Rafael Gómez
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View article: Reusable and green approach to extract proteins with magnetic nanoparticles coated with carbosilane dendrimers: application to the recovery of whey proteins
Reusable and green approach to extract proteins with magnetic nanoparticles coated with carbosilane dendrimers: application to the recovery of whey proteins Open
The valorisation of industrial waste, such as whey from the dairy industry, offers a sustainable approach to reduce environmental impact while obtaining high value-added products. However, current protein extraction methods are often costl…
View article: Crossing Barriers: PEGylated Gold Nanoparticles as Promising Delivery Vehicles for siRNA Delivery in Alzheimer’s Disease
Crossing Barriers: PEGylated Gold Nanoparticles as Promising Delivery Vehicles for siRNA Delivery in Alzheimer’s Disease Open
Background: The proportion of people suffering from neurodegenerative conditions, such as Alzheimer’s disease (AD), is increasing in the population year on year. Despite the constant effort of researchers, these conditions remain incurable…
View article: Ruthenium(II) complexes containing PEGylated N-heterocyclic carbene ligands for tunning biocompatibility in the fight against cancer
Ruthenium(II) complexes containing PEGylated N-heterocyclic carbene ligands for tunning biocompatibility in the fight against cancer Open
A synthetic procedure was designed for the preparation and characterization of Ag and Ru complexes containing NHC ligands functionalized with PEG fragments. Stability studies were conducted to gain insight of the species in water and other…
View article: Beyond safety: A design examination of facial PPE in paediatric wards
Beyond safety: A design examination of facial PPE in paediatric wards Open
In paediatric wards, establishing therapeutic rapport with children requires employing friendly gestures or an understanding gaze, an aspect inhibited when clinicians wear facial personal protective equipment (PPE). In this case study we e…
View article: Carbosilane Dendritic Amphiphiles from Cholesterol or Vitamin E for Micelle Formation
Carbosilane Dendritic Amphiphiles from Cholesterol or Vitamin E for Micelle Formation Open
Cationic dendritic amphiphiles were prepared through the linkage of interesting hydrophobic molecules such as cholesterol or vitamin E to the focal point of carbosilane dendrons. These new dendritic systems self-assembled in saline, produc…
View article: A proposed modification to the Kellgren and Lawrence classification for knee osteoarthritis using a compartment‐specific approach
A proposed modification to the Kellgren and Lawrence classification for knee osteoarthritis using a compartment‐specific approach Open
Purpose Since Kellgren and Lawrence (KL) originally classified knee osteoarthritis, several authors have reported varying levels of reliability and a lack of uniformity in the use of this classification system. We propose several modificat…
View article: Removing lead from water with carboxylate dendrimers and magnetic nanoparticles modified with carboxylate dendrimers
Removing lead from water with carboxylate dendrimers and magnetic nanoparticles modified with carboxylate dendrimers Open
Contamination of water with heavy metals as lead (Pb 2+ ) is a relevant problematic issue. In this work, we have tested different types of dendritic materials for lead removal from water and further recovery. The systems employed are magne…
View article: Nutritional Composition, Phytochemical Performance, Total Content of Polyphenols, Antioxidant Capacity, Bioactive Compounds of Guavijú Fruits (Eugenia Pungens), and Their Potential Health Benefits
Nutritional Composition, Phytochemical Performance, Total Content of Polyphenols, Antioxidant Capacity, Bioactive Compounds of Guavijú Fruits (Eugenia Pungens), and Their Potential Health Benefits Open
Background: Autochthonous fruits such as Guavijú have beneficial health properties through their bioactive compounds and antioxidant capacity. This study aims to evaluate nutritional composition, phytochemical performance, total content of…
View article: Pegylated Gold Nanoparticles Conjugated with siRNA: Complexes Formation and Cytotoxicity
Pegylated Gold Nanoparticles Conjugated with siRNA: Complexes Formation and Cytotoxicity Open
Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles could be used to advance modern medicine. One significant pharmacological problem is crossing biological barriers by commonly used drugs, e.g., in t…
View article: The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants
The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants Open
The threat of antimicrobial-resistant bacteria is ever increasing and over the past-decades development of novel therapeutic counter measurements have virtually come to a halt. This circumstance calls for interdisciplinary approaches to de…
View article: Immobilization of Alcalase on Silica Supports Modified with Carbosilane and PAMAM Dendrimers
Immobilization of Alcalase on Silica Supports Modified with Carbosilane and PAMAM Dendrimers Open
Enzyme immobilization is a powerful strategy for enzyme stabilization and recyclability. Materials covered with multipoint molecules are very attractive for this goal, since the number of active moieties to attach the enzyme increases with…
View article: Alteration of the HIF-1α/VEGF Signaling Pathway and Disruption of the Cell Cycle by Second Generation Carbosilan Dendrimers
Alteration of the HIF-1α/VEGF Signaling Pathway and Disruption of the Cell Cycle by Second Generation Carbosilan Dendrimers Open
Current therapies against prostate cancer (PCa) disease, such as surgery, radiotherapy, or in last term chemical castration by androgen deprivation, have led to significant reduction of the incidence of PCa throughout the world. Worse prog…
View article: Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topology
Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topology Open
Over the course of the last decades, the continuous exposure of bacteria to antibiotics—at least in parts due to misprescription, misuse, and misdosing—has led to the widespread development of antimicrobial resistances. This development po…
View article: Inhibition of Candida glabrata Biofilm by Combined Effect of Dendritic Compounds and Amphotericin
Inhibition of Candida glabrata Biofilm by Combined Effect of Dendritic Compounds and Amphotericin Open
In the last decade, Candida glabrata has become an important emerging opportunistic pathogen not only because of the increase in nosocomial infections frequency but also because of its ability to form biofilms and its innate resistance to …
View article: The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes
The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes Open
Biomedical applications of gold nanoparticles (AuNPs) may be limited by their toxicological effects. Although surface-modified AuNPs can induce apoptosis, less is known about whether they can induce other types of cell death. Pyroptosis, a…
View article: Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF-7 Cells Cultured in 3D Spheroids
Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF-7 Cells Cultured in 3D Spheroids Open
Cationic dendrimers are effective carriers for the delivery of siRNA into cells; they can penetrate cell membranes and protect nucleic acids against RNase degradation. Two types of dendrimers (CBD-1 and CBD-2) and their complexes with pro-…
View article: Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers
Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers Open
Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and the appear…
View article: Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide
Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide Open
The UNAIDS objective for 2020 was 500,000 new HIV-1 infections per year; however, the latest annual reported data confirmed 1.7 million new HIV-1 infections in that year. Those data evidences the need for new prevention strategies and prop…
View article: The Antibacterial Effect of PEGylated Carbosilane Dendrimers on P. aeruginosa Alone and in Combination with Phage-Derived Endolysin
The Antibacterial Effect of PEGylated Carbosilane Dendrimers on P. aeruginosa Alone and in Combination with Phage-Derived Endolysin Open
The search for new microbicide compounds is of an urgent need, especially against difficult-to-eradicate biofilm-forming bacteria. One attractive option is the application of cationic multivalent dendrimers as antibacterials and also as ca…
View article: Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms
Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms Open
Combination of carbosilane dendritic structures and polyphenol to obtain new scavenging systems.
View article: Bacteria capture with magnetic nanoparticles modified with cationic carbosilane dendritic systems
Bacteria capture with magnetic nanoparticles modified with cationic carbosilane dendritic systems Open
Bacteria elimination from water sources is key to obtain drinkable water. Hence, the design of systems with ability to interact with bacteria and remove them from water is an attractive proposal. A diversity of polycationic macromolecules …
View article: Polyphenol content and antioxidant capacity of the Tarumá (Vitex cymosa) tree and the potential health benefits.
Polyphenol content and antioxidant capacity of the Tarumá (Vitex cymosa) tree and the potential health benefits. Open
Indigenous plants such as the Tarumá tree may have beneficial health properties through their bioactive compounds and antioxidant capacity. The objective of this study was to evaluate the nutritional composition, the phytochemical performa…
View article: Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson’s Disease Patient-Specific Dopamine Neurons
Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson’s Disease Patient-Specific Dopamine Neurons Open
Accumulation of misfolded α-synuclein (α-syn) is a hallmark of Parkinson's disease (PD) thought to play important roles in the pathophysiology of the disease. Dendritic systems, able to modulate the folding of proteins, have emerged as pro…
View article: Prospects of Cationic Carbosilane Dendronized Gold Nanoparticles as Non-viral Vectors for Delivery of Anticancer siRNAs siBCL-xL and siMCL-1
Prospects of Cationic Carbosilane Dendronized Gold Nanoparticles as Non-viral Vectors for Delivery of Anticancer siRNAs siBCL-xL and siMCL-1 Open
Cancer is one of the most important problems of modern medicine. At the present time, gene therapy has been developed against cancer, which includes the delivery of anticancer small interfering RNAs (siRNAs) directed at cancer proteins. Th…
View article: G2-S16 Polyanionic Carbosilane Dendrimer Can Reduce HIV-1 Reservoir Formation by Inhibiting Macrophage Cell to Cell Transmission
G2-S16 Polyanionic Carbosilane Dendrimer Can Reduce HIV-1 Reservoir Formation by Inhibiting Macrophage Cell to Cell Transmission Open
Human immunodeficiency virus (HIV-1) is still a major problem, not only in developing countries but is also re-emerging in several developed countries, thus the development of new compounds able to inhibit the virus, either for prophylaxis…