Raffaella Isola
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View article: Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells
Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells Open
Plastic compounds released into the environment can be accumulated in human tissues causing various health issues. It has been demonstrated that Bisphenol A (BPA), widely used in polycarbonate plastics and food packaging, can accumulate in…
View article: Metabolic response to an acute bout of mild dynamic exercise performed under normobaric moderate hypoxia: A NMR-based metabolomics study
Metabolic response to an acute bout of mild dynamic exercise performed under normobaric moderate hypoxia: A NMR-based metabolomics study Open
The combination of hypoxia and exercise offers significant potential benefits for non-athletic individuals, particularly in clinical and rehabilitation settings. Personalized hypoxic exercise programs can be tailored to improve cardiovascu…
View article: Prostate‐specific antigen: An unfamiliar protein in the human salivary glands
Prostate‐specific antigen: An unfamiliar protein in the human salivary glands Open
Objectives The presence of prostate‐specific antigen (PSA) in saliva and salivary glands has been reported. Nevertheless, its release pathway in these glands remains to be elucidated. Here, we showed PSA subcellular distribution focusing o…
View article: Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia
Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia Open
The use of hypoxic devices among athletes who train in normobaric hypoxia has become increasingly popular; however, the acute effects on heart and brain metabolism are not yet fully understood. This study aimed to investigate the mitochond…
View article: Melatonin ultrastructural localization in mitochondria of human salivary glands
Melatonin ultrastructural localization in mitochondria of human salivary glands Open
The hormone melatonin was initially believed to be synthesized exclusively by the pineal gland and the enterochromaffin cells, but nowadays its production and distribution were observed in several other tissues and organs. Among others, th…
View article: Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males
Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males Open
Hemodynamic changes during exercise in acute hypoxia (AH) have not been completely elucidated. The present study aimed to investigate hemodynamics during an acute bout of mild, dynamic exercise during moderate normobaric AH. Twenty-two phy…
View article: Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice
Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice Open
AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis under conditions of energy stress. Though heart is one of the most energy requiring organs and depends on a perfect match of energy supply with high and fluctuati…
View article: STZ‐diabetic rat heart maintains developed tension amplitude by increasing sarcomere length and crossbridge density
STZ‐diabetic rat heart maintains developed tension amplitude by increasing sarcomere length and crossbridge density Open
New Findings What is the central question of this study? In the papillary muscle from type I diabetic rats, does diabetes‐associated altered ventricular function result from changes of acto‐myosin interactions and are these modifications a…
View article: Reactivity of human labial glands in response to cevimeline treatment
Reactivity of human labial glands in response to cevimeline treatment Open
Among the pathologies affecting the salivary glands, the Sjögren's syndrome (SS), an autoimmune disease, causes progressive destruction of the glandular tissue. The effect of SS is particularly evident on the labial glands and the morpholo…
View article: The Role of Lipid Composition in the Sensory Attributes and Acceptability of the Salted and Dried Mullet Roes (Bottarga): A Study in Human and Animal Models
The Role of Lipid Composition in the Sensory Attributes and Acceptability of the Salted and Dried Mullet Roes (Bottarga): A Study in Human and Animal Models Open
A taste component is implicated in the oro-sensory detection of dietary lipids and free fatty acids seem to be involved in fatty food recognition. Bottarga, the salted and semi-dried ovary product of mullet (Mugil spp.), is a rich-fat food…
View article: Suitability of the thawed algae for transmission electron microscopy study: Ultrastructural investigation on <i>Coccomyxa melkonianii</i><scp>SCCA</scp> 048
Suitability of the thawed algae for transmission electron microscopy study: Ultrastructural investigation on <i>Coccomyxa melkonianii</i><span>SCCA</span> 048 Open
Morphological and ultrastructural investigations are crucial for the identification and characterization of species such as microalgae, microorganisms that greatly change their morphology and physiology during their life cycle. Transmissio…
View article: Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2WD40 Genetic Model of Parkinson’s Disease
Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2WD40 Genetic Model of Parkinson’s Disease Open
The search for new disease-modifying drugs for Parkinson's disease (PD) is a slow and highly expensive process, and the repurposing of drugs already approved for different medical indications is becoming a compelling alternative option for…
View article: The dietary flavonoid eupatilin attenuates<i>in vitro</i>lipid peroxidation and targets lipid profile in cancer HeLa cells
The dietary flavonoid eupatilin attenuates<i>in vitro</i>lipid peroxidation and targets lipid profile in cancer HeLa cells Open
Eupatilin, a dietary flavonoid, is an antioxidant agent against membrane lipid oxidative damage and induces cytotoxicity, apoptosis and abnormal mitosis, affecting lipid profile and mitochondrial potential in cancer HeLa cells.
View article: Melatonin release by exocytosis in the rat parotid gland
Melatonin release by exocytosis in the rat parotid gland Open
Several beneficial effects on oral health are ascribed to melatonin. Due to its lipophilic nature, non‐protein‐bound circulating melatonin is usually thought to enter the saliva by passive diffusion through salivary acinar gland cells. Rec…
View article: Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands
Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands Open
Recently we reported on the detailed localization of melatonin (and its receptors) in human salivary glands, revealing that serous cells are able to store and secrete melatonin into saliva. Since we found that type 2 diabetic patients disp…
View article: Marked Differences in the Submandibular Salivary Proteome between Sardinian Alcohol-Preferring and Sardinian Alcohol-Non Preferring Rats Revealed by an Integrated Top-Down–Bottom-Up Proteomic Platform
Marked Differences in the Submandibular Salivary Proteome between Sardinian Alcohol-Preferring and Sardinian Alcohol-Non Preferring Rats Revealed by an Integrated Top-Down–Bottom-Up Proteomic Platform Open
Sardinian alcohol-preferring (sP) and Sardinian alcohol-non preferring (sNP) rats have been selectively bred for opposite alcohol preference and consumption. Aiming to verify possible differences at the proteomics level between sP and sNP …
View article: Diabetes induces changes in salivary gland melatonin reactivity
Diabetes induces changes in salivary gland melatonin reactivity Open
The fine localization of melatonin and its receptors in the human salivary glands were reported in our previous works revealing, by transmission electron microscopy (TEM), that serous cells are able to store melatonin and to secrete it by …
View article: VGF Peptide Profiles in Type 2 Diabetic Patients’ Plasma and in Obese Mice
VGF Peptide Profiles in Type 2 Diabetic Patients’ Plasma and in Obese Mice Open
To address the possible involvement of VGF peptides in obesity and diabetes, we studied type 2 diabetes (T2D) and obese patients, and high-fat diet induced obese mice. Two VGF peptides (NAPP-19 and QQET-30) were identified in human plasma …
View article: Cardiovascular remodelling in female diabetic rats
Cardiovascular remodelling in female diabetic rats Open
Diabetic cardiomyopathy involves both cardiac and large vessels alterations in their biochemical and biomechanical properties. Part of these dysfunctions is due to ROS overproduction and advanced glycated end-products (AGEs) synthesis caus…
View article: Melatonin localization in serous cells of human salivary glands
Melatonin localization in serous cells of human salivary glands Open
The presence of melatonin in human saliva and its beneficial effects in the oral cavity have been extensively demonstrated, but little is known about the route by which it enters saliva. Although it is commonly believed that blood melatoni…
View article: Morphometric Study of Diabetes Related Alterations in Human Parotid Gland and Comparison with Submandibular Gland
Morphometric Study of Diabetes Related Alterations in Human Parotid Gland and Comparison with Submandibular Gland Open
Type 2 diabetes mellitus represents one of the principal diseases that afflict the world population and is often associated with malfunction of salivary glands and consequent oral diseases. We recently described significant ultrastructural…
View article: A reliable model for gamma oscillations in hippocampal tissue
A reliable model for gamma oscillations in hippocampal tissue Open
Gamma oscillations (30–100 Hz) reflect a fast brain rhythm that provides a fundamental mechanism of complex neuronal information processing in the hippocampus and in the neocortex in vivo. Gamma oscillations have been implicated in higher …
View article: Cardiac mitochondria alteration and peripheral vessel morphology in female diabetes
Cardiac mitochondria alteration and peripheral vessel morphology in female diabetes Open
One of diabetes complications is chronic cardiomyopathty and fibrotic alteration of aorta and peripheral vessels. Diabetes has been correlated to ROS superproduction (Lashin et al., 2006) and an alteration of mitochondrial chain complexes …
View article: Subcellular distribution of melatonin receptors in rat parotid salivary glands: effect of melatonin intravenous infusion
Subcellular distribution of melatonin receptors in rat parotid salivary glands: effect of melatonin intravenous infusion Open
The ultrastructural localization of melatonin receptors Mt1 and Mt2 in human salivary glands has previously been reported (Isola el al, 2013). In the acinar cells, the intragranular distribution of these receptors suggested to us that they…