Rada Mišković
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View article: PR3-ANCA Positive Behçet’s Disease with Severe Multisystem Involvement: A Diagnostic Challenge
PR3-ANCA Positive Behçet’s Disease with Severe Multisystem Involvement: A Diagnostic Challenge Open
Background: Behçet’s disease (BD) and granulomatosis with polyangiitis (GPA) are distinct vasculitides. PR3-ANCA is considered specific for GPA, yet rare BD cases demonstrate positivity, creating diagnostic dilemmas. Case Presentation: We …
View article: Antineutrophil Cytoplasmic Autoantibodies Specific to Bactericidal/Permeability-Increasing Protein: A Cross-Road Between Prolonged Gram-Negative Bacterial Infections and Ulcerative Colitis/Primary Sclerosing Cholangitis
Antineutrophil Cytoplasmic Autoantibodies Specific to Bactericidal/Permeability-Increasing Protein: A Cross-Road Between Prolonged Gram-Negative Bacterial Infections and Ulcerative Colitis/Primary Sclerosing Cholangitis Open
Background/Objectives: Binding of bactericidal/permeability-increasing (BPI) protein to Gram-negative (GN) bacteria plays a major role in bacterial elimination. The relationship between BPI-antineutrophil cytoplasmic autoantibodies (ANCA),…
View article: Life-Threatening Macrophage Activation Syndrome in Pregnancy: First Manifestation of SLE Induced by Parvovirus B19
Life-Threatening Macrophage Activation Syndrome in Pregnancy: First Manifestation of SLE Induced by Parvovirus B19 Open
Macrophage activation syndrome (MAS) is a complex, life-threatening, hyperinflammatory condition occurring as a form of hemophagocytic lymphohistiocytosis (HLH), commonly associated with several autoimmune and autoinflammatory diseases, an…
View article: DIAGNOSTIC AND THERAPEUTIC CHALLENGES IN ELDERLY-ONSET SJÖGREN’S SYNDROME
DIAGNOSTIC AND THERAPEUTIC CHALLENGES IN ELDERLY-ONSET SJÖGREN’S SYNDROME Open
Recent research indicates that the age of disease onset plays a crucial role in shaping the phenotype of systemic autoimmune inflammatory diseases. Late-onset Sjögren’s syndrome (SS) presents unique diagnostic challenges due to symptom ove…
View article: Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review
Successful Desensitization to Sorafenib and Imatinib—A Report of Two Cases and a Literature Review Open
Background: Drug desensitization allows for safe administration of a drug to a patient with a previous hypersensitivity reaction. Successful desensitization protocols have been described for different medications, including protocols for o…
View article: Case report: Rapidly progressive neurocognitive disorder with a fatal outcome in a patient with PU.1 mutated agammaglobulinemia
Case report: Rapidly progressive neurocognitive disorder with a fatal outcome in a patient with PU.1 mutated agammaglobulinemia Open
Introduction PU.1-mutated agammaglobulinemia (PU.MA) represents a recently described autosomal-dominant form of agammaglobulinemia caused by mutation of the SPI1 gene. This gene codes for PU.1 pioneer transcription factor important for the…
View article: Asthma Inflammatory Phenotypes: How Can We Distinguish Them?
Asthma Inflammatory Phenotypes: How Can We Distinguish Them? Open
Background and objectives: induced sputum is used to assess different inflammatory phenotypes in asthma, but is not used routinely. We aimed to determine the proportion of inflammatory asthma phenotypes based on induced sputum, to find bio…
View article: Kounis syndrome as a cause of acute coronary syndrome
Kounis syndrome as a cause of acute coronary syndrome Open
Introduction. Kounis syndrome (KS) represents an acute coronary syndrome (ACS) induced by a hypersensitivity reaction. First described by Kounis and Zavras in 1991, KS today represents an infrequently diagnosed clinical syndrome. Three dif…
View article: Epstein-Barr virus infection as potential indicator of the occurrence and clinical presentation of systemic lupus erythematosus
Epstein-Barr virus infection as potential indicator of the occurrence and clinical presentation of systemic lupus erythematosus Open
Introduction The relationship between Systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection has been suggested for decades, but the underlying mechanism of the EBV influence on SLE development remains to be elucidated. …
View article: Myositis-specific autoantibodies in a non-traveler, patient from a non-endemic country, with Plasmodium vivax malaria
Myositis-specific autoantibodies in a non-traveler, patient from a non-endemic country, with Plasmodium vivax malaria Open
Introduction: Autoantibodies (AAb) are a hallmark of immune-mediated inflammatory diseases. Malaria is a parasitic disease caused by Plasmodium protozoa. Individuals with malaria may present with a wide range of symptoms. It is frequently …
View article: Uncovering the Role of Epstein–Barr Virus Infection Markers for Remission in Rheumatoid Arthritis
Uncovering the Role of Epstein–Barr Virus Infection Markers for Remission in Rheumatoid Arthritis Open
Epstein–Barr virus (EBV) infection has been shown as a potential risk factor for the development of rheumatoid arthritis (RA). This prospective research aimed to investigate whether EBV infection markers changed during the six-month follow…
View article: Markers of Epstein–Barr Virus Infection in Association with the Onset and Poor Control of Rheumatoid Arthritis: A Prospective Cohort Study
Markers of Epstein–Barr Virus Infection in Association with the Onset and Poor Control of Rheumatoid Arthritis: A Prospective Cohort Study Open
Although the connection between Epstein–Barr virus (EBV) and rheumatoid arthritis (RA) has been studied for over 40 years, many questions still need clarification. The study aimed to analyze the possible association between anti-EBV antibo…
View article: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE
Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE Open
Systemic lupus erythematosus (SLE) is characterized by an imbalance between proinflammatory and anti-inflammatory mediators. Single-nucleotide polymorphisms (SNPs) in genes coding IL10RA, IL10RB, and IL22RA could affect their expression or…
View article: Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review
Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review Open
Introduction Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a…
View article: Epstein–Barr Virus Reactivation as a New Predictor of Achieving Remission or Lupus Low Disease Activity State in Patients with Systemic Lupus Erythematosus with Cutaneous Involvement
Epstein–Barr Virus Reactivation as a New Predictor of Achieving Remission or Lupus Low Disease Activity State in Patients with Systemic Lupus Erythematosus with Cutaneous Involvement Open
Although Epstein–Barr virus (EBV) reactivation has long been associated with the pathogenesis of systemic lupus erythematosus (SLE), many aspects of this relationship remain unclear. Our objective was to investigate the association between…
View article: SARS-CoV-2–associated myopathy with positive anti–Mi-2 antibodies: a case report
SARS-CoV-2–associated myopathy with positive anti–Mi-2 antibodies: a case report Open
of the University Clinical Centre of Serbia in August 2020 with bilateral weakness and aches in the proximal muscles of the upper and lower extremities, limited limb movement, and poor tolerance of physical exertion.Symptoms had developed …
View article: Large-Vessel Giant Cell Arteritis following COVID-19—What Can HLA Typing Reveal?
Large-Vessel Giant Cell Arteritis following COVID-19—What Can HLA Typing Reveal? Open
Giant cell arteritis (GCA) is an immune-mediated vasculitis that affects large arteries. It has been hypothesized that viruses may trigger inflammation within the vessel walls. Genetic studies on human leukocyte antigens (HLAs) have previo…
View article: Neuropsychiatric lupus: Two faces of one disease (two case reports)
Neuropsychiatric lupus: Two faces of one disease (two case reports) Open
Introduction: Neuropsychiatric lupus (neuropsychiatric systemic lupus erythematosus - NPSLE) is a form of a systemic autoimmune disease - systemic lupus erythematosus (SLE), with dominant central and peripheral nervous system involvement. …
View article: The role of Epstein-Barr virus in systemic lupus erythematosus
The role of Epstein-Barr virus in systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease that develops in a complex interaction of genetic and environmental factors. Viruses have long been recognized as important factors in the pathogenesis of lup…
View article: Epstein–Barr virus positive gastric adenocarcinoma with systemic EBV reactivation in a patient with persistently active systemic lupus erythematosus
Epstein–Barr virus positive gastric adenocarcinoma with systemic EBV reactivation in a patient with persistently active systemic lupus erythematosus Open
Objectives Epstein–Barr virus (EBV) has been associated with several types of cancers, most often with nasopharyngeal carcinomas and hematological malignancies. It is also suggested that EBV has significant role in the pathogenesis of diff…
View article: Autoimmune and immunoserological markers of COVID-19 pneumonia: Can they help in the assessment of disease severity
Autoimmune and immunoserological markers of COVID-19 pneumonia: Can they help in the assessment of disease severity Open
Background Immune dysregulation and associated inefficient anti-viral immunity during Coronavirus Disease 2019 (COVID-19) can cause tissue and organ damage which shares many similarities with pathogenetic processes in systemic autoimmune d…
View article: Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study
Enhanced Liver Fibrosis Score as a Biomarker for Vascular Damage Assessment in Patients with Takayasu Arteritis—A Pilot Study Open
Takayasu Arteritis (TA) is characterized by granulomatous panarteritis, vessel wall fibrosis, and irreversible vascular impairment. The aim of this study is to explore the usefulness of the Enhanced Liver Fibrosis score (ELF), procollagen-…
View article: Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis
Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis Open
Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demo…
View article: Biomarkers of disease activity in patients with chronicspontaneous urticaria
Biomarkers of disease activity in patients with chronicspontaneous urticaria Open
CRP, D-dimer, and PT may be considered as biomarkers for distinguishing patients with CSU from controls. The C4 levels correlate with disease activity and may be useful as a potential biomarker of disease activity.
View article: 114. A RARE ASSOCIATION OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS AND HCV INFECTION
114. A RARE ASSOCIATION OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS AND HCV INFECTION Open
EGPA SE 55.9 81.3 97,4 50.0 90.0 SP 71.4 85.7 81.1 98.9 94.4 PPV 70.2 87.2 74.5 83.3 90.0 NPV 57.3 79.2 98,2 95.1 98.9 PLR 1.9 5.6 45.1 49 88.2 NLR 0.6 0,2 0,03 0.5 0,1 Accuracy 62.9 83.3 87.0 94.4 98.1 SE¼ sensitivity, SP¼ specificity, PP…