Raul C. Ribeiro
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View article: Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease Relapse
Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease Relapse Open
Relapse remains the leading cause of mortality in pediatric acute myeloid leukemia (AML), yet the genetic changes contributing to relapse remain incompletely defined. To address this gap, we performed whole-genome sequencing and targeted-c…
View article: Clinical experience of using integrated whole genome and transcriptome sequencing as a framework for pediatric and adolescent acute myeloid leukemia diagnosis and risk assessment
Clinical experience of using integrated whole genome and transcriptome sequencing as a framework for pediatric and adolescent acute myeloid leukemia diagnosis and risk assessment Open
Pediatric acute myeloid leukemia (AML) exhibits distinct genetic characteristics, including unique driver alterations and mutations with prognostic and therapeutic implications. Cytogenetics study, along with Next Generation Sequencing (NG…
View article: Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia
Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia Open
View article: The People-First Liver Charter
The People-First Liver Charter Open
View article: Venetoclax combined with escalating doses of homoharringtonine, low-dose cytarabine, and granulocyte colony-stimulating factor demonstrates feasibility and tolerability for remission induction in pediatric acute myeloid leukemia
Venetoclax combined with escalating doses of homoharringtonine, low-dose cytarabine, and granulocyte colony-stimulating factor demonstrates feasibility and tolerability for remission induction in pediatric acute myeloid leukemia Open
View article: Integrated Whole Genome and Transcriptome Sequencing as a Framework for Pediatric and Adolescent AML Diagnosis and Risk Assessment
Integrated Whole Genome and Transcriptome Sequencing as a Framework for Pediatric and Adolescent AML Diagnosis and Risk Assessment Open
View article: Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML
Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML Open
Cytarabine, daunorubicin, and etoposide (ADE) have been the standard backbone of induction chemotherapy regimen for patients with pediatric acute myeloid leukemia (pAML) for >5 decades. However, chemoresistance is still a major concern,…
View article: Long-read epigenomic diagnosis and prognosis of Acute Myeloid Leukemia
Long-read epigenomic diagnosis and prognosis of Acute Myeloid Leukemia Open
View article: REVISÃO INTEGRATIVA SOBRE A INCIDÊNCIA DE PARTO VAGINAL E CESARIANAS NO BRASIL NOS ÚLTIMOS DEZ ANOS
REVISÃO INTEGRATIVA SOBRE A INCIDÊNCIA DE PARTO VAGINAL E CESARIANAS NO BRASIL NOS ÚLTIMOS DEZ ANOS Open
Este estudo revisou a incidência de partos vaginais e cesarianas no Brasil nos últimos dez anos, com o objetivo de analisar as tendências dessas modalidades de parto e os fatores associados à escolha. A pesquisa revelou que, apesar de algu…
View article: Early death and intracranial hemorrhage prediction in acute promyelocytic leukemia: validation of a risk score in a chemotherapy plus ATRA cohort from an international consortium
Early death and intracranial hemorrhage prediction in acute promyelocytic leukemia: validation of a risk score in a chemotherapy plus ATRA cohort from an international consortium Open
Not available.
View article: Data from Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia
Data from Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia Open
Purpose:Cytarabine (also known as ara-C) has been the backbone of acute myeloid leukemia (AML) chemotherapy for more than five decades. Recent pharmacogenomics-based 10-SNP ara-C (ACS10) scores showed low ACS10 (≤0) to be associated with p…
View article: 12485 Evaluating B7-H3-CAR T Cell Therapy In Preclinical Models Of Pediatric Adrenocortical Tumors
12485 Evaluating B7-H3-CAR T Cell Therapy In Preclinical Models Of Pediatric Adrenocortical Tumors Open
Disclosure: E.M. Pinto: None. R. Epperly: None. T. Santiago: None. H. Sheppard: None. M. Clay: None. C. Morton: None. P. Nguyen: None. Y. Zhou: None. M.A. Woolard: None. C. O'Reilly: None. J. Justice: None. W. Akers: None. M. Johnson: None…
View article: Supplementary Data 1 from Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia
Supplementary Data 1 from Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia Open
Supplementary Tables and Figures
View article: Pediatric Adrenocortical Carcinoma: The Nuts and Bolts of Diagnosis and Treatment and Avenues for Future Discovery
Pediatric Adrenocortical Carcinoma: The Nuts and Bolts of Diagnosis and Treatment and Avenues for Future Discovery Open
Adrenocortical tumors (ACTs) are infrequent neoplasms in children and adolescents and are typically associated with clinical symptoms reflective of androgen overproduction. Pediatric ACTs typically occur in the context of a germline TP5…
View article: Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials
Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials Open
View article: Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala
Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala Open
PURPOSE This study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala. METHODS The Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is t…
View article: Effect of American genomic ancestry on severe toxicities in children with acute lymphoblastic leukemia in the Amazon region
Effect of American genomic ancestry on severe toxicities in children with acute lymphoblastic leukemia in the Amazon region Open
Background Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system characterized by a clonal expansion of abnormal lymphocyte precursor cells. ALL is the most common form of cancer in children, but despite advances in …
View article: Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia
Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia Open
Importance Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts. Objective To assess whether varying inte…
View article: International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors: indications, therapy, and management of adverse effects
International consensus on mitotane treatment in pediatric patients with adrenal cortical tumors: indications, therapy, and management of adverse effects Open
Objective Mitotane is an important cornerstone in the treatment of pediatric adrenal cortical tumors (pACC), but experience with the drug in the pediatric age group is still limited and current practice is not guided by robust evidence. Th…
View article: Isosexual precocious pseudopuberty during mitotane treatment in a child with adrenocortical carcinoma: A case report
Isosexual precocious pseudopuberty during mitotane treatment in a child with adrenocortical carcinoma: A case report Open
Background: Mitotane is employed as adjuvant therapy in managing adrenocortical carcinoma in pediatric patients. While various adverse effects, such as estrogen-like manifestations, are well-documented in adults, there is limited knowledge…
View article: Ommaya reservoir use in pediatric ALL and NHL: a review at St. Jude Children’s Research Hospital
Ommaya reservoir use in pediatric ALL and NHL: a review at St. Jude Children’s Research Hospital Open
View article: COVID-19 in Pediatric Patients With Acute Lymphoblastic Leukemia or Lymphoma
COVID-19 in Pediatric Patients With Acute Lymphoblastic Leukemia or Lymphoma Open
Importance COVID-19 in pediatric patients with acute lymphoblastic leukemia or lymphoma (ALL/LLy) has not been described in detail and may affect chemotherapy administration and long-term outcomes. Objective To describe the clinical presen…
View article: Multiple TP53 p.R337H haplotypes and implications for tumor susceptibility
Multiple TP53 p.R337H haplotypes and implications for tumor susceptibility Open
View article: SAT274 Multilocus Imprinting Disorder Due To Genome-wide Paternal Uniparental Disomy Associated With Adrenocortical Tumors
SAT274 Multilocus Imprinting Disorder Due To Genome-wide Paternal Uniparental Disomy Associated With Adrenocortical Tumors Open
Disclosure: E.M. Pinto: None. E. Lalli: None. G. Wu: None. R. Ribeiro: None. G. Zambetti: None. Pediatric adrenocortical tumor (ACT) is an uncommon malignancy frequently associated with Li-Fraumeni syndrome, a familial cancer predispositio…
View article: Benefit of continuous kidney replacement therapy for managing tumor lysis syndrome in children with hematologic malignancies
Benefit of continuous kidney replacement therapy for managing tumor lysis syndrome in children with hematologic malignancies Open
Introduction Tumor lysis syndrome (TLS) is often diagnosed in children with hematological malignancies and can be life threatening due to metabolic disturbances. Continuous renal replacement therapy (CKRT) can reverse these disturbances re…
View article: Rituximab administration in pediatric patients with newly diagnosed acute lymphoblastic leukemia
Rituximab administration in pediatric patients with newly diagnosed acute lymphoblastic leukemia Open
View article: Childhood Leukemia Survival in the US-Mexico Border: Building Sustainable Leukemia Care Using Health Systems Strengthening Models
Childhood Leukemia Survival in the US-Mexico Border: Building Sustainable Leukemia Care Using Health Systems Strengthening Models Open
PURPOSE Pediatric leukemia outcomes are poor in most low- and middle-income countries (LMICs) and exacerbated by health care systems ill equipped to manage cancer. Effective leukemia management in LMICs involves curating epidemiologic data…
View article: Clinical impact of minimal residual disease in blood and bone marrow of children with acute myeloid leukemia
Clinical impact of minimal residual disease in blood and bone marrow of children with acute myeloid leukemia Open
The prognostic significance of bone marrow minimal residual disease (MRD) in pediatric patients with acute myeloid leukemia (AML) is well characterized, but the impact of blood MRD is not known. We, therefore, used flow cytometric assessme…
View article: Table S6 from Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease–Directed Therapy
Table S6 from Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease–Directed Therapy Open
Supplementary Table S6
View article: Supplementary Data-1 from Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease–Directed Therapy
Supplementary Data-1 from Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease–Directed Therapy Open
Supplementary Data Legend, Supplementary Table (S7) and Supplementary Figures (S1-S6)