Rafael Roesler
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View article: Pediatric melanoma in Brazil: an analysis of mortality
Pediatric melanoma in Brazil: an analysis of mortality Open
View article: Delayed growth of SK-ES-1 Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1R
Delayed growth of SK-ES-1 Ewing sarcoma tumors associated with reduced expression and activity of Trk receptors, PI3K, and IGF1R Open
Ewing sarcoma (ES) is an aggressive childhood tumor. We have previously shown that tropomyosin receptor kinase (Trk) neurotrophin receptors regulate viability, and the pan-Trk and kinase inhibitor K252a restores sensitivity to chemotherapy…
View article: Mortality Trends in Pediatric Hepatoblastoma: A Brazilian and Global Perspective
Mortality Trends in Pediatric Hepatoblastoma: A Brazilian and Global Perspective Open
Background: Hepatoblastoma is a rare malignant liver tumor that accounts for 1–2% of pediatric cancers. Despite its low incidence, it is a significant cause of cancer-related mortality in early childhood. Methods: This ecological study ana…
View article: GABAergic Influences on Medulloblastoma
GABAergic Influences on Medulloblastoma Open
Medulloblastoma (MB) is the most common malignant brain tumor in children and typically arises in the cerebellum, likely due to disruptions in neuronal precursor development. The primary inhibitory neurotransmitter in the central nervous s…
View article: Melanotic neuroectodermal tumor of infancy: extra-axial lesion in the frontal midline of the skull – a case report
Melanotic neuroectodermal tumor of infancy: extra-axial lesion in the frontal midline of the skull – a case report Open
Introduction Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare tumor originating from neural crest cells, most often affecting infants, particularly in the head and neck region. Case Report The patient, a 4-month-old boy, present…
View article: Genetic variants associated with oral mucositis in pediatric patients with acute lymphoblastic leukemia and lymphoma undergoing chemotherapy.
Genetic variants associated with oral mucositis in pediatric patients with acute lymphoblastic leukemia and lymphoma undergoing chemotherapy. Open
View article: Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia
Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia Open
Background: Neurotrophins (NTs) are pivotal growth factors in cellular development and survival. Their precise implications in Acute Lymphoblastic Leukemia (ALL) remain unclear. Methods: Pediatric ALL samples (2011–2021) were analyzed from…
View article: Opposite patterns of association of <i>TWIST1</i> expression with patient survival in SHH and Group 4 medulloblastoma
Opposite patterns of association of <i>TWIST1</i> expression with patient survival in SHH and Group 4 medulloblastoma Open
Purpose Twist1 is a transcription factor that regulates embryonic development, stemness, and differentiation, and can also stimulate initiation of tumorigenesis in peripheral solid cancers. However, its role in central nervous system tumor…
View article: Porto Alegre Line predicts lenticulostriate arteries encasement and extent of resection in insular gliomas. A preliminary study
Porto Alegre Line predicts lenticulostriate arteries encasement and extent of resection in insular gliomas. A preliminary study Open
Object In insular glioma surgery, lenticulostriate arteries (LSTa) tumoral encasement increases neurological deficits risk despite intensive efforts to preserve the internal capsule's integrity. In this study, we focus on the LSTa relation…
View article: Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres Open
Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts pa…
View article: High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma
High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma Open
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via…
View article: Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres Open
Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts pa…
View article: Colesteatoma do ápex petroso: um achado atípico
Colesteatoma do ápex petroso: um achado atípico Open
Introduction: Cholesteatoma, although relatively rare, presents significant challenges in clinical practice. Despite decades of research, its cause remains complex and elusive. Objective: This review aimed to summarize key findings on the …
View article: Receptores de membrana GABRA5 são alvos moleculares na identificação de gliomas?
Receptores de membrana GABRA5 são alvos moleculares na identificação de gliomas? Open
Introduction: Gliomas are the most common primary tumors of the central nervous system. The majority are formed by glioblastomas, with high degrees of proliferation and invasion, with biological heterogeneity and little response to current…
View article: NRP1 como potencial alvo molecular para meduloblastoma
NRP1 como potencial alvo molecular para meduloblastoma Open
Introdução: Meduloblastoma é tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco cerebral, especialmente em crianças. Mesmo com avanços na terapia, a morbimortalidad…
View article: COLESTEATOMA DO ÁPEX PETROSO: UM RARO TUMOR
COLESTEATOMA DO ÁPEX PETROSO: UM RARO TUMOR Open
Introdução: O colesteatoma, embora relativamente raro, apresenta desafios significativos na prática clínica. Apesar de décadas de pesquisa, sua causa permanece complexa e evasiva. Objetivo: Esta revisão pretendeu resumir as principais desc…
View article: Cordoma da população pediátrica - um relato de caso
Cordoma da população pediátrica - um relato de caso Open
View article: O risco de radiocirurgia como tratamento primário para tumores supostamente benignos da base do crânio
O risco de radiocirurgia como tratamento primário para tumores supostamente benignos da base do crânio Open
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View article: Craniofaringioma na população pediátrica – ressecção total com abordagem pré-temporal
Craniofaringioma na população pediátrica – ressecção total com abordagem pré-temporal Open
View article: Astrocitoma intramedular na transição bulbo cervical em criança
Astrocitoma intramedular na transição bulbo cervical em criança Open
View article: Colesteatoma de Ápex Petroso ressecado por via retrolabiríntica – nota técnica de uma rara apresentação
Colesteatoma de Ápex Petroso ressecado por via retrolabiríntica – nota técnica de uma rara apresentação Open
View article: NRP1 COMO POTENCIAL ALVO MOLECULAR PARA MEDULOBLASTOMA
NRP1 COMO POTENCIAL ALVO MOLECULAR PARA MEDULOBLASTOMA Open
Introdução : Meduloblastoma é um tumor maligno, altamente agressivo e de rápido crescimento que surge no cerebelo ou no assoalho do quarto ventrículo e tronco cerebral, especialmente em crianças. Mesmo com os avanços na terapia, a morbimor…
View article: Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma
Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma Open
Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-…
View article: RECEPTORES DE MEMBRANA GABRA5 SÃO ALVOS MOLECULARES NA IDENTIFICAÇÃO DE GLIOMAS?
RECEPTORES DE MEMBRANA GABRA5 SÃO ALVOS MOLECULARES NA IDENTIFICAÇÃO DE GLIOMAS? Open
Introdução: Gliomas são os tumores primários mais comuns do sistema nervoso central e a maioria é formada por glioblastomas, com graus elevados de proliferação e invasão, com heterogeneidade biológica e pouca resposta aos tratamentos atuai…
View article: Gene Expression of GABAA Receptor Subunits and Association with Patient Survival in Glioma
Gene Expression of GABAA Receptor Subunits and Association with Patient Survival in Glioma Open
Rapid neuronal inhibition in the brain is mediated by γ-aminobutyric acid (GABA) activation of GABAA receptors. The GABRA5 gene, which encodes the α5 subunit of the GABAA receptor, has been implicated in an aggressive subgroup of medullobl…
View article: Gene Expression of CSF3R/CD114 Is Associated with Poorer Patient Survival in Glioma
Gene Expression of CSF3R/CD114 Is Associated with Poorer Patient Survival in Glioma Open
Gliomas comprise most cases of central nervous system (CNS) tumors. Gliomas afflict both adults and children, and glioblastoma (GBM) in adults represents the clinically most important type of malignant brain cancer, with a very poor progno…
View article: Trk Inhibition Reduces Tumorsphere Formation and Changes Expression of Stemness Markers in SK-ES-1 Ewing Sarcoma Cells
Trk Inhibition Reduces Tumorsphere Formation and Changes Expression of Stemness Markers in SK-ES-1 Ewing Sarcoma Cells Open
Introduction: Ewing sarcoma (ES) is a highly aggressive type of childhood cancer characterized by a chromosomal translocation resulting in fusions between the gene encoding EWS RNA Binding Protein 1 (EWSR1) and one gene of the ETS family, …
View article: Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma Open
Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine methyltransferase 2 (G9a, EHMT2), which is encoded by the G9a (Ehmt2) gene, as …
View article: The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer
The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer Open
Neuropilins are transmembrane glycoproteins that regulate developmental processes in the nervous system and other tissues. Overexpression of neuropilin-1 (NRP1) occurs in many solid tumor types and, in several instances, may predict patien…
View article: Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR Open
Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with distinct biological features and prognosis. Currently available therapy often results in poor long-term quality of life f…