Ravi Yadav
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View article: Clinical, Radiological and Therapeutic Profile of Patients With DYT- <i>TOR1A</i> from a single tertiary care centre in India, with a literature review of the MDSGene Asian cohort
Clinical, Radiological and Therapeutic Profile of Patients With DYT- <i>TOR1A</i> from a single tertiary care centre in India, with a literature review of the MDSGene Asian cohort Open
This Indian patient cohort shows a strong male predominance and a consistent early involvement of the upper limbs. A shorter duration of illness with greater severity highlights the need for early recognition and potential surgical interve…
View article: A comparison of nonmotor symptom profiles in Progressive supranuclear palsy and Parkinson’s disease
A comparison of nonmotor symptom profiles in Progressive supranuclear palsy and Parkinson’s disease Open
INTRODUCTION: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that affects movement, gait, balance, speech, and swallowing. Nonmotor symptoms (NMSs) are well recognized in atypical parkinsonism. However, owing to the r…
View article: Community-based nursing strategies for optimizing public health outcomes: a systematic review and meta-analysis
Community-based nursing strategies for optimizing public health outcomes: a systematic review and meta-analysis Open
View article: CLCN2-Related Leukoencephalopathy Presenting as Isolated Paroxysmal Non-Kinesigenic Dyskinesia: Clinical, Imaging, and Genetic Correlation
CLCN2-Related Leukoencephalopathy Presenting as Isolated Paroxysmal Non-Kinesigenic Dyskinesia: Clinical, Imaging, and Genetic Correlation Open
View article: Congenital ataxic phenotype of <i>ITPR1</i> -related disorder due to novel missense variants – A video case series
Congenital ataxic phenotype of <i>ITPR1</i> -related disorder due to novel missense variants – A video case series Open
View article: Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease
Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease Open
Parkinson's disease (PD) is characterized by chronic neuroinflammation and peripheral immune dysfunction, yet the mechanisms underlying systemic-immunomodulatory failure remain unclear. Here we demonstrate that mesenchymal stromal cell (MS…
View article: Whole-genome sequencing of 197 cases with Parkinson’s Disease reveals novel pathogenic variants in the Indian population
Whole-genome sequencing of 197 cases with Parkinson’s Disease reveals novel pathogenic variants in the Indian population Open
Background Most genetic studies of Parkinson’s disease (PD) have been performed in European cohorts, and large-scale studies in Indian populations are lacking. Consequently, many variants common in Europeans are rare or absent in Indian pa…
View article: Generation of induced pluripotent stem cells (NIMHi018-A) from a Parkinson’s disease patient harbouring a heterozygous missense mutation for PINK1 variant c.1208G > A, p.Trp403Ter
Generation of induced pluripotent stem cells (NIMHi018-A) from a Parkinson’s disease patient harbouring a heterozygous missense mutation for PINK1 variant c.1208G > A, p.Trp403Ter Open
The PTEN-induced kinase 1 (PINK1) gene mutation is the second most prevalent young-onset Parkinson disease (YOPD) characterized by early onset of motor symptoms that are often indistinguishable from other causes of PD. Induced pluripotent …
View article: The Landscape of Parkinson’s Disease Treatment in India: A National Cross-Sectional Survey of Clinical Practitioners
The Landscape of Parkinson’s Disease Treatment in India: A National Cross-Sectional Survey of Clinical Practitioners Open
View article: Ayurveda therapeutic regimen as an Add-on to optimized conventional management of Parkinson’s disease: Protocol for an exploratory RCT for assessment of Clinical, Cortical excitability, Neuroimmune and Autonomic function parameters (Preprint)
Ayurveda therapeutic regimen as an Add-on to optimized conventional management of Parkinson’s disease: Protocol for an exploratory RCT for assessment of Clinical, Cortical excitability, Neuroimmune and Autonomic function parameters (Preprint) Open
BACKGROUND Parkinson's disease (PD), a progressive neurodegenerative disorder, lacks disease-modifying treatments. Current therapies focus on symptomatic relief, highlighting the need for adjunctive neuroprotective strategies. Ayurveda, a…
View article: Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker?
Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker? Open
View article: Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease
Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease Open
Introduction Parkinson's Disease (PD) features debilitating motor symptoms, particularly gait and balance impairments inadequately managed by current therapies. Bassoon (BSN), a presynaptic active zone organizer, has been implicated in var…
View article: Anti-IgLON5-Related Movement Disorders: A Series of Three Cases from a Tertiary Centre in India
Anti-IgLON5-Related Movement Disorders: A Series of Three Cases from a Tertiary Centre in India Open
View article: Rescue Right Pallidotomy and Left Thalamotomy in a patient with <i>PLA2G6</i> -associated Refractory Status Dystonicus and Tremor
Rescue Right Pallidotomy and Left Thalamotomy in a patient with <i>PLA2G6</i> -associated Refractory Status Dystonicus and Tremor Open
View article: Spinocerebellar ataxia type 2 presenting as complex hyperkinetic movement disorder with a dramatic response to anticholinergic therapy
Spinocerebellar ataxia type 2 presenting as complex hyperkinetic movement disorder with a dramatic response to anticholinergic therapy Open
View article: Delayed presentation of Diencephalic-Mesencephalic Junction Dysplasia with Compulsive truncal movements and Blepharospasm: A Case Report from India
Delayed presentation of Diencephalic-Mesencephalic Junction Dysplasia with Compulsive truncal movements and Blepharospasm: A Case Report from India Open
View article: Predictors of Impulse Control Disorders in Patients with Parkinson’s Disease
Predictors of Impulse Control Disorders in Patients with Parkinson’s Disease Open
View article: Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study
Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open
Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…
View article: Long-Term Effects of Deep Brain Stimulation on Non-Motor Symptoms in Patients with Parkinson’s Disease
Long-Term Effects of Deep Brain Stimulation on Non-Motor Symptoms in Patients with Parkinson’s Disease Open
Background and Objectives: Deep brain stimulation (DBS) is an approved treatment modality for Parkinson’s disease (PD) with significant improvement in motor symptoms. We aimed to study the long-term effects of DBS on non-motor symptoms (NM…
View article: Development and internal validation of clinical prediction models for scrub typhus and doxycycline-treatable causes in paediatric acute encephalitis syndrome in Karnataka, India: a multicentre, prospective study
Development and internal validation of clinical prediction models for scrub typhus and doxycycline-treatable causes in paediatric acute encephalitis syndrome in Karnataka, India: a multicentre, prospective study Open
View article: Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population
Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population Open
Background Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions a…
View article: Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice Open
View article: Diagnostic Spectrum in an “Atypical” Atypical Parkinsonism Syndrome Cohort: A Single Center Experience
Diagnostic Spectrum in an “Atypical” Atypical Parkinsonism Syndrome Cohort: A Single Center Experience Open
View article: Comparative Analysis of Fat Sources in Infant Formulas and Their Metabolic Consequences in the Development of Non-Alcoholic Fatty Liver Disease in a Pediatric Pig Model
Comparative Analysis of Fat Sources in Infant Formulas and Their Metabolic Consequences in the Development of Non-Alcoholic Fatty Liver Disease in a Pediatric Pig Model Open
View article: Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference Open
Recent years have seen major advances in tau‐associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the…
View article: Tuberculosis Related Movement Disorders: A Systematic Scoping Review Highlighting Geographic Disparities, Phenotypic Patterns, Treatment Responses, and Knowledge Gaps in Global Reporting
Tuberculosis Related Movement Disorders: A Systematic Scoping Review Highlighting Geographic Disparities, Phenotypic Patterns, Treatment Responses, and Knowledge Gaps in Global Reporting Open
Background Tuberculosis (TB) of the central nervous system (CNS) is a severe complication of TB, with movement disorders representing an under‐recognized yet impactful manifestation. Despite their clinical significance, knowledge gaps pers…
View article: Altered Cortical Excitability and Inhibition in Patients with Primary Dystonia: A Transcranial Magnetic Stimulation Study
Altered Cortical Excitability and Inhibition in Patients with Primary Dystonia: A Transcranial Magnetic Stimulation Study Open
Background: The literature on cortical excitability, inhibitory and facilitatory properties of the brain in patients with primary dystonia is not well elucidated. We aimed to study the changes in these neurophysiological parameters in pati…
View article: Allelic Diversity, de novo CAG Expansions, and Intergenerational Instability at the HTT Locus in a clinical sample of Huntington’s Disease from India
Allelic Diversity, de novo CAG Expansions, and Intergenerational Instability at the HTT Locus in a clinical sample of Huntington’s Disease from India Open
BACKGROUND Huntington’s disease (HD) is an inherited, neurodegenerative disorder, caused by the expansion of an unstable CAG repeat sequence in the HTT gene. The prevalence of HD, allelic diversity, rate of novel expansions, and the clinic…
View article: Utility of Sleep Questionnaires for Detecting Sleep Apnea in Ischemic Stroke Patients
Utility of Sleep Questionnaires for Detecting Sleep Apnea in Ischemic Stroke Patients Open
Background and Objectives: Sleep-disordered breathing is highly prevalent in stroke patients. It is associated with recurrence of stroke and poor neurologic outcomes. Polysomnography (PSG), the gold standard for diagnosing sleep apnea, may…
View article: Deciphering the Genetic Architecture of Parkinson’s Disease in India
Deciphering the Genetic Architecture of Parkinson’s Disease in India Open
The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…