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Dual transcriptomic profiling of <i>Staphylococcus aureus</i> endocarditis in a porcine model reveals strong parallels with human infection Open

Begoña García, Aritza Conty, Amaya Fernández‐Celis, Daniel Mouzo, Carmen Gil , et al. · 2025

Understanding the intricate interactions between Staphylococcus aureus and valve cells during the course of endocarditis is crucial for developing more effective treatments for an infection that has a mortality rate exceeding 30%. To inves…

EACTS Expert Consensus Statement on the Ross Procedure in Adult Patients Open

Jan Vojáček, Ján Gofus, Martin Andreas, Joseph E. Bavaria, Denis Berdajs , et al. · 2025

The Ross procedure, which involves replacing a diseased aortic valve with the patient’s own pulmonary valve (pulmonary autograft), has gained renewed attention in adult patients due to mounting evidence of excellent long-term outcomes. Wit…

2025 ESC/EACTS Guidelines for the management of valvular heart disease Open

Fabien Praz, Michael A. Borger, Jonas Lanz, Mateo Marín-Cuartas, Ana Abreu , et al. · 2025

International audience

Use of complementary electrocardiogram-gated cardiac computed tomography in the assessment of aortic valve repairability: a pilot study Open

Valentina Mescola, Virginia Álvarez Asiaín, Javier de Diego Candela, Adalberto Olivera Echeverría, Francisco Javier Ampudia‐Blasco , et al. · 2025

OBJECTIVES In young patients with type I/II aortic regurgitation, the feasibility of aortic valve (AV) repair has been traditionally evaluated with echocardiography. We evaluate electrocardiogram (ECG)-gated cardiac computed tomography as …

The Presence of Adipose Tissue in Aortic Valves Influences Inflammation and Extracellular Matrix Composition in Chronic Aortic Regurgitation Open

Alba Sádaba, Mattie Garaikoetxea, Carolina Tiraplegui, Susana San-Ildefonso-García, Miriam Goñi-Olóriz , et al. · 2025

Adipose tissue is present in aortic valves (AVs). Valve interstitial cells (VICs) could differentiate into adipogenic lineages. We here characterize whether the presence of adipose tissue in the AV influences inflammation and extracellular…

Long-term mortality after coronary surgery in women patients depend on diabetes and age Open

Víctor Dayan, J.A. Montero, M.D. Jiménez Hernández, Carolina Sosa, Santiago Cubas , et al. · 2025

OBJECTIVES There is general consensus of the higher short-term risk in women after coronary artery bypass grafts (CABG), nonetheless, long-term survival is a matter of debate. We aimed to compare in a national database with over 10 years o…

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

Objective: Globally significant variation in treatment and course of heart valve disease (HVD) exists, and outcome measurement is procedure focused instead of patient focused. This article describes the development of a patient-related (In…

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

Through a unique collaborative effort between patients and cardiology and cardiothoracic surgery societies, a standard set of measures for HVD was developed. This dataset focuses on outcome measurement regardless of treatment, moving from …

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

Through a unique collaborative effort between patients and cardiology and cardiothoracic surgery societies, a standard set of measures for HVD was developed. This dataset focuses on outcome measurement regardless of treatment, moving from …

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

BACKGROUND: Globally significant variation in treatment and course of heart valve disease (HVD) exists, and outcome measurement is procedure focused instead of patient focused. This article describes the development of a patient-related (I…

The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

Background Globally significant variation in treatment and course of heart valve disease (HVD) exists, and outcome measurement is procedure focused instead of patient focused. This article describes the development of a patient-related (In…

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes Open

Emmanuel Lansac, Kevin M. Veen, Andria Joseph, Paula Blancarte Jaber, Frieda Sossi , et al. · 2025

BACKGROUND Globally significant variation in treatment and course of heart valve disease (HVD) exists, and outcome measurement is procedure focused instead of patient focused. This article describes the development of a patient-related (In…

Chemerin is a new sex-specific target in aortic stenosis concomitant with diabetes regulated by the aldosterone/mineralocorticoid receptor axis Open

Miriam Goñi-Olóriz, Mattie Garaikoetxea, Susana San Ildefonso-García, Amaya Fernández‐Celis, Paula Castillo , et al. · 2025

Chemerin is upregulated in AV of male diabetic patients with AS, correlating with valve degeneration markers and influenced by Aldo/MR activation. This highlights chemerin as a sex-specific target for AS therapy.

Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation Open

Carolina Tiraplegui, Mattie Garaikoetxea, Alba Sádaba, Susana San Ildefonso-García, Miriam Goñi-Olóriz , et al. · 2025

The pathogenesis of chronic aortic regurgitation (AR) is different in male and female. Female patients with AR showed less aortic valve inflammation and collagen accumulation as compared with male. Valvular cells from female patients secre…

Manejo del aparato subvalvular mitral en pacientes con miocardiopatía hipertrófica obstructiva Open

Valentina Mescola, Juan B. Grau-Álvaro, Virginia Álvarez-Asiáin, Luis Jiménez-Alfaro, Félix Gómez-Blasco , et al. · 2024

Resumen: Introducción: En la miocardiopatía hipertrófica obstructiva, a la obstrucción del tracto de salida concurre, además de la hipertrofia, la insuficiencia mitral dinámica. Esta depende del movimiento sistólico anterior del velo anter…

Human endocarditis on prosthetic valves due to Bartonella vinsonii subsp. berkhoffii Open

Iñaki Beguiristain, Aitziber Aguinaga, Miguel Fernández-Huerta, Rafael Sádaba, Carmen Ezpeleta · 2024

Bartonella spp. infections are increasingly recognized as causes of zoonotic diseases. One of the most severe infections caused by Bartonella spp. is infective endocarditis, predominantly affecting individuals with underlying valvular hear…

2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP Open

Filip Casselman, Marcus D. Lancé, Aamer Ahmed, Alice Ascari, Juan Blanco-Morillo , et al. · 2024

2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP Open

Filip Casselman, Marcus D. Lancé, Aamer Ahmed, Alice Ascari, Juan Blanco-Morillo , et al. · 2024

Clinical practice guidelines consolidate and evaluate all pertinent evidence available at their time of formulation on a specific topic, the goal being to assist physicians in determining the most effective management strategies for patien…

Conflicts of interest in clinical practice: lessons learned from cardiovascular medicine. Open

Daniele Ronco, Arthur M. Albuquerque, Mateo Marín-Cuartas, Amédéo Anselmi, Rafael Sádaba , et al. · 2024

Cardiovascular diseases represent a major burden worldwide, and clinical trials are critical to define treatment improvements. Since various conflicts of interest (COIs) may influence trials at multiple levels, cardiovascular research repr…

TREATMENT OF SEVERE AORTIC STENOSIS IN PATIENTS WITH LOW SURGICAL RISK Open

Rafael Sádaba, Valentina Mescola · 2024

Following the first implantation of a percutaneous valve in 2002, two of the leading manufacturers of biological valve prostheses developed percutaneous aortic platforms, which have promoted transcatheter aortic valve implantation (TAVI) a…

TRATAMIENTO DE LA ESTENOSIS AÓRTICA GRAVE EN PACIENTES DE BAJO RIESGO QUIRÚRGICO Open

Rafael Sádaba, Valentina Mescola · 2024

Tras el primer implante de una prótesis valvular percutánea en 2002, dos de los principales fabricantes de prótesis valvulares biológicas desarrollaron sendas plataformas percutáneas para posición aórtica, que han impulsado al implante val…

Benefits of coronary artery bypass grafting over percutaneous coronary intervention in left main disease: the strength of the evidence Open

Stefano Urso, Rafael Sádaba, Víctor Dayan · 2024

SEX-RELATED SIGNALLING OF ALDOSTERONE/MINERALOCORTICOID RECEPTOR PATHWAY IN CALCIFIC AORTIC STENOSIS Open

Lara Matilla, Eva Jover, Mattie Garaikoetxea, Vanessa Arrieta, Amaia García-Peña , et al. · 2024

BACKGROUND AND PURPOSE: There are clear sex differences in the pathophysiology of aortic valve (AV) calcification in aortic stenosis (AS) patients. However, the molecular and cellular mechanisms underlying such sex differences have not bee…

Outcomes after surgical revascularization in diabetic patients Open

Martín Misfeld, Sigrid Sandner, Etem Caliskan, Andreas Böning, José I. Aramendi , et al. · 2024

OBJECTIVES Patients with diabetes mellitus (DM) undergoing coronary artery bypass grafting (CABG) have been repeatedly demonstrated to have worse clinical outcomes compared to patients without DM. The objective of this study was to evaluat…

Sex-specific role of galectin-3 in aortic stenosis Open

Lara Matilla, Ernesto Martín‐Núñez, Mattie Garaikoetxea, Adela Navarro, Ibai Tamayo , et al. · 2023

Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach Open

Ernesto Martín‐Núñez, Miriam Goñi-Olóriz, Lara Matilla, Mattie Garaikoetxea, Laura Mouriño-Álvarez , et al. · 2023

Background Diabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not clear. Moreover, whether DM contributes to clinically relevant sex-differences in AS is un…

Revascularization of low-surgical risk patients with disease of the left main coronary artery: a fresh look at the evidence Open

Colin Baigent, Rafael Sádaba · 2023

This editorial refers to ‘2022 joint ESC/EACTS review of the 2018 guideline recommendations on the revascularization of left main coronary artery disease in patients at low surgical risk and anatomy suitable for PCI or CABG’, by R.A.

Revascularization of low-surgical risk patients with disease of the left main coronary artery: a fresh look at the evidence Open

Colin Baigent, Rafael Sádaba · 2023

Graphical AbstractOpen in new tabDownload slideCABG, coronary artery bypass grafting; DES, drug-eluting stent; EACTS, European Association for Cardio-Thoracic Surgery; ESC, European Society of Cardiology; EXCEL, Evaluation of XIENCE vs. Co…

EXPECTATIONS FOR THE FUTURE OF CARDIOVASCULAR SURGERY Open

Rafael Sádaba · 2023

Recently, I had the opportunity to watch a video, Surgical Correction ofDissecting Aneurysm of Ascending Aorta (Baylor College of Medicine, 1963),which made me reflect on the evolution of cardiovascular surgery in recentdecades and, at the…

Expectativas de futuro en la cirugía cardiovascular Open

Rafael Sádaba · 2023

Recently, I had the opportunity to watch a video, Surgical Correction ofDissecting Aneurysm of Ascending Aorta (Baylor College of Medicine, 1963),which made me reflect on the evolution of cardiovascular surgery in recentdecades and, at the…

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