Radko Avi
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View article: The effect of policy measures, school holidays and travel on the incidence of SARS-CoV-2 infection in children and adults in Estonia from 2021 to 2022
The effect of policy measures, school holidays and travel on the incidence of SARS-CoV-2 infection in children and adults in Estonia from 2021 to 2022 Open
Purpose The policy measures implemented during the COVID-19 pandemic, travel and school holidays could have influenced the spread of SARS-CoV-2 infection in children and adults differently. We aimed to determine the effect of policy measur…
View article: Transmitted HIV-1 drug resistance in Estonian residents and Ukrainian refugees in 2020 and 2022
Transmitted HIV-1 drug resistance in Estonian residents and Ukrainian refugees in 2020 and 2022 Open
Identifying HIV DRMs using HIVdb Program combined with CPR tools gives comprehensive overview of transmitted drug resistance. Resistance testing might be necessary before initiating antiretroviral therapy if the first-line treatment does n…
View article: Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022
Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022 Open
Purpose We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries. Methods SARS-CoV-2 sequences in 2021–2022 from a nationwide study were incl…
View article: SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic
SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic Open
Background The COVID-19 pandemic was characterised by rapid waves of disease, carried by the emergence of new and more infectious SARS-CoV-2 virus variants. How the pandemic unfolded in various locations during its first two years has yet …
View article: No transmitted drug resistance to HIV integrase strand-transfer inhibitors after their scale-up in Estonia in 2017
No transmitted drug resistance to HIV integrase strand-transfer inhibitors after their scale-up in Estonia in 2017 Open
Although no major INSTI mutations were found, close monitoring of INSTI SDRMs is needed considering the extensive use of the first- and second-generation INSTIs. PR-RT TDR is slowly rising in Estonia, indicating the need for continuous sur…
View article: Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study
Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study Open
Background Estonia has a typical Eastern European HIV epidemic where the most frequent co-infection is chronic hepatitis C (HCV). We aimed to describe the changes in HCV prevalence, the distribution of HCV genotypes (GT), and HCV treatment…
View article: Presenting a conceptual framework for an HIV prevention and care continuum and assessing the feasibility of empirical measurement in Estonia: A case study
Presenting a conceptual framework for an HIV prevention and care continuum and assessing the feasibility of empirical measurement in Estonia: A case study Open
Our findings suggest that developing a cohesive model for HIV prevention and treatment is feasible and reflects the bi-directional relationships between prevention and care. The integrated continuum model indicates the major factors which …
View article: Dynamics of hepatitis C epidemic among people living with HIV in Estonia
Dynamics of hepatitis C epidemic among people living with HIV in Estonia Open
Background Estonia has a typical Eastern European HIV epidemic where the most frequent co-infection is chronic hepatitis C (HCV). We aimed to describe the changes in HCV prevalence, the distribution of HCV genotypes (GT), and HCV treatment…
View article: The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx
The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx Open
Comparison of LAg and BRAI results in this mostly CRF06_cpx-infected population showed good concordance for incidence classification. Our finding of a higher recency rate with BRAI in this population is likely related to the longer MDRI fo…
View article: Virome analysis of PRJNA361402 - reads
Virome analysis of PRJNA361402 - reads Open
Raw output files from virome analysis of [PRJNA361402](https://www.ncbi.nlm.nih.gov/sra?term=PRJNA361402) study using [virome-quant workflow](https://github.com/avilab/vs). ## Files samples_norm.tsv -- ids and ftp links of analysed runs (s…
View article: Virome analysis of PRJNA361402 - reads
Virome analysis of PRJNA361402 - reads Open
Raw output files from virome analysis of [PRJNA361402](https://www.ncbi.nlm.nih.gov/sra?term=PRJNA361402) study using [virome-quant workflow](https://github.com/avilab/vs). ## Files samples_norm.tsv -- ids and ftp links of analysed runs (s…
View article: Virome Analysis Of Prjna361402
Virome Analysis Of Prjna361402 Open
Raw output files from virome analysis of [PRJNA361402](https://www.ncbi.nlm.nih.gov/sra?term=PRJNA361402) study using [virome-quant workflow](https://github.com/avilab/vs).
View article: <scp>HIV</scp> incidence in the Estonian population in 2013 determined using the <scp>HIV</scp>‐1 limiting antigen avidity assay
<span>HIV</span> incidence in the Estonian population in 2013 determined using the <span>HIV</span>‐1 limiting antigen avidity assay Open
Objectives Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV…
View article: T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use
T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use Open
Intravenous drug use (IDU) is one of the most important transmission routes for blood borne viruses, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). These infections alter the subset dist…
View article: A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs
A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs Open
Our results suggest that among PWID CCL5 haplotype D and CCR5 HHG*1 independently protects against HCV. Our findings highlight the importance of CCL5 genetic variability and CCL5-CCR5 axis on the susceptibility to HCV.
View article: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis
Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis Open
Most TDR strains in SSA and SSEA arose independently, suggesting that ARV regimens with a high genetic barrier to resistance combined with improved patient adherence may mitigate TDR increases by reducing the generation of new ARV-resistan…