Rachel E. Walker
YOU?
Author Swipe
Relationship between oxygenated fatty acid and milk fat concentration during diet-induced milk fat depression in dairy cows Open
Altered rumen biohydrogenation of UFA is central to the current understanding of diet-induced milk fat depression (MFD) in dairy cows, and associations with numerous trans fatty acids (FA) have been characterized. Although some specific CL…
Maternal Complications of Pregnancy and Achievement of Secretory Activation and Coming to Volume in Breast Pump-Dependent Mothers of Preterm Infants Open
Objective: Mother's own milk (MOM) sodium (Na) is an objective measure of secretory activation (SA), which is often delayed or impaired after preterm delivery. We sought to determine in pump-dependent mothers of preterm infants, impacts of…
Integrating Biological, Behavioral, and Economic Factors in the Practice and Study of Early, Unplanned Lactation Cessation Open
Background: An estimated 60% of mothers experience early, unplanned lactation cessation and do not meet their breastfeeding goals, increasing the risk of maternal and infant health problems and their associated costs. Perceived or real ins…
Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: A systematic review and meta‐analysis Open
Background Gestational diabetes mellitus (GDM) can result in increased placental lesions related to high maternal blood glucose, but these relationships are not well understood. Objective To examine the relationship between GDM and placent…
Gestational diabetes mellitus and vascular malperfusion lesions in the placenta: a systematic review and meta-analysis Open
Background Gestational diabetes mellitus (GDM) can result in increased placental lesions related to high maternal blood glucose, but these relationships are not well understood. Objective To examine the relationship between GDM and placent…
The effect of late gestation injectable vitamin A and D supplementation on sow and piglet performance Open
Vitamin A is an essential nutrient with an important role in animal health across livestock species. Insufficient dietary vitamin A intake is associated with decreased reproductive performance in females as well as impaired growth performa…
Assessment of reproductive challenges and nutritional practices on Pennsylvania sow farms Open
Pennsylvania is ranked 12th in the United States of America in pork production and hosts a diverse population of farms of different herd sizes, management techniques, and reproductive issues. Despite the appreciation of this diversity, the…
Iron status and anemia in a representative sample of US pregnant women is not associated with pre-pregnancy BMI: Results from the NHANES (1999–2010) study Open
Iron deficiency in pregnancy is related to many poor health outcomes, including anemia and low birth weight. A small number of previous studies have identified maternal body mass index (BMI) as a potential risk factor for poor iron status.…
ABCA1 and apoA-I dependent 12-hydroxyeicosatetraenoic acid efflux regulates macrophage inflammatory signaling Open
Aberrant high-density lipoprotein (HDL) function is implicated in inflammation-associated pathologies. While HDL ABCA1-mediated reverse cholesterol and phospholipid transport are well described, the movement of pro-/anti-inflammatory lipid…
Prevalence of Non-exclusive Breastfeeding in the Context of Vitamin D Supplementation During Pregnancy and Lactation in Bangladesh Open
Objectives: Vitamin D deficiency is a global health issue and may impact milk supply through modulating mammary inflammation and lipid metabolism. However, data is limited on the role of vitamin D in lactation outcomes. We aimed to examine…
PSIII-10 Impact of late gestation vitamin A and D injection on offspring growth and immune parameters in piglets Open
Supranutritional use of vitamins may have an impact on mortality rates of sows and piglets. Specifically, injection of vitamin A, and vitamin A and D (VitAD) has improved subsequent preweaning mortality when given to sows after weaning and…
Iron status in a representative sample of US pregnant women is not associated with pre-pregnancy BMI: results from the NHANES (1999-2010) study Open
Iron deficiency in pregnancy is related to many poor health outcomes, including anemia and low birth weight. A small number of previous studies have identified maternal body mass index (BMI) as potential risk factors for poor iron status. …
View article: Maternal Vitamin B12 in Pregnancy and Placental Development
Maternal Vitamin B12 in Pregnancy and Placental Development Open
Vitamin B12, or cobalamin, is an essential nutrient required for diverse physiological functions secondary to its role as a critical cofactor for two mammalian enzymes, methionine synthase and methylmalonyl‐CoA mutase. While essential thro…
Esterified Oxylipins: Do They Matter? Open
Oxylipins are oxygenated metabolites of fatty acids that share several similar biochemical characteristics and functions to fatty acids including transport and trafficking. Oxylipins are most commonly measured in the non-esterified form wh…
Oxylipins as Potential Regulators of Inflammatory Conditions of Human Lactation Open
Chronic low-grade inflammation can be associated with obesity or subclinical mastitis (SCM), which is associated with poor infant growth in low- to middle-income country settings. It is unknown what physiological mechanisms are involved in…
Fatty Acid Transfer from Blood to Milk Is Disrupted in Mothers with Low Milk Production, Obesity, and Inflammation Open
Mothers with very low milk production have significantly higher obesity and inflammatory biomarkers, lower LCFAs in milk, and disrupted association between plasma and milk LCFAs. These data support the hypothesis that inflammation disrupts…
Metabolites milk oxylipin data Open
Data used to assess quality of milk oxylipin measurements.
Chronic Elevation of Tumor Necrosis Factor-Alpha Suppresses Lactation via Downregulation of Lipoprotein Lipase Open
OBJECTIVES: Identification of physiologic factors that impede lactation is critical for developing interventions to support milk production. Our objective was to examine the role of tumor necrosis factor–alpha (TNF-A), a potent regulator o…
View article: Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload Open
Aims Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous medium-/long-chain fatty acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in the heart is unclear. Given its put…
Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low‐density lipoproteins in isolated perfused rat livers Open
Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis. Very low-density lipoproteins (VLDL) contain oxylipins, but it is unknow…
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia Open
In adipose, insulin functions to suppress intracellular lipolysis and secretion of nonesterified fatty acid (NEFA) into plasma. We applied glucose and NEFA minimal models (MM) following a frequently sampled intravenous glucose tolerance te…
View article: Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis
Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis Open
Background Non-resolving activation of immune responses is central to the pathogenesis of heart failure (HF). Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor (GPR) for medium-and long-chain fatty acids (FA) that regulat…