Rafael Leite Dantas
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View article: The role of the risk gene CACNA1C in neuroinflammation and peripheral immunity in autism spectrum disorder
The role of the risk gene CACNA1C in neuroinflammation and peripheral immunity in autism spectrum disorder Open
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, restricted and repetitive behaviors and interests, with the severity of symptoms varying greatly…
View article: Small Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile
Small Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile Open
Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous r…
View article: Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa
Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa Open
Anorexia nervosa (AN) is a severe eating disorder characterized by excessive weight loss and lack of recognition of the seriousness of the current low body weight. Individuals with AN frequently exhibit an enhanced inflammatory state and a…
View article: Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders?
Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? Open
Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum…
View article: Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <scp>S100A8</scp>/<scp>A9</scp> alarmins, and <scp>MHC</scp> H‐2 haplotype
Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <span>S100A8</span>/<span>A9</span> alarmins, and <span>MHC</span> H‐2 haplotype Open
Recently, we established a doxycycline‐inducible human tumor necrosis factor alpha (TNFα)‐transgenic mouse line, ihTNFtg. Non‐induced young and elderly mice showed low but constitutive expression of hTNFα due to promoter leakiness. The per…
View article: Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity
Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity Open
Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role in the sensitization phase of CHS by initiating T cell responses to topically applied haptens. The …