Radim Kučera
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View article: Cyclodextrin mediated non-aqueous electrophoresis for chiral separations of anionic boron clusters
Cyclodextrin mediated non-aqueous electrophoresis for chiral separations of anionic boron clusters Open
Anionic boron cluster compounds have recently made their way into many areas including medicinal chemistry and sensors due to favorable physical-chemical properties and their various biological activity. Notwithstanding the inherent chiral…
View article: Carbon-Substituted Amines of the Cobalt Bis(dicarbollide) Ion: Stereochemistry and Acid–Base Properties
Carbon-Substituted Amines of the Cobalt Bis(dicarbollide) Ion: Stereochemistry and Acid–Base Properties Open
Organic amines are found to be abundant in natural living systems. They also constitute an inestimable family of building blocks available in drug design. Considering the man-made cluster [(1,2-C2B9H11)2-3,3'-Co(III)]- ion (1-) and its app…
View article: Different behavior of food-related benzoic acids toward iron and copper
Different behavior of food-related benzoic acids toward iron and copper Open
Benzoic acids, which are commonly found in food, are also produced by human microbiota from other dietary phenolics. The aim was to investigate the interactions of 8 food-related benzoic acids with the physiological metals iron and copper …
View article: Cannabidiol disrupts tryptophan metabolism in the human term placenta
Cannabidiol disrupts tryptophan metabolism in the human term placenta Open
The increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's influence on try…
View article: Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C Open
Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those involving trypto…
View article: Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries
Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries Open
Within this review, we thoroughly explored supercritical fluid chromatography (SFC) columns used across > 3000 papers published from the first study carried out under SFC conditions in 1962 to the end of 2022. We focused on the open tubula…
View article: What is the role of current mass spectrometry in pharmaceutical analysis?
What is the role of current mass spectrometry in pharmaceutical analysis? Open
The role of mass spectrometry (MS) has become more important in most application domains in recent years. Pharmaceutical analysis is specific due to its stringent regulation procedures, the need for good laboratory/manufacturing practices,…
View article: Antimycobacterial pyridine carboxamides: From design to in vivo activity
Antimycobacterial pyridine carboxamides: From design to in vivo activity Open
Tuberculosis is the number one killer of infectious diseases caused by a single microbe, namely Mycobacterium tuberculosis (Mtb). The success rate of curing this infection is decreasing due to emerging antimicrobial resistance. Therefore, …
View article: 3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes
3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes Open
Flavonoids were screened for chelation of Co 2+ ions. The most active, 3-hydroxyflavone and baicalein, as well as inactive quercetin were further tested (the cobalt-triggered Fenton chemistry and erythrocyte lysis in the presence of cobalt…
View article: Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives Open
The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations. However, the probes suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to impr…
View article: CCDC 2119374: Experimental Crystal Structure Determination
CCDC 2119374: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2119375: Experimental Crystal Structure Determination
CCDC 2119375: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives Open
The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations, however, they suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to improve th…
View article: Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives Open
The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations, however, they suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to improve th…
View article: Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives Open
The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations, however, they suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to improve th…
View article: Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives Open
The short oligodeoxynucleotide (ODN) probes are suitable for good discrimination of point mutations, however, they suffer from low melting temperatures. In this work, the strategy of using acridine-4-carboxamide intercalators to improve th…
View article: Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells
Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells Open
Because cancer is the second leading cause of death globally, investigation of new photosensitizers for photodynamic therapy is highly desirable. In this work, different peripherally substituted subphthalocyanines (SubPcs) with either a be…
View article: Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo
Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo Open
2,3-Dehydrosilybin (DHS) was previously shown to chelate and reduce both copper and iron ions. In this study, similar experiments with 2,3-dehydrosilychristin (DHSCH) showed that this congener of DHS also chelates and reduces both metals. …
View article: Peripherally Crowded Cationic Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy
Peripherally Crowded Cationic Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy Open
Photodynamic therapy is a treatment modality of cancer based on the production of cytotoxic species upon the light activation of photosensitizers. Zinc phthalocyanine photosensitizers bearing four or eight bulky 2,6-di(pyridin-3-yl)phenoxy…
View article: Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit during Gestation
Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit during Gestation Open
Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective propert…
View article: Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation
Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation Open
L-Tryptophan is an essential amino acid and a precursor of several physiologically active metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan metabolism have been identified, giving rise to various m…
View article: Serotonin homeostasis in the materno‐foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO‐A) in uptake and degradation of serotonin by human and rat term placenta
Serotonin homeostasis in the materno‐foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO‐A) in uptake and degradation of serotonin by human and rat term placenta Open
Aim Serotonin is crucial for proper foetal development, and the placenta has been described as a ‘donor’ of serotonin for the embryo/foetus. However, in later stages of gestation the foetus produces its own serotonin from maternally‐derive…
View article: N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers
N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers Open
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds conta…