Regina Cheuk‐Lam Lo
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View article: Multiple 11C-acetate and 18fludeoxyglucose-avid hepatic tumours in a young woman: primary, secondary, or something else?
Multiple 11C-acetate and 18fludeoxyglucose-avid hepatic tumours in a young woman: primary, secondary, or something else? Open
A 32-year-old lady presented with abdominal pain and computed tomography scan detected multifocal bilobar hepatic tumours. The tumours had heterogeneous radiological appearance. The largest tumour situated in left lateral section and was h…
View article: Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression
Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression Open
Background: Extracellular matrix proteins are tightly linked to cancer progression. HCC frequently arises from chronic liver diseases with varying degrees of parenchymal fibrosis. Herein, we aimed to investigate the roles of secreted lumic…
View article: Efficacy of systemic therapy for advanced hepatocellular carcinoma based on etiology: A systematic review and network meta-analysis of randomized phase III trials
Efficacy of systemic therapy for advanced hepatocellular carcinoma based on etiology: A systematic review and network meta-analysis of randomized phase III trials Open
Treatment efficacy of advanced HCC is affected by underlying liver disease. The survival benefit of ICI + VEGF/VEGFRi was mainly seen in viral-HCC.
View article: Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification
Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification Open
Current therapies show limited efficacy for advanced hepatocellular carcinoma (HCC). This study demonstrates that targeting the mevalonate pathway induces ferroptosis in HCC by disrupting CoQ10 biosynthesis and selenoprotein translation. C…
View article: Small Extracellular Vesicle‐Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl‐Coenzyme A Synthetase SLC27A4‐Mediated Glycolysis to Promote Hepatocellular Carcinoma
Small Extracellular Vesicle‐Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl‐Coenzyme A Synthetase SLC27A4‐Mediated Glycolysis to Promote Hepatocellular Carcinoma Open
Tumour‐derived small extracellular vesicles (sEV) are critical mediators within the tumour microenvironment (TME) and are known to regulate various metabolic pathways. In metastatic hepatocellular carcinoma (HCC), mass spectrometry protein…
View article: Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson's Disease Patients
Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson's Disease Patients Open
View article: Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology Open
Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.
View article: Implementing Aging in Place in Hong Kong: Meeting the Needs and Aspirations of Older Adults and Their Caregivers Living in Private Housing
Implementing Aging in Place in Hong Kong: Meeting the Needs and Aspirations of Older Adults and Their Caregivers Living in Private Housing Open
A policy of aging in place should be accompanied by physical and social environments that support healthy aging. This article describes how a property development company in Hong Kong sought to elicit the views of older people and their ca…
View article: Closing the loop – the role of pathologists in digital and computational pathology research
Closing the loop – the role of pathologists in digital and computational pathology research Open
An increasing number of manuscripts related to digital and computational pathology are being submitted to The Journal of Pathology: Clinical Research as part of the continuous evolution from digital imaging and algorithm‐based digital path…
View article: Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma
Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma Open
View article: Penggunaan Bahasa Pemrograman Python dalam Menganalisis Hubungan Kualitas Kopi dengan Lokasi Pertanian Kopi
Penggunaan Bahasa Pemrograman Python dalam Menganalisis Hubungan Kualitas Kopi dengan Lokasi Pertanian Kopi Open
Coffee is a drink that everyone loves, however, not all coffee consumed has good quality. The quality of coffee is influenced by various factors, one of which is the location of the farm. Therefore, it is very important to analyze the rela…
View article: Healthy Ageing Should Be a Key Component of Ageing in Place: Case Study from Hong Kong
Healthy Ageing Should Be a Key Component of Ageing in Place: Case Study from Hong Kong Open
As part of a knowledge-transfer project consisting of a series of three talks on the topic of healthy ageing and ageing in place, we explored what participants (older adults, students, the general public, as well as professionals in archit…
View article: Supplementary Table S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S3. Up-stream regulator of IGF2.
View article: Supplementary Table S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S1. Differentially expressed genes identified in HBx-B Mut tumours against peripheral normal tissues.
View article: Supplementary Figure S4 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S4 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S4. Serum metabolite profiles of experimental animals.
View article: Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S2. KEGG canonical signaling pathways and metabolic pathways.
View article: Supplementary Figure S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S1. In vivo and in vitro experimental approaches.
View article: Supplementary Table S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S1. Differentially expressed genes identified in HBx-B Mut tumours against peripheral normal tissues.
View article: Supplementary Figure S4 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S4 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S4. Serum metabolite profiles of experimental animals.
View article: Data from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Data from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind this remain unclear. This study elucidated the mechanisms contributing to tumor dev…
View article: Supplementary materials and methods from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary materials and methods from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary materials and methods for PCR and serum preparation.
View article: Supplementary Figure S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S3. RNA sequencing result of HBx-B Mut tumours against peripheral normal tissues.
View article: Supplementary Table S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S3. Up-stream regulator of IGF2.
View article: Supplementary Figure S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S2. IHC staining of FAH, P53, pAKT and CTNNB1.
View article: Supplementary materials and methods from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary materials and methods from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary materials and methods for PCR and serum preparation.
View article: Supplementary Figure S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S1 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S1. In vivo and in vitro experimental approaches.
View article: Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Table S2. KEGG canonical signaling pathways and metabolic pathways.
View article: Supplementary Figure S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S2. IHC staining of FAH, P53, pAKT and CTNNB1.
View article: Supplementary Figure S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Supplementary Figure S3 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Supplementary Figure S3. RNA sequencing result of HBx-B Mut tumours against peripheral normal tissues.
View article: Data from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
Data from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism Open
Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the genetic mechanisms behind this remain unclear. This study elucidated the mechanisms contributing to tumor dev…