, in a dose-dependent fashion. Replication of such results in well …

Importance of construct validity in functional neuroimaging of craving Open

Rachel E. Thayer, Barbara J. Weiland · 2015

Sayette & Wilson 1 raise a number of important considerations for functional neuroimaging of drug craving, particularly whether existing studies accurately capture construct validity of craving as a strong desire or urge to use. Intensity …

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