Radhika Joshi
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View article: Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse
Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse Open
Aging and alcohol misuse are linked to immune dysfunction, systemic inflammation, and altered innate immune responses. Here, we examined monocyte/macrophage responses in the liver, brain, and bone marrow of young and aged mice under alcoho…
View article: Author response: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube
Author response: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube Open
View article: Author response: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube
Author response: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube Open
View article: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube
Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube Open
The apical extracellular matrix (aECM) plays a critical role in epithelial tube morphogenesis during organ formation, but its composition and organization remain poorly understood. Using the Drosophila embryonic salivary gland (SG) as a mo…
View article: Organization of the apical extracellular matrix during tubular organ formation
Organization of the apical extracellular matrix during tubular organ formation Open
The apical extracellular matrix (aECM) plays a critical role in epithelial tube morphogenesis during organ formation, but its composition and organization remain poorly understood. Using the Drosophila embryonic salivary gland (SG) as a mo…
View article: Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube
Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube Open
The apical extracellular matrix (aECM) plays a critical role in epithelial tube morphogenesis during organ formation, but its composition and organization remain poorly understood. Using the Drosophila embryonic salivary gland (SG) as a mo…
View article: Author response: Organization of the apical extracellular matrix during tubular organ formation
Author response: Organization of the apical extracellular matrix during tubular organ formation Open
View article: Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation
Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation Open
View article: Phenotypic and genetic characterization of Halari donkey of Gujarat
Phenotypic and genetic characterization of Halari donkey of Gujarat Open
Halari donkey have a habitat of Halar and adjoining regions includes Jamnagar, Surendranagar and Devbhumi Dwarka districts of Gujarat. On the basis of phenotypic and molecular characterization, it got registration as a new breed of donkey …
View article: Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF
Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF Open
Background Gasdermin D (GSDM-D), a key executor of pyroptosis, is increased in various liver diseases and contributes to disease progression. Alcohol induces inflammasome activation and cell death, which are both linked to GSDM-D activatio…
View article: A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition
A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition Open
View article: Sulfation affects apical extracellular matrix organization during development of the <i>Drosophila</i> embryonic salivary gland tube
Sulfation affects apical extracellular matrix organization during development of the <i>Drosophila</i> embryonic salivary gland tube Open
The apical extracellular matrix (aECM) plays a critical role in epithelial tube morphogenesis during organ formation, but its composition and organization remain poorly understood. Using the Drosophila embryonic salivary gland (SG) as a mo…
View article: IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease
IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease Open
View article: In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis
In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis Open
Severe alcohol-associated hepatitis (AH) is a life-threatening form of alcohol-associated liver disease. Liver neutrophil infiltration is a hallmark of AH, yet the effects of alcohol on neutrophil functions remain elusive. Identifying ther…
View article: Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis Open
Objective Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism through which repeated alcohol binges exacerb…
View article: IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease
IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease Open
Summary The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF…
View article: G-CSF increases calprotectin expression, liver damage and neuroinflammation in a murine model of alcohol-induced ACLF
G-CSF increases calprotectin expression, liver damage and neuroinflammation in a murine model of alcohol-induced ACLF Open
Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induce…
View article: Bile acid–induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1
Bile acid–induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1 Open
Background and Aims: Cell death and inflammation play critical roles in chronic tissue damage caused by cholestatic liver injury leading to fibrosis and cirrhosis. Liver cirrhosis is often associated with kidney damage, which is a severe c…
View article: Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease
Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease Open
Alcohol use disorder is associated with systemic inflammation and organ dysfunction especially in the liver and the brain. For more than a decade, studies have highlighted alcohol abuse-mediated impairment of brain function and acceleratio…
View article: Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice
Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice Open
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival …
View article: PERIOD Phosphoclusters Control Temperature Compensation of the Drosophila Circadian Clock
PERIOD Phosphoclusters Control Temperature Compensation of the Drosophila Circadian Clock Open
Ambient temperature varies constantly. However, the period of circadian pacemakers is remarkably stable over a wide-range of ecologically- and physiologically-relevant temperatures, even though the kinetics of most biochemical reactions ac…
View article: PERIOD phosphoclusters control temperature compensation of the <i>Drosophila</i> circadian clock
PERIOD phosphoclusters control temperature compensation of the <i>Drosophila</i> circadian clock Open
Temperature compensation is a critical feature of circadian rhythms, but how it is achieved remains elusive. Here, we uncovered the important role played by the Drosophila PERIOD (PER) phosphodegron in temperature compensation. Using CRISP…
View article: Secretory mouse quiescin sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in vivo
Secretory mouse quiescin sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in vivo Open
View article: Phenotypic characterization of Dagri cattle of Gujarat
Phenotypic characterization of Dagri cattle of Gujarat Open
A hill cattle population locally known as Dagri reared by tribals from eastern border districts of Gujarat adjoiningto Madhya Pradesh and Rajasthan, mainly Dahod and Chhotaudepur and to some extent Panchmahal, Mahisagarand Narmada was inve…
View article: Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing
Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing Open
The Drosophila circadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and post-translational regulation. While post-translational regulatory mechanisms have been studied in detail, much less is kno…
View article: Author response: Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing
Author response: Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Drosophila circadian pacemaker consist…
View article: 5-HT2A deletion protects against Clozapine-induced hyperglycemia
5-HT2A deletion protects against Clozapine-induced hyperglycemia Open
View article: Identifying the <i>In Vivo</i> Cellular Correlates of Antipsychotic Drugs
Identifying the <i>In Vivo</i> Cellular Correlates of Antipsychotic Drugs Open
GPCRs such as 5-HT2A and D2 are implicated in the therapeutic and the side effects of antipsychotics. However, the pattern of brain activity that leads to the behavioral effects of antipsychotics is poorly understood. To address…
View article: The effects of type I collagenase on the degelification of chimpanzee (Pan troglodytes) semen plug and sperm quality
The effects of type I collagenase on the degelification of chimpanzee (Pan troglodytes) semen plug and sperm quality Open
View article: Genetic studies on egg production traits in IWN and IWP strains of White Leghorn chicken
Genetic studies on egg production traits in IWN and IWP strains of White Leghorn chicken Open
The genetic study was conducted using data generated on 669 and 718 birds of IWN and IWP strains, respectively at the Poultry Complex, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand. The traits mea…