Rafael R. C. Cuadrat
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View article: Mapping of the gene network that regulates glycan clock of ageing
Mapping of the gene network that regulates glycan clock of ageing Open
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…
View article: Association of the human gut microbiota with vascular stiffness
Association of the human gut microbiota with vascular stiffness Open
View article: Mapping of the gene network that regulates glycan clock of ageing
Mapping of the gene network that regulates glycan clock of ageing Open
Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…
View article: Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation
Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation Open
Acute coronary syndrome (ACS) remains a major cause of worldwide mortality. The syndrome occurs when blood flow to the heart muscle is decreased or blocked, causing muscle tissues to die or malfunction. There are three main types of ACS: N…
View article: Stool and Ruminal Microbiome Components Associated With Methane Emission and Feed Efficiency in Nelore Beef Cattle
Stool and Ruminal Microbiome Components Associated With Methane Emission and Feed Efficiency in Nelore Beef Cattle Open
Background: The impact of extreme changes in weather patterns on the economy and human welfare is one of the biggest challenges our civilization faces. From anthropogenic contributions to climate change, reducing the impact of farming acti…
View article: Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation
Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation Open
Background: In blood and tissues, dietary and endogenously generated fatty acids (FAs) occur in free form or as part of complex lipid molecules that collectively represent the lipidome of the respective tissue. We assessed associations of …
View article: Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology
Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology Open
Metabolic alterations precede cardiometabolic disease onset. Here we present ceramide- and dihydroceramide-profiling data from a nested case-cohort (type 2 diabetes [T2D, n = 775]; cardiovascular disease [CVD, n = 551]; random subcohort [ …
View article: The role of respiratory microbiota in the protection against viral diseases: respiratory commensal bacteria as next-generation probiotics for COVID-19
The role of respiratory microbiota in the protection against viral diseases: respiratory commensal bacteria as next-generation probiotics for COVID-19 Open
On March 11, 2020, the World Health Organization declared a pandemic of coronavirus infectious disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and imposed the biggest public health challenge f…
View article: SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution
SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution Open
The use of RNA sequencing from wastewater samples is a valuable way for estimating infection dynamics and circulating lineages of SARS-CoV-2. This approach is independent from testing individuals and can therefore become the key tool to mo…
View article: Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol Open
Objective: Low-density lipoprotein cholesterol (LDLc) lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased body …
View article: Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol Open
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METH…
View article: Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol Open
Objective: Low-density lipoprotein cholesterol (LDLc) lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased body …
View article: Stool and ruminal microbiome components associated with methane emission and feed efficiency in Nelore beef cattle.
Stool and ruminal microbiome components associated with methane emission and feed efficiency in Nelore beef cattle. Open
Background: The impact of extreme changes in weather patterns in the economy and human welfare are some of the biggest challenges that our civilization is facing. From the anthropogenic activities that contribute to climate change, reducin…
View article: Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation
Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation Open
Acute coronary syndromes (ACS) remain a major cause of worldwide mortality. ACS diagnosis is done by a combination of factors, such as electrocardiogram and plasma biomarkers. These biomarkers, however, lack the power to accurately stratif…
View article: Putative mobilized colistin resistance genes in the human gut microbiome
Putative mobilized colistin resistance genes in the human gut microbiome Open
Background The high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin, caused by mobilized colistin resistance ( mcr ) genes, poses an unprecedented threat to human health. Understanding the s…
View article: Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study
Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study Open
Background Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships between advanced glycat…
View article: Flavonoid-modifying capabilities of the gut microbiome – an in silico study
Flavonoid-modifying capabilities of the gut microbiome – an in silico study Open
Flavonoids are a major group of dietary plant polyphenols and have a positive health impact, but their modification and degradation in the human gut is still widely unknown. Due to the rise of human gut metagenome data and the assembly of …
View article: Nasopharyngeal Microbial Communities of Patients Infected With SARS-CoV-2 That Developed COVID-19
Nasopharyngeal Microbial Communities of Patients Infected With SARS-CoV-2 That Developed COVID-19 Open
Background SARS-CoV-2 is an RNA virus causing COVID-19. The clinical characteristics and epidemiology of COVID-19 have been extensively investigated, however, only one study so far focused on the patient’s nasopharynx microbiota. In this s…
View article: Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome
Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome Open
The dataset from the article Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome
View article: Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome
Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome Open
The dataset from the article Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome
View article: Nasopharyngeal microbial communities of patients infected with SARS-COV-2 that developed COVID-19
Nasopharyngeal microbial communities of patients infected with SARS-COV-2 that developed COVID-19 Open
Background SARS-CoV-2 is an RNA virus causing COVID-19. The clinical characteristics and epidemiology of COVID-19 have been extensively investigated, however studies focused on the patient’s microbiota are still lacking. In this study, we …
View article: Fecal and Ruminal Microbiome Components Associated With Methane Emission in Beef Cattle.
Fecal and Ruminal Microbiome Components Associated With Methane Emission in Beef Cattle. Open
Background: The impact of extreme changes in weather patterns in the economy and humanity welfare are some of the biggest challenges that our civilization is facing. From the anthropogenic activities that contribute to climate change, redu…
View article: Fecal and Ruminal Microbiome Components Associated With Methane Emission in Beef Cattle.
Fecal and Ruminal Microbiome Components Associated With Methane Emission in Beef Cattle. Open
Background: The impact of extreme changes in weather patterns in the economy and humanity welfare are some of the biggest challenges that our civilization is facing. From the anthropogenic activities that contribute to climate change, redu…
View article: Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples
Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples Open
Background The rise of antibiotic resistance (AR) in clinical settings is of great concern. Therefore, the understanding of AR mechanisms, evolution, and global distribution is a priority for patient survival. Despite all efforts in the el…
View article: ResistomeDB
ResistomeDB Open
The rise of antibiotic resistance (AR) in clinical settings is one of the biggest modern global public health concerns, therefore, the understanding of its mechanisms, evolution and global distribution is a priority due to its impa…
View article: ResistomeDB
ResistomeDB Open
The rise of antibiotic resistance (AR) in clinical settings is one of the biggest modern global public health concerns, therefore, the understanding of its mechanisms, evolution and global distribution is a priority due to its imp…
View article: Global ocean resistome revealed: exploring Antibiotic Resistance Genes (ARGs) abundance and distribution on TARA oceans samples through machine learning tools
Global ocean resistome revealed: exploring Antibiotic Resistance Genes (ARGs) abundance and distribution on TARA oceans samples through machine learning tools Open
The rise of antibiotic resistance (AR) in clinical settings is one of the biggest modern global public health concerns. Therefore, the understanding of AR mechanisms, evolution and global distribution is a priority due to its impact on the…
View article: ResistomeDB
ResistomeDB Open
The rise of antibiotic resistance (AR) in clinical settings is one of the biggest modern global public health concerns, therefore, the understanding of its mechanisms, evolution and global distribution is a priority due to its impa…
View article: Recovering genomic clusters of secondary metabolites from lakes: a Metagenomics 2.0 approach
Recovering genomic clusters of secondary metabolites from lakes: a Metagenomics 2.0 approach Open
Background Metagenomic approaches became increasingly popular in the past decades due to decreasing costs of DNA sequencing and bioinformatics development. So far, however, the recovery of long genes coding for secondary metabolism still r…
View article: Picoplankton Bloom in Global South? A High Fraction of Aerobic Anoxygenic Phototrophic Bacteria in Metagenomes from a Coastal Bay (Arraial do Cabo—Brazil)
Picoplankton Bloom in Global South? A High Fraction of Aerobic Anoxygenic Phototrophic Bacteria in Metagenomes from a Coastal Bay (Arraial do Cabo—Brazil) Open
Marine habitats harbor a great diversity of microorganism from the three domains of life, only a small fraction of which can be cultivated. Metagenomic approaches are increasingly popular for addressing microbial diversity without culture,…