Rafael Alonso
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View article: Advanced Management in Burn Patients
Advanced Management in Burn Patients Open
This review highlights the comprehensive, multidisciplinary approach necessary for the management of burn patients, emphasizing initial stabilization, surgical intervention, critical care, and rehabilitation. Key aspects include prompt air…
View article: Estudio de la permitividad dieléctrica de la nieve húmeda mediante simulación FEM de mezclas aleatorias de materiales dieléctricos
Estudio de la permitividad dieléctrica de la nieve húmeda mediante simulación FEM de mezclas aleatorias de materiales dieléctricos Open
En este trabajo presentamos los primeros pasos en el estudio de la permitividad dieléctrica de la nieve empleando simulaciones FEM. Estudiamos el comportamiento difusivo de estructuras aleatorias bidimensionales que imitan la microestructu…
View article: Diseño e Implementación de un Albedómetro Espectral. Variación del Albedo del Manto Nivoso con Diferentes Contaminantes
Diseño e Implementación de un Albedómetro Espectral. Variación del Albedo del Manto Nivoso con Diferentes Contaminantes Open
Desarrollo de un albedómetro espectral (200-2500 nm) para medir simultáneamente radiación solar incidente y reflejada en la superficie del manto nivoso. Posteriormente se analiza la variación espectral provocada por distintos contaminantes…
View article: Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy
Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy Open
UroA might be a potential therapeutic agent to halt MM disease progression or to overcome resistance when used in combination. Video Abstract.
View article: Abdominal sepsis caused by Enterobacter ludwigii in a 72-year-old patient on chronic hemodialysis, with lack of vascular accesses, complicated by cholecystitis and with non-occlusive thrombosis of the superior vena cava and right atrium
Abdominal sepsis caused by Enterobacter ludwigii in a 72-year-old patient on chronic hemodialysis, with lack of vascular accesses, complicated by cholecystitis and with non-occlusive thrombosis of the superior vena cava and right atrium Open
Infections are very common complications among patients on chronic hemodialysis. Hemodialysis patients with a catheter have a 2- to 3-fold increased risk of hospitalization for infection and death compared with patients with an arterioveno…
View article: Análisis con un radar SFCW de la estructura del manto nivoso: medidas experimentales y simulación
Análisis con un radar SFCW de la estructura del manto nivoso: medidas experimentales y simulación Open
En este trabajo se analizan las propiedades físicas de las capas que conforman el manto nivoso y se comparan las medidas experimentales realizadas con un radar con las simuladas mediante los datos climatológicos del entorno del radar. Las …
View article: A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis
A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis Open
Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple sco…
View article: A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis
A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis Open
Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple sco…
View article: Data from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Data from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Open
Purpose:The gut microbiota plays important roles in health and disease. We questioned whether the gut microbiota and related metabolites are altered in monoclonal gammopathies and evaluated their potential role in multiple myeloma and its …
View article: Supplementary Data 1 from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Supplementary Data 1 from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Open
Supplementary Material
View article: Supplementary Data 1 from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Supplementary Data 1 from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Open
Supplementary Material
View article: Data from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Data from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Open
Purpose:The gut microbiota plays important roles in health and disease. We questioned whether the gut microbiota and related metabolites are altered in monoclonal gammopathies and evaluated their potential role in multiple myeloma and its …
View article: Recovery of uninvolved heavy/light chain pair immunoparesis in newly diagnosed transplant-eligible myeloma patients complements the prognostic value of minimal residual disease detection
Recovery of uninvolved heavy/light chain pair immunoparesis in newly diagnosed transplant-eligible myeloma patients complements the prognostic value of minimal residual disease detection Open
Immunoparesis (IP) in multiple myeloma (MM) patients can be measured by classic assessment of immunoglobulin (Ig) levels or by analysis of the uninvolved heavy/light chain pair of the same immunoglobulin (uHLC) by the Hevylite® assay. In t…
View article: Clinical Outcomes of Patients with Multiple Myeloma after Daratumumab Failure
Clinical Outcomes of Patients with Multiple Myeloma after Daratumumab Failure Open
Anti-CD38 monoclonal antibody (MoAB) therapy has significantly improved the prognosis of patients with multiple myeloma. However, not all patients sustain durable responses. We aimed to describe the natural history of patients relapsed or …
View article: P948: REAL-WORLD EVIDENCE OF BISPHOSPHONATES FOR MULTIPLE MYELOMA
P948: REAL-WORLD EVIDENCE OF BISPHOSPHONATES FOR MULTIPLE MYELOMA Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Bisphosphonates are widely used in multiple myeloma; but only a randomized clinical have showed that zolendronic acid improved survival as well as reduce the numbe…
View article: Correction: Large-scale real-life analysis of survival and usage of therapies in multiple myeloma
Correction: Large-scale real-life analysis of survival and usage of therapies in multiple myeloma Open
View article: Large-scale real-life analysis of survival and usage of therapies in multiple myeloma
Large-scale real-life analysis of survival and usage of therapies in multiple myeloma Open
View article: Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma: Results of the Compassionate Use or the Expanded Access Program in Spain
Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma: Results of the Compassionate Use or the Expanded Access Program in Spain Open
Belantamab-mafodotin (belamaf) is a novel antibody-drug conjugate targeting B-cell maturation antigen that showed anti-myeloma activity in patients with relapsed and refractory multiple myeloma (RRMM). We performed an observational, retros…
View article: Radiomics analysis of bone marrow biopsy locations in [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma
Radiomics analysis of bone marrow biopsy locations in [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma Open
View article: NTS, NTSR1 and ERs in the Pituitary–Gonadal Axis of Cycling and Postnatal Female Rats after BPA Treatment
NTS, NTSR1 and ERs in the Pituitary–Gonadal Axis of Cycling and Postnatal Female Rats after BPA Treatment Open
The neuropeptide neurotensin (NTS) is involved in regulating the reproductive axis and is expressed at each level of this axis (hypothalamus–pituitary–gonads). This dependence on estrogen levels has been widely demonstrated in the hypothal…
View article: Cell Count Differentials by Cytomorphology and Next-Generation Flow Cytometry in Bone Marrow Aspirate: An Evidence-Based Approach
Cell Count Differentials by Cytomorphology and Next-Generation Flow Cytometry in Bone Marrow Aspirate: An Evidence-Based Approach Open
Despite a lack of evidence, a bone marrow aspirate differential of 500 cells is commonly used in the clinical setting. We aimed to test the performance of 200-cell counts for daily hematological workup. In total, 660 consecutive samples we…
View article: Global real-life analysis of survival and usage of therapies in multiple myeloma
Global real-life analysis of survival and usage of therapies in multiple myeloma Open
Background: Survival in multiple myeloma has improved significantly in recent years, especially in young patients. This is due to the introduction of new drugs with new mechanisms of action . We reviewed the evolution of the survival of pa…
View article: Real-World Outcomes of Belantamab Mafodotin for Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results of a Spanish Expanded Access Program (EAP)
Real-World Outcomes of Belantamab Mafodotin for Relapsed/Refractory Multiple Myeloma (RRMM): Preliminary Results of a Spanish Expanded Access Program (EAP) Open
View article: Bone marrow segmentation and radiomics analysis of [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma
Bone marrow segmentation and radiomics analysis of [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma Open
A proof-of-concept for the extraction and evaluation of bone marrow radiomics features of [18F]FDG PET images was proposed and implemented. The validation showed the possible use of these features for the image-based assessment …
View article: Outcomes and patterns of treatment in chronic myeloid leukemia, a global perspective based on a real-world data global network
Outcomes and patterns of treatment in chronic myeloid leukemia, a global perspective based on a real-world data global network Open
View article: Tumor Reduction in Multiple Myeloma: New Concepts for New Therapeutics
Tumor Reduction in Multiple Myeloma: New Concepts for New Therapeutics Open
The development of new resources for a more accurate diagnosis and response assessment in multiple myeloma has been a long process for decades, mainly since the middle of the 20th century. During this time, the succession of technical adva…
View article: Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma
Efficacy of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies Including Myeloma Open
Multiple myeloma (MM) remains an incurable plasma cell malignancy. While its origin is enigmatic, an association with infectious pathogens including hepatitis C virus (HCV) has been suggested. Here we report nine patients with monoclonal g…
View article: The changing landscape of relapsed and/or refractory multiple myeloma (MM): fundamentals and controversies
The changing landscape of relapsed and/or refractory multiple myeloma (MM): fundamentals and controversies Open
View article: The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach
The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach Open
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and eval…
View article: Making clinical decisions based on measurable residual disease improves the outcome in multiple myeloma
Making clinical decisions based on measurable residual disease improves the outcome in multiple myeloma Open
The assessment of measurable residual disease (MRD) in bone marrow has proven of prognostic relevance in patients with multiple myeloma (MM). Nevertheless, and unlike other hematologic malignancies, the use of MRD results to make clinical …