Background: To address the disadvantages associated with traditional antibiotic treatments, we propose a precision microbiome modulation therapy which combines curated faecal microbiota transplantation (FMT) with particular bacteriophage (phage) for Helicobacter pylori eradication. Methods: The phage component was designed to ensure high lytic efficiency and specificity against H. pylori while minimizing resistance development. The FMT formulation has been thoroughly investigated for stability and microbial variet…

Abstract Background: Surgical meshes used in hernia repair face long-term challenges, particularly postoperative complications such as chronic inflammation and poor tissue integration leading to much more complications such as hernia recurrence. Objective: This study proposes a mesh with dual-function bioactive coating which is a mesh that modulated in a way to suppress acute immune response to improve healing outcomes and reduce recurrence rates. Methods: The mesh designed to have two functional layers. The first…