Explanipedia

Antibacterial and Potentiating Activity of the Essential Oil of Citrus bergamia Risso (Rutaceae) Open

Fábio Caboclo Moreira, José Thyálisson da Costa Silva, Damiana Gonçalves de Sousa Freitas, Ademar Maia Filho, Gabriel de Oliveira Lôbo , et al. · 2025

Antimicrobial resistance represents a growing threat to global public health, exacerbated by the improper use of antibiotics. This situation drives the search for alternative therapies, such as essential oils from medicinal plants of the R…

Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry Open

Alessio Cortellini, Valentina Santo, Leonardo Brunetti, Edoardo Garbo, David J. Pinato , et al. · 2025

Background With nearly one-third of patients with advanced non-small cell lung cancer (NSCLC) and PD-L1 Tumor Proportion Score≥50% surviving beyond 5 years following first-line pembrolizumab, long-term outcomes challenge traditional paradi…

The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations Open

K M Higgins, Olga P. Nyssen, Joshua Southern, Ivan Laponogov, Ana Miralles-Marco , et al. · 2025

A IMPORTÂNCIA DAS PRÁTICAS CULTURAIS TRADICIONAIS NO ENSINO DA LÍNGUA INGLESA NA MODALIDADE EJA DA EMEF SÃO JOÃO BATISTA, CAMETÁ-PA Open

Rita Barros, Andréa Silva Domingues, Luiz Antônio Pereira Lima Neto, Lucas Rodrigues Lopes, R. Ferreira · 2025

All spoken language is full of cultural elements historically constructed, which directly influence the way of acting and relating to the people who use it. This research aimed to understand the importance of traditional cultural practices…

HIPERTENSÃO MALIGNA COM MÚLTIPLAS LESÕES DE ÓRGÃO ALVO: UM RELATO DE CASO Open

Matheus Catão Tsugami, Lorayne Ugolini Santana, Ygor Costa Barros, Thatiane Gabriela Guimarães Pereira, Mattheus Marques Rodrigues de Souza , et al. · 2025

O artigo tem como finalidade relatar o caso de um paciente que apresentou aumento súbito da pressão arterial, associado a alteração renal com evolução para insuficiência renal rapidamente progressiva com necessidade de hemodiálise, evoluçã…

Immune profiling of gastric adenocarcinomas in EU and LATAM countries identifies global differences in immune subgroups and microbiome influence Open

Tessa S. Groen-van Schooten, Manuel Cabeza-Segura, Rui M. Ferreira, Carolina Martínez‐Ciarpaglini, Rita Barros , et al. · 2025

Background Gastric cancer (GC) patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in previous large-scale multi-omic studies that have identified clinically relevant subgroups. The LEGACY study…

Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project Open

Rodrigo Dienstmann, Erika Ruiz‐García, María Alsina, Fiorella Ruíz‐Pace, Tessa S. Groen-van Schooten , et al. · 2025

Implementation of an Educational Intervention for Gastric Cancer Awareness in the General Population in CELAC and Europe: A Strategy Proposed by the LEGACy Consortium Open

Juan Antonio Carbonell‐Asins, Elena Jiménez-Martí, Sergio Romero, Eduardo García, Ana Miralles-Marco , et al. · 2025

Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry Open

Alessio Cortellini, Leonardo Brunetti, Giuseppina Rita Di Fazio, Edoardo Garbo, David J. Pinato , et al. · 2025

Background Pembrolizumab monotherapy is an established front-line treatment for advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) tumor proportion score (TPS)≥50%. However, real-world data on its long-…

Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression Open

Carolina Martínez‐Ciarpaglini, Rita Barros, Carmelo Caballero, Hugo Boggino, Lorena Alarcón-Molero , et al. · 2025

Gastric cancer hospital-based registry: real-world gastric cancer data from Latin America and Europe Open

Berenice Freile, Tessa S. Groen-van Schooten, Sarah Derks, Fátima Carneiro, Céu Figueiredo , et al. · 2024

Background: Gastric cancer has a high incidence and mortality rate worldwide. Epidemiological, clinical, and molecular features significantly impact patient outcomes. In regions lacking a national gastric cancer registry, hospital-based re…

Quadruple therapies show a higher eradication rate compared to standard triple therapy for <i>Helicobacter pylori</i> infection within the LEGACy consortium. A multicenter observational study in European and Latin American countries Open

Patricio Medel‐Jara, Diego Reyes-Placencia, Eduardo Fuentes‐López, Óscar Corsi, Gonzalo Latorre , et al. · 2024

Introduction Gastric cancer (GC) is one of the most lethal malignancies worldwide. Helicobacter pylori is the primary cause of GC; therefore, its eradication reduces the risk of developing this neoplasia. There is extensive evidence regard…

Monensin as potential drug for treatment of SLeX-positive tumors Open

Ana Filipa Costa, Emanuel Senra, Diana Campos, Isabel Faria‐Ramos, Liliana Santos-Ferreira , et al. · 2024

Colorectal (CRC) and gastric (GC) cancers remain the top lethal cancers and targeted therapies in this setting are still very limited. Sialyl Lewis X (SLeX), a cancer-associated glycan highly expressed in both CRC and GC, plays a crucial r…

Implementation of an Educational Intervention for Gastric Cancer Awareness in the General Population in Celac and Europe. A Strategy Proposed by the Legacy Consortium Open

Tania Fleitas, Juan Antonio Carbonell‐Asins, Elena Jiménez-Martí, Sergio Romero, Eduardo García‐Galea , et al. · 2024

Implementation of an Educational Intervention for Gastric Cancer Awareness in the General Population in CELAC and Europe. A Strategy Proposed by the LEGACy Consortium Open

Juan Antonio Carbonell‐Asins, Elena Jiménez-Martí, Sergio Romero, Eduardo García‐Galea, Beatriz López , et al. · 2024

1552P Clinical multi-omics analysis of gastric cancer (GC) in Europe (EU) and Latin America (LatAm): The LEGACy project Open

T.C. Fleitas, Fiorella Ruíz‐Pace, T. van Schooten, Rita Barros, E. Fernandez-Figueroa , et al. · 2023

Histopathology of Psoriatic Arthritis Synovium—A Narrative Review Open

Catarina Tenazinha, Rita Barros, João Eurico Fonseca, Elsa Vieira‐Sousa · 2022

Psoriatic arthritis (PsA) is a phenotypically heterogeneous chronic inflammatory disease associated to type I major histocompatibility complex alleles whose complex pathogenesis is still not completely understood. The psoriatic synovium sh…

Gloeothece sp.—Exploiting a New Source of Antioxidant, Anti-Inflammatory, and Antitumor Agents Open

Helena M. Amaro, Rita Barros, Tânia G. Tavares, Raquel Almeida, Isabel Sousa‐Pinto , et al. · 2021

Bioactive lipidic compounds of microalgae, such as polyunsaturated fatty acids (PUFA) and carotenoids, can avoid or treat oxidation-associated conditions and diseases like inflammation or cancer. This study aimed to assess the bioactive po…

Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients Open

Sara Ribeirinho-Soares, Diana Pádua, Ana Luísa Amaral, Elvia Valentini, Daniela Azevedo , et al. · 2021

Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus Open

Hugo Osório, Cátia Silva, Marta Ferreira, Irene Gullo, Valdemar Máximo , et al. · 2021

Proteomics is a powerful approach to study the molecular mechanisms of cancer. In this study, we aim to characterize the proteomic profile of gastric cancer (GC) in patients with diabetes mellitus (DM) type 2. Forty GC tissue samples inclu…

Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors Open

Carlos Clavel, Laura Grisanti, Roland Zemla, Amélie Rezza, Rita Barros , et al. · 2020

How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18Cre to target embryonic DP precursors, we ablate the transcription factor Sox2 early and efficiently, resulting in di…

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin Open

Diana Pádua, Rita Barros, Ana Luísa Amaral, Patrícia Mesquita, Ana Filipa Araújo Freire , et al. · 2020

Gastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription f…

S100P is a molecular determinant of E-cadherin function in gastric cancer Open

Patrı́cia Carneiro, Ana Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira , et al. · 2019

Expression and Clinical Relevance of SOX9 in Gastric Cancer Open

Patrícia Mesquita, Cristina Freire, Nair Lopes, Rosa Gomes, Daniela Azevedo , et al. · 2019

Gastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide. The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment and follow-up…

Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019 Open

Pedro Pimentel‐Nunes, Diogo Libânio, Ricardo Marcos‐Pinto, Miguel Areia, Mārcis Leja , et al. · 2019

Main Recommendations Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and risk stratification for these patients. High definition en…

Prognostic, predictive, and pharmacogenomic assessments of <span>CDX</span>2 refine stratification of colorectal cancer Open

Jarle Bruun, Anita Sveen, Rita Barros, Peter W. Eide, Ina A. Eilertsen , et al. · 2018

We aimed to refine the value of CDX 2 as an independent prognostic and predictive biomarker in colorectal cancer ( CRC ) according to disease stage and chemotherapy sensitivity in preclinical models. CDX 2 expression was evaluated in 1045 …

PO-501 Loss of SOX9 expression is a predictive marker of relapse in gastric cancer Open

Patrícia Mesquita, Cristina Freire, Nair Lopes, Bruno Cavadas, Bruno Pereira , et al. · 2018

Introduction Gastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide. The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment…

Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway? Open

Inês Rolim, Rita Vale Rodrigues, António Bettencourt, Rita Barros, Vânia Camilo , et al. · 2016

We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies…

Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa Open

Rita Barros, Daniela Pereira, Catarina Callé, Vânia Camilo, Ana Isabel Cunha , et al. · 2016

Barrett’s esophagus (BE) is the replacement of the normal esophageal squamous epithelium by a columnar lining epithelium. It is a premalignant condition for the development of adenocarcinoma of the esophagus and esophagogastric junction. B…

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis Open

Joana Oliveira, Cláudia Ribeiro, Rita Barros, Catarina Gomes, Augusto de Matos , et al. · 2015

The tumor microenvironment encompasses several stressful conditions for cancer cells such as hypoxia, oxidative stress and pH alterations. Galectin-3, a well-studied member of the beta-galactoside-binding animal family of lectins has been …

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