Ragan Hart
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View article: Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study
Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study Open
View article: Consideration for Employer-Based and Geographic Attributes Included in Value Assessment Methods of Next-Generation Sequencing Tests
Consideration for Employer-Based and Geographic Attributes Included in Value Assessment Methods of Next-Generation Sequencing Tests Open
There is a need for formal cost-effectiveness evidence to better model the real-world payer decision context in which general economic models are currently being used, specifically regarding clinical genomics health services (for next-gene…
View article: Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests
Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests Open
In this work, we explore the results of germline cancer genetic tests in individuals whose insurance would not cover this testing. We enrolled 31 patients with a personal history of cancer whose health insurer denied coverage for a clinica…
View article: The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research
The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research Open
View article: Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study
Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study Open
View article: The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation
The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation Open
The purpose of this study was to develop a brief instrument, the Feelings About genomiC Testing Results (FACToR), to measure the psychosocial impact of returning genomic findings to patients in research and clinical practice. To create the…
View article: The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations
The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations Open
View article: Why Patients Decline Genomic Sequencing Studies: Experiences from the CSER Consortium
Why Patients Decline Genomic Sequencing Studies: Experiences from the CSER Consortium Open
Clinical and research settings are increasingly incorporating genomic sequencing (GS) technologies. Previous research has explored reasons for declining genetic testing and participation in genetic studies; however, there is a dearth of li…
View article: The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations
The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations Open
The Clinical Sequencing Evidence-Generating Research (CSER) consortium, now in its second funding cycle, is investigating the effectiveness of integrating genomic (exome or genome) sequencing into the clinical care of diverse and medically…
View article: Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting
Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting Open
View article: Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium Open
View article: Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium Open
View article: Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium Open
Evaluating the pathogenicity of a variant is challenging given the plethora of types of genetic evidence that laboratories consider. Deciding how to weigh each type of evidence is difficult, and standards have been needed. In 2015, the Ame…
View article: Illustrative Case Studies in the Return of Exome and Genome Sequencing Results
Illustrative Case Studies in the Return of Exome and Genome Sequencing Results Open
Whole genome and exome sequencing tests are increasingly being ordered in clinical practice, creating a need for research exploring the return of results from these tests. A goal of the Clinical Sequencing and Exploratory Research (CSER) c…
View article: Actionable exomic incidental findings in 6503 participants: challenges of variant classification
Actionable exomic incidental findings in 6503 participants: challenges of variant classification Open
Recommendations for laboratories to report incidental findings from genomic tests have stimulated interest in such results. In order to investigate the criteria and processes for assigning the pathogenicity of specific variants and to esti…
View article: Actionable exomic incidental findings in 6503 participants: challenges of variant classification
Actionable exomic incidental findings in 6503 participants: challenges of variant classification Open
Recommendations for laboratories to report incidental findings from genomic tests have stimulated interest in such results. In order to investigate the criteria and processes for assigning the pathogenicity of specific variants and to esti…