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View article: DNA methylation analysis with nasal brushing for early diagnosis of sino-nasal malignant tumours
DNA methylation analysis with nasal brushing for early diagnosis of sino-nasal malignant tumours Open
Sinonasal tumors are rare entities presenting with non-specific symptoms, therefore being often mis-interpreted. The aim of the present study was to evaluate if the 13-gene DNA Methylation assay for early cancer detection already assessed …
View article: GBA1 status and sex impact on depression severity and progression in Parkinson’s Disease
GBA1 status and sex impact on depression severity and progression in Parkinson’s Disease Open
GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex impact occurrence and progression of depres…
View article: The Complex Interplay Between Sleep and Healthy Aging: A Scoping Review
The Complex Interplay Between Sleep and Healthy Aging: A Scoping Review Open
View article: Visuospatial performance and its neural substrates in Dementia with Lewy Bodies during a pointing task
Visuospatial performance and its neural substrates in Dementia with Lewy Bodies during a pointing task Open
Dementia with Lewy Bodies (DLB) is characterized by motor and cognitive deficits that often overlap with other neurodegenerative disorders, complicating its diagnosis. This study combined linear mixed-effects modeling and machine learning …
View article: Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease
Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease Open
This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient jo…
View article: DARE to wear: digital health promotion and disease prevention using wearable devices
DARE to wear: digital health promotion and disease prevention using wearable devices Open
Global healthcare systems are under increasing strain to ensure long-term sustainability, necessitating a fundamental transition towards proactive, preventive healthcare strategies. Wearable sensor technologies are uniquely positioned to f…
View article: Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study
Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study Open
Background: The androgen receptor (AR) is a ligand-dependent transcription factor of the nuclear steroid receptor superfamily, implicated in the pathogenesis of various solid tumors. The AR gene, located on chromosome Xq11–12, is accompani…
View article: The remote administration of the uniform data set neuropsychological test battery (I-UDSNB) Italian version: normative data
The remote administration of the uniform data set neuropsychological test battery (I-UDSNB) Italian version: normative data Open
The availability of remotely administered neuropsychological batteries is crucial to provide access to care in extraordinary situations, e.g., the recent pandemic, and for individuals with reduced mobility. Here we present the normative da…
View article: Clinical course and management challenges in Lafora disease: a narrative analysis in an Apulian cohort
Clinical course and management challenges in Lafora disease: a narrative analysis in an Apulian cohort Open
Background Lafora disease (LD) is an ultra-rare, autosomal recessive neurodegenerative disorder characterized by the accumulation of Lafora bodies in the brain, leading to drug-resistant epilepsy, myoclonus, progressive dementia, and cereb…
View article: Correction to: Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept
Correction to: Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept Open
View article: Visuospatial performance during a pointing task in Dementia with Lewy Bodies.
Visuospatial performance during a pointing task in Dementia with Lewy Bodies. Open
View article: Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept
Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept Open
These preliminary findings provide exploratory support for the hypothesis that inhibitory rTMS can induce functional and structural reorganization of the motor network. The combined use of rs-fMRI and DTI highlights the potential of NICP a…
View article: DISARM++: Beyond scanner-free harmonization
DISARM++: Beyond scanner-free harmonization Open
Harmonization of T1-weighted MR images across different scanners is crucial for ensuring consistency in neuroimaging studies. This study introduces a novel approach to direct image harmonization, moving beyond feature standardization to en…
View article: Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity
Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity Open
Borderline personality disorder (BPD) is is a type B personality disorder primarily characterized by a pattern of unstable interpersonal relationships, a distorted self-concept, and intense emotional reactions, associated with extreme and …
View article: Sensori-motor Network Pre-habilitation by Low-Frequency Repetitive Transcranial Magnetic Stimulation. A Proof-of-Concept
Sensori-motor Network Pre-habilitation by Low-Frequency Repetitive Transcranial Magnetic Stimulation. A Proof-of-Concept Open
Background Tumors involving motor-eloquent brain regions pose a significant surgical challenge, as maximizing resection while preserving motor function requires a delicate balance. Neuromodulation-induced cortical prehabilitation (NICP) ha…
View article: Pons metabolite alterations in narcolepsy type 1
Pons metabolite alterations in narcolepsy type 1 Open
View article: Microbiota–Gut–Brain Axis: Mass-Spectrometry-Based Metabolomics in the Study of Microbiome Mediators—Stress Relationship
Microbiota–Gut–Brain Axis: Mass-Spectrometry-Based Metabolomics in the Study of Microbiome Mediators—Stress Relationship Open
The microbiota–gut–brain axis is a complex bidirectional communication system that involves multiple interactions between intestinal functions and the emotional and cognitive centers of the brain. These interactions are mediated by molecul…
View article: Functional connectivity and metabolic brain alterations in sleepwalkers
Functional connectivity and metabolic brain alterations in sleepwalkers Open
Objective Disorders of arousal (DoA) are characterized by an intermediate state between wakefulness and deep sleep, leading to incomplete awakenings from NREM sleep. Multimodal studies have shown subtle neurophysiologic alterations even du…
View article: Blood neurofilament light chain and S100B as biomarkers of neurological involvement and functional prognosis in COVID-19: a multicenter study
Blood neurofilament light chain and S100B as biomarkers of neurological involvement and functional prognosis in COVID-19: a multicenter study Open
View article: Sensori-motor Network Pre-habilitation by Low-Frequency Repetitive Transcranial Magnetic Stimulation
Sensori-motor Network Pre-habilitation by Low-Frequency Repetitive Transcranial Magnetic Stimulation Open
View article: Best Abstract: Intraventricular Involvement in Poor-Grade Aneurysmal Subarachnoid Hemorrhage: Predictors of Mortality and Long-Term Disability
Best Abstract: Intraventricular Involvement in Poor-Grade Aneurysmal Subarachnoid Hemorrhage: Predictors of Mortality and Long-Term Disability Open
View article: Fully automated pipeline for the fiber tractography of the anterior optic pathway in patients with sellar and parasellar tumors and analysis of the microstructural alterations
Fully automated pipeline for the fiber tractography of the anterior optic pathway in patients with sellar and parasellar tumors and analysis of the microstructural alterations Open
View article: Structural and functional frontal‐executive dysfunction in patients with isolated REM sleep behaviour disorder
Structural and functional frontal‐executive dysfunction in patients with isolated REM sleep behaviour disorder Open
Background Isolated REM Sleep Behavior Disorder (iRBD) is a well‐recognized prodromal state of an underlying α‐synucleinopathy, occurring several years before an overt neurodegenerative disorder becomes fully manifest. iRBD has been relate…
View article: Detection of Brain-Derived Cell-Free DNA in Plasma
Detection of Brain-Derived Cell-Free DNA in Plasma Open
Background: Neuronal loss is a major pathological feature of neurodegenerative diseases. The analysis of plasma cell-free DNA (cfDNA) is an emerging approach to track cell death events in a minimally invasive way and from inaccessible area…
View article: Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario
Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario Open
The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared to manual recording. Nevertheless, the potential of the information contained within medical records remains large…
View article: Multiparametric MRI dataset for susceptibility-based radiomic feature extraction and analysis
Multiparametric MRI dataset for susceptibility-based radiomic feature extraction and analysis Open
View article: Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease
Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease Open
View article: Generalizing the Enhanced-Deep-Super-Resolution Neural Network to Brain MR Images: A Retrospective Study on the Cam-CAN Dataset
Generalizing the Enhanced-Deep-Super-Resolution Neural Network to Brain MR Images: A Retrospective Study on the Cam-CAN Dataset Open
The Enhanced-Deep-Super-Resolution (EDSR) model is a state-of-the-art convolutional neural network suitable for improving image spatial resolution. It was previously trained with general-purpose pictures and then, in this work, tested on b…
View article: The Contribution of Vessel Wall Magnetic Resonance Imaging to the Diagnosis of Primary and Secondary Central Nervous System Vasculitis
The Contribution of Vessel Wall Magnetic Resonance Imaging to the Diagnosis of Primary and Secondary Central Nervous System Vasculitis Open
Background: To describe high-resolution brain vessel wall MRI (VW-MRI) patterns and morphological brain findings in central nervous system (CNS) vasculitis patients. Methods: Fourteen patients with confirmed CNS Vasculitis from two tertiar…
View article: Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer’s Disease
Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer’s Disease Open
Background: Being able to differentiate mild cognitive impairment (MCI) patients who would eventually convert (MCIc) to Alzheimer’s disease (AD) from those who would not (MCInc) is a key challenge for prognosis. Objective: This study aimed…