Rafeeq Muhammed
YOU?
Author Swipe
View article: Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity Open
Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited …
View article: ‘We need to make “shit” sexy’ a qualitative study exploring treatment adherence in adolescents with inflammatory bowel disease
‘We need to make “shit” sexy’ a qualitative study exploring treatment adherence in adolescents with inflammatory bowel disease Open
Background: Adolescents with inflammatory bowel disease (IBD) are faced with the complexities of acquiring self-management behaviours at a time when they are also navigating developmental challenges associated with adolescence. To d…
View article: Hypoxic ischemic encephalopathy: Incidence, risk factors & mortality rate in Al- Yarmuk teaching hospital
Hypoxic ischemic encephalopathy: Incidence, risk factors & mortality rate in Al- Yarmuk teaching hospital Open
View article: Interventions for improving treatment adherence in young people with inflammatory bowel disease (IBD): A systematic review of behaviour change theory and behaviour change techniques
Interventions for improving treatment adherence in young people with inflammatory bowel disease (IBD): A systematic review of behaviour change theory and behaviour change techniques Open
Treatment adherence is important but challenging for young people with inflammatory bowel disease (IBD). Behavioural interventions may support adherence, leading to improved condition management. This review aimed to evaluate interventions…
View article: A Self-led Self-management Intervention Supporting Teens with IBD (ASSIST-IBD): protocol for a feasibility study of a novel digital treatment adherence intervention
A Self-led Self-management Intervention Supporting Teens with IBD (ASSIST-IBD): protocol for a feasibility study of a novel digital treatment adherence intervention Open
Introduction Treatment non-adherence is common in young people with inflammatory bowel disease (IBD), yet support is lacking. A self-led self-management intervention supporting teens with IBD (ASSIST-IBD) is a new theory-based digital trea…
View article: Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children
Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children Open
The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn’s disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and …
View article: Faecal volatile organic compounds differ according to inflammatory bowel disease sub‐type, severity, and response to treatment in paediatric patients
Faecal volatile organic compounds differ according to inflammatory bowel disease sub‐type, severity, and response to treatment in paediatric patients Open
Background Faecal volatile organic compounds (VOCs) differ with disease sub‐type and activity in adults with established inflammatory bowel disease (IBD) taking therapy. Objective To describe patterns of faecal VOCs in children newly prese…
View article: P056 Cereal intake and diet-related microbial metabolites in faeces associate with recurrence of gut inflammation during food reintroduction in children with Crohn’s disease treated with exclusive enteral nutrition; iPENS a multicentre, prospective study
P056 Cereal intake and diet-related microbial metabolites in faeces associate with recurrence of gut inflammation during food reintroduction in children with Crohn’s disease treated with exclusive enteral nutrition; iPENS a multicentre, prospective study Open
Background Faecal calprotectin (FCAL) rises rapidly in children with Crohn’s disease (CD) following treatment with exclusive enteral nutrition (EEN). We aimed to identify clinical, dietary and diet-related microbial metabolites which assoc…
View article: P080 High faecal pH and low total microbial load associate with normalisation of faecal calprotectin in children with Crohn’s disease treated with exclusive enteral nutrition; results from iPENS, a multicentre, prospective study
P080 High faecal pH and low total microbial load associate with normalisation of faecal calprotectin in children with Crohn’s disease treated with exclusive enteral nutrition; results from iPENS, a multicentre, prospective study Open
Background Exclusive enteral nutrition (EEN) is a main therapy for active Crohn’s disease (CD) in children, but normalisation of faecal calprotectin (FCAL) varies among patients, even in those who enter clinical remission. To better unders…
View article: Improved Clinical Outcomes With Early Anti-Tumour Necrosis Factor Alpha Therapy in Children With Newly Diagnosed Crohn’s Disease: Real-world Data from the International Prospective PIBD-SETQuality Inception Cohort Study
Improved Clinical Outcomes With Early Anti-Tumour Necrosis Factor Alpha Therapy in Children With Newly Diagnosed Crohn’s Disease: Real-world Data from the International Prospective PIBD-SETQuality Inception Cohort Study Open
Background and Aims Treatment guidelines for paediatric Crohn’s disease [CD] suggest early use of anti-tumour necrosis factor alpha [anti-TNFα] in high-risk individuals. The aim is to evaluate the effect of early anti-TNF in a real-world c…
View article: Young persons and healthcare professionals experience of virtual gastroenterology consultations: a multicentre survey conducted during the COVID-19 pandemic
Young persons and healthcare professionals experience of virtual gastroenterology consultations: a multicentre survey conducted during the COVID-19 pandemic Open
Objective To explore Young Persons (YP) and healthcare professionals (HCP) experiences of virtual consultations (VC) and establish whether developmentally appropriate healthcare can be delivered virtually. Method YP and HCP questionnaire s…
View article: Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study
Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study Open
View article: Inflammatory bowel disease patient‐reported quality assessment should drive service improvement: a national survey of <scp>UK IBD</scp> units and patients
Inflammatory bowel disease patient‐reported quality assessment should drive service improvement: a national survey of <span>UK IBD</span> units and patients Open
Summary Background Healthcare service provision in inflammatory bowel disease (IBD) is often designed to meet targets set by healthcare providers rather than those of patients. It is unclear whether this meets the needs of patients, as ass…
View article: Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab Open
View article: The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry
The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry Open
Background and Aims Guidelines regarding thromboprophylaxis for venous thromboembolisms [VTEs] in children with inflammatory bowel disease [IBD] are based on limited paediatric evidence. We aimed to prospectively assess the incidence of VT…
View article: P129 IBD care in the UK: A comprehensive, novel service assessment with feedback from 10,222 patients and 166 NHS organisations to inform a vision for quality improvement
P129 IBD care in the UK: A comprehensive, novel service assessment with feedback from 10,222 patients and 166 NHS organisations to inform a vision for quality improvement Open
Background The IBD Benchmarking Tool, comprising an online Service Self-Assessment and Patient Survey, has provided a unique and comprehensive picture of Inflammatory Bowel Disease (IBD) care across the UK. The aim was to evaluate current …
View article: O1 Faecal volatile organic compounds in paediatric inflammatory bowel disease
O1 Faecal volatile organic compounds in paediatric inflammatory bowel disease Open
Faecal volatile organic compounds (VOCs) result from the metabolism of the intestinal mucosa, gut microbiota and the environment. Profiling of faecal VOCs in children with different IBD sub-types and disease distribution and activity may s…
View article: O18 IBD care in 2020: results from the first IBD UK patient and service benchmarking tool
O18 IBD care in 2020: results from the first IBD UK patient and service benchmarking tool Open
Introduction Aligned to the 2019 IBD Standards, IBD UK developed a national Benchmarking Tool comprising a Service Self-Assessment for healthcare professionals and a Patient Survey. The aim was to qualify current local service performance …
View article: P85 Faecal volatile organic compounds in paediatric inflammatory bowel disease
P85 Faecal volatile organic compounds in paediatric inflammatory bowel disease Open
Faecal volatile organic compounds (VOCs) result from the metabolism of the intestinal mucosa, gut microbiota and the environment. Faecal VOCs may provide novel insights into the pathogenesis of gastrointestinal disorders. Method We assess…
View article: A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease
A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease Open
INTRODUCTION: Thetanix (gastroresistant capsules containing lyophilized Bacteroides thetaiotaomicron ) is a live biotherapeutic, under development for Crohn's disease, that antagonizes transcription factor nuclear factor kappa B, reducing …
View article: Characterisation of fasted state gastric and intestinal fluids collected from children
Characterisation of fasted state gastric and intestinal fluids collected from children Open
View article: The quality of operation theatre notes in the orthopaedic department of Kenyatta National Hospital
The quality of operation theatre notes in the orthopaedic department of Kenyatta National Hospital Open
Background: Well written theatre operation notes are important not only as a medico legal requirement but also useful for clinical research. This study assessed the quality of orthopaedic theatre notes at Kenyatta National Hospital, the la…
View article: Consensus standards of healthcare for adults and children with inflammatory bowel disease in the UK
Consensus standards of healthcare for adults and children with inflammatory bowel disease in the UK Open
Objective Symptoms and clinical course during inflammatory bowel disease (IBD) vary among individuals. Personalised care is therefore essential to effective management, delivered by a strong patient-centred multidisciplinary team, working …
View article: Highlights from the literature
Highlights from the literature Open
The CELIPREV (Celiac Disease Risk Prevalence and natural history of potential celiac disease in at family-risk infants prospectively investigated from birth) study1 prospectively followed up 553 children in Italy from birth with coeliac di…
View article: Reduced skeletal muscle protein balance in paediatric Crohn's disease
Reduced skeletal muscle protein balance in paediatric Crohn's disease Open
View article: Highlights from the literature: inflammatory bowel disease
Highlights from the literature: inflammatory bowel disease Open
CALM trial compared endoscopic and clinical outcomes in patients with moderate to severe Crohn’s disease who were managed with a tight control algorithm, using clinical symptoms and biomarkers, versus patients managed with a clinical manag…
View article: OTH-003 Paediatric crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feeding
OTH-003 Paediatric crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feeding Open
Introduction Sarcopenia is common in active Crohn's disease (CD) and still prevalent in remission. This can lead to fatigue, physical inactivity and poor quality of life but the aetiology is unclear. We aimed to investigate the association…
View article: Improved Medical Treatment and Surgical Surveillance of Children and Adolescents with Ulcerative Colitis in the United Kingdom
Improved Medical Treatment and Surgical Surveillance of Children and Adolescents with Ulcerative Colitis in the United Kingdom Open
A third of children were not responsive to steroids, and a quarter of these were treated with anti-TNFalpha. Colectomy was required in 41/298 (13.7%) of all admissions. Our national audit program indicates effectiveness of actions taken to…
View article: P019 Paediatric Crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feeding
P019 Paediatric Crohn’s disease patients in remission have a reduced skeletal muscle protein balance after feeding Open
Sarcopenia is common in active Crohn’s disease (CD) and still prevalent in remission. This can lead to fatigue, physical inactivity and poor quality of life. The aetiology is unclear. Low levels of physical activity, inability to respond t…
View article: P194 Upper GI endoscopy is an expensive accessory investigation in the diagnosis of Crohn’s disease in children
P194 Upper GI endoscopy is an expensive accessory investigation in the diagnosis of Crohn’s disease in children Open
ESPGHAN Porto revised criteria recommends upper gastrointestinal endoscopy (OGD) and ileo-colonoscopy with small bowel imaging for all suspected patients with Crohn’s disease (CD).OGD is recommended with an aim to improve the diagnostic yi…